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Journal of Environmental Pathology, Toxicology and Oncology
Импакт фактор: 1.241 5-летний Импакт фактор: 1.349 SJR: 0.519 SNIP: 0.613 CiteScore™: 1.61

ISSN Печать: 0731-8898
ISSN Онлайн: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.2018025306
pages 81-91

Clinicopathological Characteristics and Prognoses of Elderly Gastric Cancer Patients after R0 Resection: A Multicenter Study in China

Xinfu Ma
Department of Medical Oncology, Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, 810000, China
Dengfeng Ren
Department of Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, China
Jie Kan
Department of Medical Oncology, Qinghai Provincial People's Hospital, Xining, 810000, China
Fangchao Zheng
Department of Medical Oncology, Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, 810000, China; Department of Medical Oncology, Shouguang Hospital of Traditional Chinese Medicine, Weifang, 261000, China
Shuisheng Zhang
Department of Pancreatic and Gastric Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China
Yu Zhang
Department of Medical Oncology, Qinghai Red Cross Hospital, Xining, 810000, China
Yuying Li
Department of Medical Oncology, Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, 810000, China
Zhibo Liu
Department of Medical Oncology, Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, 810000, China
Linhan Ye
Department of Medical Oncology, Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, 810000, China; Department of Pain Treatment, Anhui Province Hospital, Hefei, 230000, China
Guoshuang Shen
Department of Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, China
Ziyi Wang
Department of Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, China
Fuxing Zhao
Department of Medical Oncology, Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, 810000, China
Raees Ahmad
Department of Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, China
Jiuda Zhao
Department of Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, China

Краткое описание

The number of elderly gastric cancer (GC) patients has been rapidly increasing worldwide, but inadequate understanding regarding elderly GC patients has led to the paucity of appropriate treatment decisions. Our study evaluates clinicopathological characteristics and prognoses of elderly GC patients after R0 resection. Overall, 1877 consecutive GC patients who underwent R0 gastrectomy at four centers were enrolled. We divided patients into three groups according to age: young, middle, and elderly. We then analyzed clinicopathological characteristics and prognoses. Compared to the middle-aged group, the elderly group had a higher male-to-female ratio and number of patients with cardiac GC, trend of more advanced pathological stage, lower ratio of poor to moderate tumor grade, and fewer patients who received adjuvant chemotherapy or chemoradiotherapy. Moreover, 5 yr disease-free survival and overall survival rates of elderly patients were significantly less than those of middle-aged patients. A Cox analysis of middle-aged and elderly patients revealed that age and adjuvant chemotherapy were independent prognostic factors. Adjuvant chemotherapy improved long-term survival of elderly patients with stage III cancer. Elderly GC patients who underwent R0 resection had unique characteristics and poor long-term survival. We found that subjects should be stratified into the three aforementioned age groups when analyzing survival rates of GC patients. In addition, reasonable adjuvant treatment is recommended for elderly patients.

Ключевые слова: gastric cancer, elderly patients, prognosis, gastrectomy

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