Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Journal of Environmental Pathology, Toxicology and Oncology
Импакт фактор: 1.241 5-летний Импакт фактор: 1.349 SJR: 0.356 SNIP: 0.613 CiteScore™: 1.61

ISSN Печать: 0731-8898
ISSN Онлайн: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvPathToxOncol.v22.i4.20
6 pages

Clastogenic Effects of Streptozotocin on Human Colon Cancer Cell Lines with Gene Amplification

Martha Susana Bianchi
Laboratorio de Citogenética y Mutagénesis, Instituto Multidisciplinario de Biologia Celular (IMBICE, CCT-La Plata-CONICET-CICPBA); Miembro de la Carrera del Investigador Cientifico del CONICET, Argentina
Alejandro Daniel Bolzan
Laboratorio de Citogenética y Mutagénesis, Instituto Multidisciplinario de Biologia Celular (IMBICE, CCT-La Plata-CONICET-CICPBA); Miembro de la Carrera del Investigador Cientifico del CONICET, Argentina

Краткое описание

We investigated the clastogenic effects of the methylating agent streptozotocin (STZ) on two human colon cancer cell lines. COLO320DM and COLO320HSR are cell lines derived from a human neuroendocrine colon carcinoma. STZ produced a dose-dependent increase in the frequency of chromosomal aberrations in both cell lines (p < 0.05) and induced fragmentation and/or pulverization of COLO320DM and COLO320HSR chromosomes. This effect was dose and time dependent. Severe chromosome damage was also found in cells that had progressed beyond the first metaphase, and a higher percentage of metaphases showing pulverized chromosomes were found in cells after the second than after the first division. This seems to indicate that STZ has a persistent and delayed clastogenic effect on COLO320DM and COLO320HSR cells. In addition, STZ produced a marked depression of the mitotic index in both cell lines. These results demonstrate that human colon cancer cell lines COLO320DM and COLO320HSR are highly sensitive to STZ, and suggest that this antibiotic has a good potential as a chemotherapeutic agent for colon cancer.


Articles with similar content:

Heat Shock Protein 27 Protects against Aminolevulinic Acid-Mediated Photodynamic Therapy-Induced Apoptosis and Necrosis in Human Breast Cancer Cells
Journal of Environmental Pathology, Toxicology and Oncology, Vol.26, 2007, issue 3
Sarah A. Ziegler, Stephen W. Carper, Steen J. Madsen, Cherisse Loucks
Characterization of Apoptosis Induced by Photodynamic Treatment with Hypericin in A431 Human Epidermoid Carcinoma Cells
Journal of Environmental Pathology, Toxicology and Oncology, Vol.25, 2006, issue 1-2
Barbara Krammer, Franz Josef Obermair, Christian Benno Oberdanner, Tobias Kiesslich, Juergen Berlanda, Kristjan Plaetzer
Bacillus thuringiensis Parasporal Proteins Induce Cell-Cycle Arrest and Caspase-Dependant Apoptotic Cell Death in Leukemic Cells
Journal of Environmental Pathology, Toxicology and Oncology, Vol.31, 2012, issue 1
Vishna Devi Nadarajah, Rebecca Shin-Yee Wong, Tengku Azmi Tengku Ibrahim, KoK-Keong Chan, Shar Mariam Mohamed, Maha Abdullah
Protective Effect of Solanum muricatum on Tumor Metastasis by Regulating Inflammatory Mediators and Nuclear Factor-Kappa B Subunits
Journal of Environmental Pathology, Toxicology and Oncology, Vol.34, 2015, issue 3
Chandrasekaran Guruvayoorappan, Kittappa Shathish, Kunnathur Murugesan Sakthivel
Mechanisms of Nephrotoxicity of Novel Anticancer Compound Maleimide Derivative MI-1
International Journal of Physiology and Pathophysiology, Vol.5, 2014, issue 2
Oleg Andrukhov, Olena Andrukhova, Volodymyr K. Rybalchenko, Iryna V. Kharchuk