Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Journal of Environmental Pathology, Toxicology and Oncology
Импакт фактор: 1.625 5-летний Импакт фактор: 1.63 SJR: 0.402 SNIP: 0.613 CiteScore™: 2.3

ISSN Печать: 0731-8898
ISSN Онлайн: 2162-6537

Выпуски:
Том 40, 2021 Том 39, 2020 Том 38, 2019 Том 37, 2018 Том 36, 2017 Том 35, 2016 Том 34, 2015 Том 33, 2014 Том 32, 2013 Том 31, 2012 Том 30, 2011 Том 29, 2010 Том 28, 2009 Том 27, 2008 Том 26, 2007 Том 25, 2006 Том 24, 2005 Том 23, 2004 Том 22, 2003 Том 21, 2002 Том 20, 2001

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.v21.i2.40
8 pages

Redox Status-Dependent Regulation of Cyclooxygenases Mediates the Capsaicin-Induced Apoptosis in Human Neuroblastoma Cells

Yong Soo Lee
Department of Physiology, College of Medicine, Kwan-dong University, Kangnung, Korea
Eun Jin Kwon
College of Pharmacy, Yeungnam University, Kyongsan, Korea
Da Qing Jin
College of Pharmacy, Yeungnam University, Kyongsan, Korea
Seung Hee Park
College of Pharmacy, Yeungnam University, Kyongsan, Korea
Young Shin Kang
Department of Physiology, College of Medicine, Kwan-dong University, Kangnung, Korea
Keun Huh
College of Pharmacy, Yeungnam University, Kyongsan, Korea
Jung-Ae Kim
College of Pharmacy, Yeungnam University, Dae-Dong 214-1, Kyongsan 712-749, Korea

Краткое описание

Cyclooxygenases (COX) appear to be involved in the mechanism of apoptosis in various cancer cells. In this study we investigated the role of COX in the capsaicin (Cap)-induced apoptosis in SK-N-SH human neuroblastoma cells. Cap induced decreased cell viability and apoptosis in a dose-dependent manner. Cap also significantly reduced the basal generation of reactive oxygen species (ROS) and lipid peroxidation in a time-dependent fashion. Cap markedly suppressed the expression of COX-1 and COX-2. Pretreatment with NS-398, a selective COX-2 inhibitor, or indomethacin, a nonselective COX inhibitor, significantly enhanced the Cap-induced decreased cell viability and apoptosis. Exogenous application of an oxidant, Н2О2, significantly prevented the Cap-induced apoptosis and suppressed the expression of COX isoforms. These results suggest that redox status-dependent regulation of COX expression may mediate apoptosis induced by Cap in human neuroblastoma cells.


Articles with similar content:

Calcium-Sensing Receptor Arbitrates Hypoxia-Induced Proliferation of Pulmonary Artery Smooth Muscle Cells via the G Protein-PLC-IP3 Pathway
Critical Reviews™ in Eukaryotic Gene Expression, Vol.29, 2019, issue 1
Zhengying Duan, Ting Gao, Zuowu Jiao, Wei Liu, Yongxiang Tian, Keli Yang, Hui Zhang, Khalid Mehmood, Zhenyu Chang, Fangyan Yuan, Zewen Liu, Muhammad Taslim Ghori, Xiaoying Pei, Rui Guo, Muhammad Ijaz
Epidemiological and Clinical Aspects of Nonsteroidal Anti-inflammatory Drugs and Cancer Risks
Journal of Environmental Pathology, Toxicology and Oncology, Vol.21, 2002, issue 2
Edgar M. Moran
Reactive Oxygen Species Mediate Cr(VI)-induced S Phase Arrest Through p53 in Human Colon Cancer Cells
Journal of Environmental Pathology, Toxicology and Oncology, Vol.31, 2012, issue 2
Young-Ok Son, Lijuan Sun, Zhuo Zhang, Jiankang Liu, Wenqi Li, Jia Luo, Hua Yao, Xin Wang
Changes in Myocardium Metabolism in Ischemia-Reperfusion and Activation of ATP-Sensitive Potassium Channels
International Journal of Physiology and Pathophysiology, Vol.3, 2012, issue 3
Olexiy O. Moibenko, Roman A. Rovenets, Ruslan B. Strutynskyi, Anatoliy V. Kotsuruba, Anatolii P. Neshcheret
Nitric Oxide's Contribution to Selective Apoptosis Induction in Malignant Cells through Multiple Reaction Steps
Critical Reviews™ in Oncogenesis, Vol.21, 2016, issue 5-6
Georg Bauer