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ISSN Печать: 0731-8898
ISSN Онлайн: 2162-6537
Indexed in
Hepatoprotection of Gentiana scabra Extract and Polyphenols in Liver of Carbon Tetrachloride-Intoxicated Mice
Краткое описание
In traditional Chinese medicine, the rhizomes of Gentiana scabra are used to treat hepatitis, stomatitis, and inflammatory diseases. This study aimed to examine the protective effects of G. scabra aqueous extract (GS) and polyphenols in liver of CCl4-intoxicated mice. Antioxidant activities of GS were also evaluated. Results showed that GS exhibited anti-lipid peroxidation, 2,2-diphenyl-1-picrylhydrazyl, and superoxide radical scavenging activities with IC50 values of 45.84, 183.38, and 56.25 μ/mL, respectively. High-performance liquid chromatography analysis revealed that the major polyphenolic constituents of GS were kaempferol, ellagic acid, and quercetin. Daily oral administration of 500 mg/kg GS (GS500) and 1000 mg/kg GS (GS1000) significantly prevented the elevation of glutamic pyruvic transaminase and thiobarbituric acid reactive substances levels, while enhancing the levels of antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase) and serum total antioxidant activity in mice with hepatoxicity. At 1000 mg/kg, GS was as effective as 100 mg/kg silymarin in reducing oxidative stress and preventing liver injury. Histopathological studies further confirmed the hepatoprotective activity of GS. Taken together, these results show that the antioxidant activities and polyphenolic compounds (kaempferol, ellagic acid, and quercetin) of GS may have contributed to its hepatoprotective activity in CCl4-intoxicated mice, and its mechanism of action could be mediated through the reduction of oxidative stress in liver tissue.
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García-Niño Wylly Ramsés, Zazueta Cecilia, Ellagic acid: Pharmacological activities and molecular mechanisms involved in liver protection, Pharmacological Research, 97, 2015. Crossref
-
Yoshioka Hiroki, Fukaya Shiori, Onosaka Satomi, Nonogaki Tsunemasa, Nagatsu Akito, Kampo formula “Hochu-ekki-to” suppressed carbon tetrachloride-induced hepatotoxicity in mice, Environmental Health and Preventive Medicine, 21, 6, 2016. Crossref
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Yoshioka Hiroki, Fukaya Shiori, Miura Nobuhiko, Onosaka Satomi, Nonogaki Tsunemasa, Nagatsu Akito, Suppressive Effect of Kampo Formula “Juzen-taiho-to” on Carbon Tetrachloride-Induced Hepatotoxicity in Mice, Biological & Pharmaceutical Bulletin, 39, 9, 2016. Crossref
-
Pan Yu, Zhao Yan-Li, Zhang Ji, Li Wan-Yi, Wang Yuan-Zhong, Phytochemistry and Pharmacological Activities of the GenusGentiana(Gentianaceae), Chemistry & Biodiversity, 13, 2, 2016. Crossref
-
Lee Yoo-Jung, Beak Song-Yi, Choi Inho, Sung Jung-Suk, Quercetin and its metabolites protect hepatocytes against ethanol-induced oxidative stress by activation of Nrf2 and AP-1, Food Science and Biotechnology, 27, 3, 2018. Crossref
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Yang Beodeul, Kim Sura, Kim Jung-Hoon, Lim Chiyeon, Kim Hyungwoo, Cho Suin, Gentiana scabra Bunge roots alleviates skin lesions of contact dermatitis in mice, Journal of Ethnopharmacology, 233, 2019. Crossref
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Silva Joshua, Yu Xin, Moradian Renita, Folk Carson, Spatz Maximilian H., Kim Phoebe, Bhatti Adil A., Davies Daryl L., Liang Jing, Dihydromyricetin Protects the Liver via Changes in Lipid Metabolism and Enhanced Ethanol Metabolism, Alcoholism: Clinical and Experimental Research, 44, 5, 2020. Crossref
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Huang Shih-Hung, Chen Emily hin-Fun, Wu Chin-Tung, Kuo Chao-Lin, Tsay Hsin-Sheng, Comparative analysis among three Taiwan-specific Gentiana species and Chinese medicinal plant Gentiana scabra, Botanical Studies, 54, 1, 2013. Crossref
-
Gupta Ashutosh, Singh Amit Kumar, Kumar Ramesh, Jamieson Sarah, Pandey Abhay Kumar, Bishayee Anupam, Neuroprotective Potential of Ellagic Acid: A Critical Review, Advances in Nutrition, 12, 4, 2021. Crossref
-
Mukherjee Pulok K, Efferth Thomas, Das Bhaskar, Kar Amit, Ghosh Suparna, Singha Seha, Debnath Pradip, Sharma Nanaocha, Bhardwaj Pardeep Kumar, Haldar Pallab Kanti, Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications, Phytomedicine, 98, 2022. Crossref
-
Oryan A., Naeini A. Tabatabaei, Moshiri A., Mohammadalipour A., Tabandeh M.R., Modulation of cutaneous wound healing by silymarin in rats, Journal of Wound Care, 21, 9, 2012. Crossref