Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Journal of Environmental Pathology, Toxicology and Oncology
Импакт фактор: 1.241 5-летний Импакт фактор: 1.349 SJR: 0.356 SNIP: 0.613 CiteScore™: 1.61

ISSN Печать: 0731-8898
ISSN Онлайн: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvPathToxOncol.v22.i2.60
10 pages

Dietary Cured Meat and the Risk of Adult Glioma: A Meta-Analysis of Nine Observational Studies

Michael Huncharek
Division of Radiation Oncology, John Cochrane VA Medical Center, St. Louis, Department of Clinical Oncology, Marsh. eld Clinic Cancer Center, Marshfield, Wisconsin and Meta-Analysis Research Group, Stevens Point, Wisconsin
Bruce Kupelnick
Meta-Analysis Research Group, Stevens Point, Wisconsin
Lamar Wheeler
Meta-Analysis Research Group, Stevens Point, Wisconsin

Краткое описание

Objective: N-nitroso compounds (NOCs) are recognized neural carcinogens in animal models and are suspected human carcinogens. A meta-analysis was performed examining the possible association of dietary N-nitroso intake from cured meats and the risk of gliomas in adults. Methods: A prospective protocol was developed outlining the intent, methods, and statistical analysis of the meta-analysis. Data from nine epidemiological studies were pooled using a general variance-based meta-analytic method employing confidence intervals as described by Greenland. The outcome of interest was a summary relative risk (SRR) reflecting the risk of brain tumor (glioma) development associated with high dietary intake of cured meats (as defined by individual study investigators). Sensitivity analyses were performed when necessary to explain any observed statistical heterogeneity. Results: Nine observational studies met protocol- specified inclusion criteria. Analysis for heterogeneity demonstrated a lack of statistical heterogeneity (p = 0.58). Pooling the data on dietary cured meat intake of all types yielded an RR of 1.48 (1.20–1.83), suggesting a 48% increased risk of glioma development among adults ingesting high levels of cured meat. Analyzing brain tumor risk by meat type yielded an RR of 0.90 (0.63–1.25) for hotdogs (a nonstatistically significant result), 1.31 (1.00–1.71) for bacon, and 1.64 (1.27–2.14) for ham. Sensitivity analyses showed that the failure of most studies to adjust for total energy intake might lead to a spurious positive association between cured meat intake and brain tumor risk. Insufficient data were available for analyzing dose– response relationships, although a few individual studies showed evidence of increasing risk with increasing cured meat intake. Conclusion: The available data do not provide clear sup port for the suspected causal association between ingestion of NOCs from cured meat in adults and subsequent brain tumor risk. Uncontrolled confounding may account for the previously noted positive association seen in some epidemiological studies.


Articles with similar content:

Maternal Intake of N-nitroso Compounds from Cured Meat and the Risk of Pediatric Brain Tumors: A Review
Journal of Environmental Pathology, Toxicology and Oncology, Vol.29, 2010, issue 3
Michael Huncharek
Prognostic Value of Ki-67/MIB-1 Expression in Meningioma Patients: A Meta-Analysis
Critical Reviews™ in Eukaryotic Gene Expression, Vol.29, 2019, issue 2
Ruofei Liang, Yanhui Liu, Junhong Li, Yufan Xiang, Chen Song
XRCC1 Arg194Trp and Arg280His Polymorphisms in Bladder Cancer Susceptibility: A Meta-Analysis
Critical Reviews™ in Eukaryotic Gene Expression, Vol.23, 2013, issue 4
Guangjun Jiao, Qinghua Yin, Lian Li, Chuan Liu, Yajie Wang, Mei Wang
TCF7L2 rs12255372 (G > T) Polymorphism Contributes to Breast Carcinogenesis: Evidence from a Meta-Analysis
Critical Reviews™ in Eukaryotic Gene Expression, Vol.23, 2013, issue 4
Qun Zhang, Zexing Wang, Weiwei Nie, Fengxia Chen, Bin Yang, Yanru Wang, Xiaoxiang Guan
ABCB1 Polymorphisms and Childhood Acute Lymphoblastic Leukemia Risk: A Meta-Analysis
Critical Reviews™ in Eukaryotic Gene Expression, Vol.27, 2017, issue 2
Lu Zhan, Junlan Lian, Zhengyang Shao, Sunyao Wang, Haili Jin, Jiajun Ding