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Journal of Environmental Pathology, Toxicology and Oncology
Главный редактор: Qian Peng (open in a new tab)

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ISSN Печать: 0731-8898

ISSN Онлайн: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Bacillus thuringiensis Parasporal Proteins Induce Cell-Cycle Arrest and Caspase-Dependant Apoptotic Cell Death in Leukemic Cells

Том 31, Выпуск 1, 2012, pp. 75-86
DOI: 10.1615/JEnvironPatholToxicolOncol.v31.i1.80
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Краткое описание

Bacillus thuringiensis (Bt) parasporal proteins with selective anticancer activity have recently garnered interest. This study determines the efficacy and mode of cell death of Bt 18 parasporal proteins against 3 leukemic cell lines (CEM-SS, CCRF-SB and CCRF-HSB-2).Cell-based biochemical analysis aimed to determine cell viability and the percentage of apoptotic cell death in treated cell lines; ultrastructural analysis to study apoptotic changes and Western blot to identify the parasporal proteins' binding site were performed. Bt 18 parasporal proteins moderately decreased viability of leukemic cells but not that of normal human T lymphocytes. Further purification of the proteins showed changes in inhibition selectivity. Phosphatidylserine externalization, active caspase-3, cell cycle, and ultrastructural analysis confirmed apoptotic activity and S-phase cell-cycle arrest. Western blot analysis demonstrated glyceraldehyde 3-phosphate dehydrogenase as a binding protein. We suggest that Bt 18 parasporal proteins inhibit leukemic cell viability by cell-cycle arrest and apoptosis and that glyceraldehyde 3-phosphate dehydrogenase binding initiates apoptosis.

ЦИТИРОВАНО В
  1. Franco Molina M A, Mendoza Gamboa E, Roman Calderon M E, Zapata Benavides P, Rivera Morales L G, Zapata Monsivais L, Coronado ndash Cerda E E, Sierra Rivera C A, Tamez Guerra R, Rodr iacute guez Padilla C, In vitro antitumoral activity of soluble protein extracts of Bacillus thuringiensis, African Journal of Microbiology Research, 10, 10, 2016. Crossref

  2. Gurnev Philip, Nestorovich Ekaterina, Channel-Forming Bacterial Toxins in Biosensing and Macromolecule Delivery, Toxins, 6, 8, 2014. Crossref

  3. Chi Xiaoyuan, Su Peng, Bi Dan, Tai Zhao, Li Yingying, Pang Yue, Li Qingwei, Lamprey immune protein-1 (LIP-1) from Lampetra japonica induces cell cycle arrest and cell death in HeLa cells, Fish & Shellfish Immunology, 75, 2018. Crossref

  4. Beena V., Ramnath V., Sreekumar K. P., Karthiayini K., Philomina P. T., Girija D., Crystal Protein of a Novel Bacillus thuringiensis Strain Inducing Cell Cycle Arrest and Apoptotic Cell Death in Human Leukemic Cells, Scientific Reports, 9, 1, 2019. Crossref

  5. Chu Wan-Loy, Tan Eng-Lai, Ambu Stephen, Leong Chee-Onn, Nadarajah Vishna Devi, Lim Patricia Kim-Chooi, Wong Shew-Fung, Khor Geok-Lin, Menke James Michael, Mak Joon-Wah, Institute for Research, Development and Innovation (IRDI) of the International Medical University (IMU), Malaysia, in The Malaysia-Japan Model on Technology Partnership, 2015. Crossref

  6. Hernandez-Salas Yajaira, Hernandez-Teran Fernando, Balaguramy Nagamani, De La Fuente-Salcido Norma, Alternativa biotecnológica contra el cáncer: Parasporinas de Bacillus thuringiensis, Revista de Ingeniería Biomédica y Biotecnología, 2019. Crossref

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