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Journal of Environmental Pathology, Toxicology and Oncology
Главный редактор: Qian Peng (open in a new tab)

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ISSN Печать: 0731-8898

ISSN Онлайн: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Modulatory influence of Phyllanthus niruri on oxidative stress, antioxidant defense and chemically induced skin tumors

Том 30, Выпуск 1, 2011, pp. 43-53
DOI: 10.1615/JEnvironPatholToxicolOncol.v30.i1.50
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Краткое описание

The present study evaluates the modulatory potential of Phyllanthus niruri on chemically induced skin carcinogenesis and its influence on oxidative stress and the antioxidant defense system. Oral administration of P. niruri extract (PNE), during peri- (Gr. III), post- (Gr. IV) or peri- and post- (Gr. V) initiational stages of 7,12-dimethylbenz(a)anthracene (DMBA) / croton oil induced papillomagenesis considerably reduced tumor burden to 4.20, 4.00 and 3.33 (positive control value 6.20); cumulative number of papillomas to 21, 16 and 10 respectively (positive control value 62); and incidence of mice bearing papillomas to 50%, 40%, and 30%, respectively (positive control value 100%) but significantly increased the average latent period to 10.14, 10.62 and 11.60 and inhibition of tumor multiplicity to 66%, 74% and 83%respectively. Enzyme analysis of skin and liver showed a significant (p ≤ 0.05, ≤ 0.01, ≤ 0.001) elevation in antioxidant parameters such as superoxide dismutase, catalase, glutathione and vitamin C in PNE treated groups (Gr. III-V) when compared with the carcinogen treated control (Gr. II). The elevated level of lipid peroxidation in the carcinogen treated positive control group was significantly (p ≤ 0.05, ≤ 0.01, ≤ 0.001) inhibited by PNE administration. These results indicate that Phyllanthus niruri extract has potentiality to reduce skin papillomas by enhancing antioxidant defense system.

ЦИТИРОВАНО В
  1. Safavi Maliheh, Shams-Ardakani Mohammadreza, Foroumadi Alireza, Medicinal plants in the treatment ofHelicobacter pyloriinfections, Pharmaceutical Biology, 53, 7, 2015. Crossref

  2. Tamborena Tatiana, Gularte Claudia Alves Ortiz, Escoto Dandara Fidelis, Gayer Mateus Cristofari, Roehrs Rafael, Folmer Vanderlei, Avila Daiana Silva, Puntel Robson L., Antioxidant Activity of some Medicinal Plant Extracts: Implications for Neuroprotection, Pharmacologia, 6, 7, 2015. Crossref

  3. Zheng Zhi-Zhong, Chen Liang-Hua, Liu Shao-Song, Deng Yuan, Zheng Guo-Hua, Gu Yue, Ming Yan-Lin, Bioguided Fraction and Isolation of the Antitumor Components fromPhyllanthus niruriL., BioMed Research International, 2016, 2016. Crossref

  4. Sowjanya Karri, Girish Chandrashekaran, Bammigatti Chanaveerappa, Prasanna Lakshmi NakkaChandrasekhar, Efficacy of Phyllanthus niruri on improving liver functions in patients with alcoholic hepatitis: A double-blind randomized controlled trial, Indian Journal of Pharmacology, 53, 6, 2021. Crossref

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