Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Journal of Environmental Pathology, Toxicology and Oncology
Импакт фактор: 1.241 5-летний Импакт фактор: 1.349 SJR: 0.519 SNIP: 0.613 CiteScore™: 1.61

ISSN Печать: 0731-8898
ISSN Онлайн: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvPathToxOncol.v23.i2.80
8 pages

Relevance of Radioprotectors in Radiotherapy: Studies with Tocopherol Monoglucoside

Cherupally Krishnan Krishnan Nair
Mar Athanasious College for Advanced Studies, Tiruvalla, Tiruvalla, Kerala, India; St.Gregorios Dental College & Research Centre, Kothamangalam, Kerala, India
Veena Salvi
Radiation Biology and Health Sciences Division, Bhabha Atomic Research Center, Mumbai, India
Tsutomu V. Kagiya
Health Research Foundation, Kinki Invention Center, Kyoto, Japan
Rema Rajagopalan
Radiation Biology Division, Bhabha Atomic Research Centre, Bombay, India

Краткое описание

Radioprotective compounds are of importance in clinical radiation therapy, because normal tissues should be protected against radiation injury while using higher doses of radiation to obtain better cancer control. We investigated the radioprotection of cellular DNA in cancer and in various cells and tissues, in a murine system following exposure to γ-radiation and tocopherol monoglucoside (TMG) administration. We used single-cell gel electrophoresis (comet assay) and studied the progression of murine fibrosarcoma following radiation exposure and administration of TMG. The administration of TMG to tumor-bearing mice protected the cellular DNA against radiation-induced strand breaks as shown by the decrease in comet tail length, tail moment, and percentage of DNA in the tails of the cells of normal tissues. The same parameters were not altered in the cells of fibrosarcoma. Our results showed that the administration of TMG immediately after exposure to γ-radiation can protect normal tissues against radiation damages in tumor-bearing mice. Local γ-radiation exposure (5 Gy) of the tumor retarded the tumor growth. Administration of TMG did not protect cancer cells from radiation damage because the growth curves of cancer cells treated with radiation alone and those treated with TMG after irradiation were not significantly different.


Articles with similar content:

Jaggery Protects Hepatorenal Injury Induced by Acute Exposure to Carbon Tetrachloride in Wistar rats
Journal of Environmental Pathology, Toxicology and Oncology, Vol.32, 2013, issue 1
Vinay Sharma, Monika Sharma, Chandra Kant Sharma
Chemopreventive Efficacy of (+)-Catechin-Rich Aqueous Extract of Acacia catechu Willd. Heartwood against 7,12-Dimethylbenz[a]Anthracene-Induced Hepatocarcinoma in Balb/c Mice
Journal of Environmental Pathology, Toxicology and Oncology, Vol.31, 2012, issue 4
Manu Sharma, Jitender Monga, Chetan Singh Chauhan
Protective Role of Naringenin Against Doxorubicin-Induced Cardiotoxicity in a Rat Model: Histopathology and mRNA Expression Profile Studies
Journal of Environmental Pathology, Toxicology and Oncology, Vol.33, 2014, issue 4
Kumaresan Ganesan, Murugesan Ramachandran, Swathika Subburaman
Antitumor Effects of Palladium−α−Lipoic Acid Complex Formulation as an Adjunct in Radiotherapy
Journal of Environmental Pathology, Toxicology and Oncology, Vol.35, 2016, issue 4
Thekkuttuparambil Ananthanarayanan Ajith, Kainoor K. Janardhanan, Ravindran Kalathil Veena, Francis Antonawich
Radioprotection by Copper and Zinc Complexes of 5-Aminosalicylic Acid: A Preliminary Study
Journal of Environmental Pathology, Toxicology and Oncology, Vol.27, 2008, issue 2
M. K. Unnikrishnan, S. K. Mantena, K. Chandrasekharan