Импакт фактор:
1.241
5-летний Импакт фактор:
1.349
SJR:
0.356
SNIP:
0.613
CiteScore™:
1.61
ISSN Печать: 0731-8898
ISSN Онлайн: 2162-6537
Выпуски:
Том 38, 2019
Том 37, 2018
Том 36, 2017
Том 35, 2016
Том 34, 2015
Том 33, 2014
Том 32, 2013
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Том 30, 2011
Том 29, 2010
Том 28, 2009
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Том 26, 2007
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Том 20, 2001
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Journal of Environmental Pathology, Toxicology and Oncology
DOI: 10.1615/JEnvironPatholToxicolOncol.2019029549
pages 195-203
Curcumin Modulates Hepatocellular Carcinoma by Reducing UNC119 Expression
Zhenjiang Zhao
Department of Radiology, Luoyang Orthopedic Hospital of Henan Province, Zhengzhou City, Henan Province, 450000, China
Anshoo Malhotra
Innoscience Research Sdn Bhd, Subang Jaya, Selangor, Malaysia
Wu Yuan Seng
Department of Biochemistry, Faculty of Medicine and Biomedical Sciences, MAHSA University, Selangor 42610, Malaysia
Краткое описание
UNCI 19 expression has been reported to be significantly higher in hepatic cancer cells (HCC). However, the clinical significance of modulating UNC119 expression in HCC is not well understood. The study described here aimed to explore the potential of curcumin in modulation of UNC119 expression in HCC by assessment with quantitative real-time PCR, western blot, and immune-histochemical analyses in HCC cell lines and tissues. The biological functions of UNC119 in the proliferation, growth, and cycle of tumor cells were analyzed both in vitro and in vivo. UNC119 expression was upregulated in HCC cell lines and tissues as indicated by comparison with normal liver cells and tissues. Cellular function assays showed that higher levels of UNC119 not only promoted proliferation but also enhanced HCC cell migration and invasion. UNC119 promoted progression of the cell cycle and significantly promoted HCC cell growth through the Wnt/β-catenin signal pathway, and enhanced tumor migration and invasion by the TGF-β/EMT pathway. Curcumin efficiently inhibited HCC cell proliferation by blocking the Wnt/β-catenin pathway and inhabited migration and invasion by blocking the TGF-p/EMT signal pathway. Curcumin not only was beneficial for tumor remission but also contributed to the long-term survival of HCC-bearing mice. UNC119 was significantly upregulated and promoted cell growth in hepatic cancer cells and tissues by the Wnt/β-catenin signal pathway and migration by TGF-β/EMT signal pathway. Curcumin treatment inhibited cell proliferation, growth, migration, and invasion by inhibition of those pathways.
ЛИТЕРАТУРА
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