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ISSN Печать: 0731-8898
ISSN Онлайн: 2162-6537
Indexed in
Antioxidant and Radiation Antagonistic Effect of Saraca indica
Краткое описание
The present study was undertaken to investigate the radiation mitigating effect of hydro-alcoholic extract of Saraca indica (SIE) against mice exposed to whole body gamma radiation. Free radical scavenging ability by SIE was demonstrated using hydroxyl, superoxide anion, ABTS•+ and DPPH radicals generated in vitro. A significant increase in the animal survival (dose reduction factor = 1.39), inhibition in the decline of hematological parameters as well as increased number of spleen colony-forming units was observed when SIE was administered prior to radiation. SIE pretreatment increased the levels of glutathione, glutathione S- trans-ferase, catalase and lowered lipid peroxidation. Our findings for the first time demonstrate the protective potential of SIE against radiation induced syndromes with an optimal dose of 400 mg/kg b.wt. The radiation mitigating effect may be attributed to the mechanisms such as free radical scavenging, elevation in antioxidant status, and reduction in lipid peroxidation.
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Das Shubhankar, Kumar Rishikesh, Rao Bola Sadashiva Satish, Radio-modifying potential ofSaraca indicaagainst ionizing radiation: an in vitro study using Chinese hamster lung fibroblast (V79) cells, Cell Biology International, 39, 9, 2015. Crossref
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Jagetia Ganesh Chandra, Shetty Prakash Chandra, Vidyasagar Mamidipudi Srinivasa, Inhibition of Radiation-Induced DNA Damage by Jamun, Syzygium cumini, in the Cultured Splenocytes of Mice Exposed to Different Doses of γ-Radiation, Integrative Cancer Therapies, 11, 2, 2012. Crossref
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Kumar Amith, Kumarchandra Reshma, Rai Rajalakshmi, Kumblekar Vasavi, Radiation mitigating activities of Psidium guajava L. against whole-body X-ray-induced damages in albino Wistar rat model, 3 Biotech, 10, 12, 2020. Crossref