Импакт фактор: 1.241 5-летний Импакт фактор: 1.349 SJR: 0.356 SNIP: 0.613 CiteScore™: 1.61
ISSN Печать: 0731-8898
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Journal of Environmental Pathology, Toxicology and Oncology
Combined Effect of Radiation and Other Agents: Is There a Synergism Trap?
BfS Institute of Radiation Hygiene, Ingolstadter Landstr. 1, D-85764 Oberschleissheim, Munich, Germany
Most assessments of possible deleterious outcomes from environmental and occupational exposures concentrate on single agents and neglect the potential for combined effectsthat is, synergisms or antagonisms. Biomechanistic considerations based on multistep processes, such as carcinogenesis, indicate the potential for highly detrimental interactions if two or more consecutive rate-limiting steps are specifically effected by different agents. However, low specificity toward molecular structure or DNA sequenceand, therefore, exchangeabilityof many genotoxic agents indicate little functional specificity and, hence, little vulnerability toward synergism in most occupational and environmental exposure situations. It is also evident that a low potential exists for the combined effects of common low-exposure situations wherein nongenotoxic agents with highly nonlinear dose-effect relationships and apparent thresholds are involved. A quantitative assessment of the contribution of synergistic interactions to the total detriment from natural and man-made toxicants based on experimental data is far away.
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