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Journal of Environmental Pathology, Toxicology and Oncology
Главный редактор: Qian Peng (open in a new tab)

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ISSN Печать: 0731-8898

ISSN Онлайн: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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On the Safety of Reduced Nicotinamide Adenine Dinucleotide (NADH)

Том 23, Выпуск 3, 2004, 16 pages
DOI: 10.1615/JEnvPathToxOncol.v23.i3.20
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Краткое описание

The objective of the study was to determine both the toxicity of the stabilized orally absorbable form of nicotinamide adenine dinucleotide (NADH) (ENADA®) and the maximum tolerated intravenous dose (MTD) of βNADH (the reduced form of NADH) in beagle dogs. The administration of the stabilized orally absorbable form of NADH to beagle dogs at dose levels of 20, 100, and 150 mg/kg for 14 days elicited no signs of a toxicological effect. A transitory change in stool formation was observed with the intermediate and high dose in males. There were also apparent increases in adrenal, heart, kidney, liver, brain, and thyroid weights, particularly in males, but none of these changes were considered to be toxicologically significant. In addition, four dogs (two of each sex) received intravenous infusions of 100 mg NADH/kg/day for 4 days, followed by 200 mg NADH/kg/day for 3 days, followed by 500 mg NADH/kg/day for 4 days, and 1000 mg NADH/kg/day on the final day. At the end of the MTD phase, the control animals that had received saline solution in the MTD phase were used to evaluate the potential toxicity of the established MTD. These animals received 500 mg NADH/kg/day for 14 days (fixed dose phase). There were no deaths. At dose levels between 100 and 1000 mg/kg/day, effects on the cardiovascular system and also some evidence of an effect on the central nervous system and on the adrenals were observed. At doses of 500 mg/kg/day and above, food consumption and body weight were reduced. On the basis of the observed changes, the maximum intravenous dose of NADH tolerated by beagle dogs was considered to be 500 mg/kg/day. There were no gross histological findings indicative of toxicity in the organs of tissues examined. Based on these findings, the stabilized orally absorbable form of NADH (ENADA) can be regarded as safe.

ЦИТИРОВАНО В
  1. KIMURA Naoko, FUKUWATARI Tsutomu, SASAKI Ryuzo, SHIBATA Katsumi, Comparison of Metabolic Fates of Nicotinamide, NAD<sup>+</sup> and NADH Administered Orally and Intraperitoneally; Characterization of Oral NADH, Journal of Nutritional Science and Vitaminology, 52, 2, 2006. Crossref

  2. Mero Antti, Raitanen Riikka, Birkmayer Joerg, Komi Paavo, Effects of nicotinamide adenine dinucleotide hydride on physical and mental performance, Journal of Sports Sciences, 26, 3, 2008. Crossref

  3. Sanches Eliane S. A. M., Tsuzuki Felipe, Joinhas Fábio A., Martins Caio C. N., Fernandes Glaura S. A., Salles Maria J. S., Bupropion promotes alterations in the spermatogenesis of mice and congenital malformations in the offspring, Reproduction, Fertility and Development, 30, 12, 2018. Crossref

  4. Ostojic Sergej M., Novel nutraceuticals to tackle brain and muscle bioenergetics, in Clinical Bioenergetics, 2021. Crossref

  5. Yamada Magohei, Matsuhira Takashi, Yamamoto Keizo, Sakai Hiromi, Antioxidative Pseudoenzymatic Mechanism of NAD(P)H Coexisting with Oxyhemoglobin for Suppressed Methemoglobin Formation, Biochemistry, 58, 10, 2019. Crossref

  6. Cui Yin Hua, Shi Qing Shan, Zhang Dan Dan, Wang Ling Ling, Feng Jin, Chen Yi Wen, Xie Xiao Bao, Detoxification of ionic liquids using glutathione, cysteine, and NADH: Toxicity evaluation by Tetrahymena pyriformis, Environmental Pollution, 276, 2021. Crossref

  7. Arenas-Jal Marta, Suñé-Negre J.M., García-Montoya Encarna, Therapeutic potential of nicotinamide adenine dinucleotide (NAD), European Journal of Pharmacology, 879, 2020. Crossref

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