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Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Journal of Environmental Pathology, Toxicology and Oncology
Импакт фактор: 1.625 5-летний Импакт фактор: 1.63 SJR: 0.402 SNIP: 0.613 CiteScore™: 2.3

ISSN Печать: 0731-8898
ISSN Онлайн: 2162-6537

Выпуски:
Том 40, 2021 Том 39, 2020 Том 38, 2019 Том 37, 2018 Том 36, 2017 Том 35, 2016 Том 34, 2015 Том 33, 2014 Том 32, 2013 Том 31, 2012 Том 30, 2011 Том 29, 2010 Том 28, 2009 Том 27, 2008 Том 26, 2007 Том 25, 2006 Том 24, 2005 Том 23, 2004 Том 22, 2003 Том 21, 2002 Том 20, 2001

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.v26.i1.20
pages 9-20

Abrogation of Thioacetamide-Induced Biochemical Events of Hepatic Tumor Promotion Stage by Tannic Acid in Wistar Rats

Anuradha Sehrawat
Section of Chemoprevention and Nutrition Toxicology, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard (Hamdard University), New Delhi 110 062, India
Sarwat Sultana
Section of Molecular Carcinogenesis and Chemoprevention, Department of Medical Elementology and Toxicology, School of Chemical and Life Sciences amia Hamdard, New Delhi, India

Краткое описание

Tannic acid is present in almost every edible plant and is generally used as a safe food additive. In this study we investigated the antioxidative and antihyperproliferative potential of tannic acid against thioacetoamide (TAA), a potent hepatotoxic-substance-induced oxidative stress and hyperproliferation biomarker. We have shown here that the activities of hepatic antioxidant enzymes, phase II metabolizing enzymes, and the glutathione content were decreased while hepatic ornithine decarboxylase activity and DNA synthesis were induced in TAA-treated animals. Tannic acid administration at two different doses prior to the TAA injection partially recovered the depleted level of glutathione, inhibited activities of antioxidant and phase II metabolizing enzymes, and resulted in significant inhibition of oxidative stress in a dose-dependent manner. Tannic acid administration before TAA treatment also resulted in a significant decrease in ODC activity and [3H]-thymidine incorporation in rat liver, which are classical markers of inflammation and tumor promotion. Our data clearly demonstrate that tannic acid possesses antioxidant and antiproliferating activities because it inhibits early biomarkers of TAA-induced tumor promotion in an in vivo animal model.


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