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Journal of Environmental Pathology, Toxicology and Oncology
Главный редактор: Qian Peng (open in a new tab)

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ISSN Печать: 0731-8898

ISSN Онлайн: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Anticancer Property of Iron Oxide Nanoparticle-Drug Complexes: An In Vitro Study

Том 34, Выпуск 3, 2015, pp. 183-189
DOI: 10.1615/JEnvironPatholToxicolOncol.2015013482
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Краткое описание

Tumor-specific targeting of chemotherapeutic drugs can increase the therapeutic efficacy of most anticancer drugs. On surface-modified iron oxide nanoparticles (NPs), we complexed a hypoxic cell-targeting agent, sanazole (SAN), and a cytotoxic isoquinoline alkaloid, berberine (BBN). The major objective of this study was to elucidate the molecular mechanism of cytotoxicity in murine tumor cells (DLA) induced by NP−BBN-SAN complexes. The cytotoxicity of these complexes was determined using the dye exclusion method. The induction of apoptosis and cellular DNA damage in these cells was analyzed using dual staining and comet assay, respectively. The expression of genes in the treated cells elucidated the molecular mechanism underlying cytotoxicity. Cells treated with NP−BBN-SAN complexes showed significant increases in cytotoxicity and apoptosis, as well as extensive damage to cellular DNA compared to control cells. The cells treated with NP−BBN-SAN complexes showed greater DNA damage compared with other treatments. The increase in the expression of a pro-apoptotic gene suggested that apoptosis was the mechanism underlying cytotoxicity induced by NP−BBN-SAN complexes. Complexing with SAN increased the cytotoxic potential of NP−BBN complexes. Further in vivo studies are needed to evaluate the potential application of this method in controlling tumors.

ЦИТИРОВАНО В
  1. Sreeja S., Krishnan Nair Cherupally Krishnan, Chemo-directed specific targeting of nanoparticle-doxorubicin complexes to tumor in animal model, Journal of Drug Delivery Science and Technology, 31, 2016. Crossref

  2. Sreeja S., Krishnan Nair C.K., Tumor control by hypoxia-specific chemotargeting of iron-oxide nanoparticle – Berberine complexes in a mouse model, Life Sciences, 195, 2018. Crossref

  3. Ahmadi Shahram, Fazilati Mohammad, Nazem Habibollah, Mousavi Seyyed Mojtaba, Ramoji Kosuru, Green Synthesis of Magnetic Nanoparticles Using Satureja hortensis Essential Oil toward Superior Antibacterial/Fungal and Anticancer Performance, BioMed Research International, 2021, 2021. Crossref

  4. Sullivan Mark V, Stockburn William J, Hawes Philippa C, Mercer Tim, Reddy Subrayal M, Green synthesis as a simple and rapid route to protein modified magnetic nanoparticles for use in the development of a fluorometric molecularly imprinted polymer-based assay for detection of myoglobin, Nanotechnology, 32, 9, 2021. Crossref

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