Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Journal of Environmental Pathology, Toxicology and Oncology
Импакт фактор: 1.625 5-летний Импакт фактор: 1.63 SJR: 0.402 SNIP: 0.613 CiteScore™: 2.3

ISSN Печать: 0731-8898
ISSN Онлайн: 2162-6537

Выпуски:
Том 39, 2020 Том 38, 2019 Том 37, 2018 Том 36, 2017 Том 35, 2016 Том 34, 2015 Том 33, 2014 Том 32, 2013 Том 31, 2012 Том 30, 2011 Том 29, 2010 Том 28, 2009 Том 27, 2008 Том 26, 2007 Том 25, 2006 Том 24, 2005 Том 23, 2004 Том 22, 2003 Том 21, 2002 Том 20, 2001

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.2018026697
pages 231-240

Cytotoxic Effect of Spondias cytherea Fruit Extract in Murine Melanoma Model In Vivo and In Vitro

Feudjio Ndemanou Yolande
Department of Signal Transduction and Biogenic Amines, Chittaranjan National Cancer Institute, Kolkata, India; Department of Biochemistry, University of Dschang, Cameroon
Bhattacharyya Sayantan
Department of Signal Transduction and Biogenic Amines, Chittaranjan National Cancer Institute, Kolkata, India
Ghosh Paramita
Department of Signal Transduction and Biogenic Amines, Chittaranjan National Cancer Institute, Kolkata, India
Sarkar Deblina
Department of Signal Transduction and Biogenic Amines, Chittaranjan National Cancer Institute, Kolkata, India
Mouokeu Raymond Simplice
Department of Industrial Fishing, University of Douala, Cameroon
Tume B. Christopher
Department of Biochemistry, University of Dschang, Cameroon
Nabendu Murmu
Chittaranjan National Cancer Institute

Краткое описание

Cancer is a disease resulting from the deregulation of cell growth control, caused by an interaction between dietary, genetic, and environmental risk factors. Melanoma accounts for about 4% of cancers diagnosed; however they represent 75% of skin cancer–related deaths, with the incidence and death rates having increased globally over the past few decades. Spondias cytherea is a plant from the family Anacardiaceae. Its usage in the treatment of wounds, sores, and burns is reported from several countries, but the anticancer effects of the fruit have not yet been studied. We thus set out to evaluate the effects of S. cytherea fruit extract (SpE) on the epithelial to mesenchymal transition in the mouse melanoma model. B16-F10 cells cultured in varying concentrations of SpE showed a dose-dependent reduction in the ability to form colonies, which then migrate to fill up the wounded area. SpE downregulated the expression of AKT/nuclear factor kappa B/cyclooxygenase-2 (Akt/NF-κB/COX-2) responsible for cell proliferation, and reduced CD133 expression. This led to in vivo tumor shrinkage at the dose of 450 mg/kg body weight (bw). Low-level expression of vimentin on mesenchymal cells and increased E-cadherin expression on epithelial cells were observed in treated cells. The number of vasculogenic mimicry tubes that formed also decreased significantly at 450 mg/kg bw. These results suggest that S. cytherea fruit can become a useful source for chemotherapeutic drugs in the future.

Ключевые слова: CD133, COX-2, vimentin

Articles with similar content:

Anti-Inflammatory and Wound-Healing Potential of Golden Chanterelle Mushroom, Cantharellus cibarius (Agaricomycetes)
International Journal of Medicinal Mushrooms, Vol.19, 2017, issue 10
Ali Reza Khalatbary, Davood Nasiry, Mohammad Ali Ebrahimzadeh
Effect of Ukrain on Cell Survival and Apoptosis in the Androgen-Independent Prostate Cancer Cell Line PC-3
Journal of Environmental Pathology, Toxicology and Oncology, Vol.30, 2011, issue 1
Sivakamasundari Velayutham, Sharmila Govindaraj, Arunakaran Jagadeesan, Kavitha Venkatesh, Arunkumar Ramachandran, Elumalai Perumal, Senthilkumar Kalimuthu
Anti-Gastric Ulcer Activity of Polysaccharide Fraction Isolated from Mycelium Culture of Lion's Mane Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes)
International Journal of Medicinal Mushrooms, Vol.17, 2015, issue 11
Tetsuya Konishi, Yang Gao, Duoduo Xu, Mingxing Wang, Qipin Gao
Cytotoxic Activities of Funalia trogii (Berk.) Bond. Et. Singer ATCC 200800 Bioactive Extract on HeLa Cells and Fibroblast Cells
International Journal of Medicinal Mushrooms, Vol.7, 2005, issue 3
Mehmet A. Mazmanci, Ali Unyayar, Murat Demirbilek, Ozlem Cekic, Melisa Turkoglu, Hatice Atacag, Serpil Unyayar, Emrah A. Erkurt, Ayla Celik
Hypoglycemic Activity of Polysaccharide from Fruiting Bodies of the Shaggy Ink Cap Medicinal Mushroom, Coprinus comatus (Higher Basidiomycetes), on Mice Induced by Alloxan and Its Potential Mechanism
International Journal of Medicinal Mushrooms, Vol.17, 2015, issue 10
Yanfang Liu, Yan Yang, Jing-Song Zhang, Shuai Zhou, Qingjiu Tang