Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Journal of Environmental Pathology, Toxicology and Oncology
Импакт фактор: 1.241 5-летний Импакт фактор: 1.349 SJR: 0.519 SNIP: 0.613 CiteScore™: 1.61

ISSN Печать: 0731-8898
ISSN Онлайн: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.2015013663
pages 201-212

Cytoskeletal Focal Adhesion Proteins Fascin-1 and Paxillin Are Predictors of Malignant Progression and Poor Prognosis in Human Breast Cancer

Ola M. Omran
Departments of Pathology, Faculty of Medicine, Assiut and Qassim Universities, Egypt and Kingdom of Saudi Arabia
Muneera Al Sheeha
Department of Obstetrics and Gynecology, College of Medicine, Qassim University, Qassim, Saudi Arabia

Краткое описание

Breast cancer is a major health problem in both developing and developed countries. The incremental motility of malignant cells is a critical step in their migration, invasion, and metastasis and is regulated by the reorganization of the actin cytoskeleton and regulation of focal adhesion. Fascin-1 and paxillin are essential components of these cellular structures. In cancer, the expression level of fascin-1 and paxillin can vary depending on cell type. However, its precise role in breast cancer of Saudi women has not been evaluated in any published study. We investigated fascin-1 and paxillin expression in breast carcinoma, and we have related these results to the established prognostic factors. We studied 100 breast carcinoma specimens. Immunohistochemical analyses for fascin-1 and paxillin were conducted on paraffin sections of breast tissues using the avidin-biotin peroxidase method. Fascin-1 and paxillin were expressed in 58% and 43% of infiltrating duct carcinoma (IDC) cases. There was a statistically significant correlation between fascin-1 and paxillin expression with each of the following: tumor grade, clinical stage, lymph-node metastasis grade, and HER2 expression. Furthermore, there was a significant correlation between fascin-1 expression with paxillin immunostaining but no such association with PR or ER status. Increased fascin-1 and paxillin expression in IDC cells and their correlation with poor prognostic factors support their strong correlation with tumor progression, invasion, and metastasis in human breast cancer, indicating that these markers can be used as a target for the development of novel therapies.

Ключевые слова: immunohistochemistry, breast carcinoma, fascin-1, paxillin

Articles with similar content:

The Prognostic Value of Breast Cancer Resistance Protein (BCRB/ABCG2) Expression in Breast Carcinomas
Journal of Environmental Pathology, Toxicology and Oncology, Vol.31, 2012, issue 4
Ola M. Omran
CD10 and E-Cad Expression in Urinary Bladder Urothelial and Squamous Cell Carcinoma
Journal of Environmental Pathology, Toxicology and Oncology, Vol.31, 2012, issue 3
Ola M. Omran
Role of the Progesterone Receptor (PR) and the PR Isoforms in Breast Cancer
Critical Reviews™ in Oncogenesis, Vol.13, 2007, issue 4
Orla Mc Cormack, Michael J. Kerin, Amanda McCann, Michele Harrison
Survey of Raf Kinase Inhibitor Protein (RKIP) in Multiple Cancer Types
Critical Reviews™ in Oncogenesis, Vol.19, 2014, issue 6
Kelly Lamiman, Jian Zhang, Jill M. Keller, Atsushi Mizokami, Evan T. Keller
Gastric Adenocarcinoma Biomarker Expression Profiles and their Prognostic Value
Journal of Environmental Pathology, Toxicology and Oncology, Vol.35, 2016, issue 3
Ibrahim Akalin, Duygu Kösemetin, Dilek Ece, Abdullah Aydin, Hasan Abuoglu, Esra Akdeniz Duran, Serkan Senol, Dincer Aydin, Burcak Erkol