Доступ предоставлен для: Guest
Journal of Environmental Pathology, Toxicology and Oncology
Главный редактор: Qian Peng (open in a new tab)

Выходит 4 номеров в год

ISSN Печать: 0731-8898

ISSN Онлайн: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Protective Effect of Alstonia scholaris Against Radiation-Induced Clastogenic and Biochemical Alterations in Mice

Том 29, Выпуск 2, 2010, pp. 101-111
DOI: 10.1615/JEnvironPatholToxicolOncol.v29.i2.40
Get accessGet access

Краткое описание

We studied the radioprotective effect of Alstonia scholaris bark extract (ASE) on cytogenetic alterations in the form of chromosomal aberrations and micronuclei induction in bone marrow. For this purpose, one group of male Swiss albino mice was exposed to 2.5 Gy gamma radiation to serve as the irradiated control, while the other group received ASE (100 mg/kg bwt/d) orally for 5 consecutive days 30 min before irradiation to serve as the experimental group. Results indicated that dicentrics and chromosomal exchanges were increased at 12 h post-exposure in both groups, followed by a gradual decline and then disappearance by d 15 and 7, respectively. However, the occurrence of chromatid breaks and acentric fragments was also maximum at 12 h, and later decreased without attaining the normal value, even up to the last necropsy interval. The percentage of such aberrations was significantly less in the ASE-pretreated irradiated animals. The incidence of chromosome breaks and centric rings kept increasing up to d 1, but then declined gradually and reached zero beginning at d 7; they were significantly lower in the ASE-treated irradiated group at the early intervals. A significant decrease in glutathione (GSH) and an increase in lipid peroxidation were observed after radiation exposure in untreated controls, whereas ASE-pretreated irradiated animals exhibited a significant increase in GSH and a decrease in lipid peroxidation; however, the values remained below normal. The results from the present study suggest that ASE pretreatment provides protection against radiation-induced chromosomal damage and micronuclei induction in the bone marrow of mice.

ЦИТИРОВАНО В
  1. Mistry Dhruti, Pithawala Meonis, Protective effect of Alstonia scholaris Linn. R. Br. against Bleomycin induced chromosomal damage in cultured human lymphocytes, in vitro, Drug and Chemical Toxicology, 41, 2, 2018. Crossref

  2. Sahin Kazim, Ali Shakir, Sahin Nurhan, Orhan Cemal, Kucuk Omer, Lycopene: Multitargeted Applications in Cancer Therapy, in Natural Products and Cancer Drug Discovery, 2017. Crossref

  3. Bala Shashi, Chugh Neha Arora, Bansal Subhash Chand, Garg Mohan Lal, Koul Ashwani, Radiomodulatory effects of Aloe vera on hepatic and renal tissues of X-ray irradiated mice, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 811, 2018. Crossref

  4. Raj Seema, Manchanda Romila, Bhandari Meena, Alam Md. Sabir, Review on Natural Bioactive Products as Radioprotective Therapeutics: Present and Past Perspective, Current Pharmaceutical Biotechnology, 23, 14, 2022. Crossref

563 Просмотры статей 20 Загрузка статей Метрики
563 ПРОСМОТРЫ 20 ЗАГРУЗКИ 4 Crossref ЦИТАТЫ Google
Scholar
ЦИТАТЫ

Статьи с похожим содержанием:

Influence of Rosemarinus officinalis Extract on Radiation-Induced Intestinal Injury in Mice Journal of Environmental Pathology, Toxicology and Oncology, Vol.29, 2010, issue 3
Pradeep Kumar Goyal, Archana Jindal, Annapurna Agrawal
Radioprotective Potential of Rosemarinus officinalis against Lethal Effects of Gamma Radiation : A Preliminary Study Journal of Environmental Pathology, Toxicology and Oncology, Vol.25, 2006, issue 4
Dhanraj Soyal, Pradeep Kumar Goyal, Archana Jindal, Garima Sancheti
Effects of Aegle marmelos (L.) Correa on the Peripheral Blood and Small Intestine of Mice Exposed to Gamma Radiation Journal of Environmental Pathology, Toxicology and Oncology, Vol.25, 2006, issue 4
Ponemone Venkatesh, Parampally Archana, Ganesh Chandra Jagetia, Manjeshwar Shrinath Baliga, Bhandarkar R. Krishnanand
Radioprotective Effects of Aloe Vera Leaf Extract on Swiss Albino Mice against Whole-Body Gamma Irradiation Journal of Environmental Pathology, Toxicology and Oncology, Vol.28, 2009, issue 1
Pradeep Kumar Goyal, Prashasnika Gehlot
Protection of Ionizing Radiation-Induced Cytogenetic Damage by Hydroalcoholic Extract of Cynodon Dactylon in Chinese Hamster Lung Fibroblast Cells and Human Peripheral Blood Lymphocytes Journal of Environmental Pathology, Toxicology and Oncology, Vol.27, 2008, issue 2
Dinesh Upadhya, Bola Sadashiva Satish Rao, Satish Kumar Adiga
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции Цены и условия подписки Begell House Контакты Language English 中文 Русский Português German French Spain