Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Forum on Immunopathological Diseases and Therapeutics
SJR: 0.309 SNIP: 0.041 CiteScore™: 0.18

ISSN Печать: 2151-8017
ISSN Онлайн: 2151-8025

Archives: Volume 1, 2010 to Volume 7, 2016

Forum on Immunopathological Diseases and Therapeutics

DOI: 10.1615/ForumImmunDisTher.v2.i1.90
pages 79-87

RKIP-1 and the Cell Cycle: Novel Insight Into Genomic Instability

Fahd Al-Mulla
Faculty of Medicine, Department of Pathology, Kuwait University Health Sciences Centre, Safat, Kuwait

Краткое описание

RKIP-1 has emerged as a significant metastasis suppressor in various cancers. Loss or reduced RKIP-1 expression has been well documented in aggressive and malignant cancers. In addition, recent data have stipulated a potential prognostication utility for the RKIP-1 expression level in colorectal, prostate, and gastrointestinal stromal tumors. This repressor and scaffold protein appear to be involved in a wide variety of intracellular signaling cascades ranging from the inhibition of Raf-1/MEK/ERK to the activation of the G protein–coupled receptor signaling pathway. However, its role in cellular growth, the cell cycle, and genomic instability has received little attention, especially in primary and immortalized (noncancerous) cells. We demonstrated that RKIP-1 depletion in HEK-293 cells caused a dramatic fast-forwarding or acceleration in the cell cycle at the S- and G2M phases, which may be a consequence to alteration in key cell cycle checkpoint proteins, such as Aurora B and NEK 6. Our data also demonstrate an increased trend for homozygosity accumulation after long-term culture of RKIP-1–depleted HEK-293 cells. This novel finding might have important ramifications to cancer development, particularly in the inactivation of tumor suppressor genes.

Articles with similar content:

Eupatilin Inhibits Proliferation of ras-Transformed Human Breast Epithelial (MCF-10A-ras) Cells
Journal of Environmental Pathology, Toxicology and Oncology, Vol.24, 2005, issue 4
Tae Young Oh, Do-Hee Kim, Hye-Kyung Na, Young-Joon Surh, Chang-Yell Shin
Resistance Mechanisms and Their Regulation in Lung Cancer
Critical Reviews™ in Oncogenesis, Vol.7, 1996, issue 3-4
Manfred Volm, Jurgen Mattern
Regulation and Activities of α-Fetoprotein
Critical Reviews™ in Eukaryotic Gene Expression, Vol.7, 1997, issue 1-2
Jen-Fu Chiu, Hongmin Chen, Jack O. Egan
Molecular Parameters of Hyperthermia for Radiosensitization
Critical Reviews™ in Eukaryotic Gene Expression, Vol.19, 2009, issue 3
Tej K. Pandita, Sukesh R. Bhaumik, Shruti Pandita
Inhibitors of Cell Cycle Kinases: Recent Advances and Future Prospects as Cancer Therapeutics
Critical Reviews™ in Oncogenesis, Vol.17, 2012, issue 2
Robert L. Sutherland, Andrew Stone, Elizabeth A . Musgrove