Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Forum on Immunopathological Diseases and Therapeutics
SJR: 0.309 SNIP: 0.041 CiteScore™: 0.18

ISSN Печать: 2151-8017
ISSN Онлайн: 2151-8025

Archives: Volume 1, 2010 to Volume 7, 2016

Forum on Immunopathological Diseases and Therapeutics

DOI: 10.1615/ForumImmunDisTher.2013008345
pages 1-10

Growth Factor Signaling Regulates Breast Cancer Stem Cells

Noriko Gotoh
Division of Cancer Cell Biology, Cancer Research Institute, Kanazawa University, Kakuma-machi, Ishikawa, 920-1192 Japan

Краткое описание

Accumulating evidence suggests that cancer stem cells−which make up only a small proportion of heterogeneous tumor cells−possess a greater ability to maintain tumor formation than other tumor cell types. Although the concept of cancer stem cells greatly impacts cancer biology and evokes a reconsideration of cancer treatment, the molecular mechanisms involved in the contribution of cancer stem cells to tumorigenesis remain obscure. We found that heregulin (HRG), a ligand for HER3/ErbB3, induced tumor sphere formation of a breast cancer stem cell (BCSC)-enriched population as well as in breast cancer cell lines. HRG-induced tumor sphere formation was reduced by treatment with inhibitors for phosphatidyl inositol 3-kinase (PI-3 kinase). Furthermore, we found that the expression of IL8, a regulator of self-renewal in BCSC-enriched populations, was induced by HRG through the activation of the PI3K/NF-κB pathway. These findings illustrate that HRG/ErbB3 signaling appears to maintain tumor sphere formation through a PI3K/NF-κB pathway in human breast cancer.

Articles with similar content:

Biological Characteristics of Cancers Involving the Serosal Cavities
Critical Reviews™ in Oncogenesis, Vol.13, 2007, issue 3
Ben Davidson
Role of Raf Kinase Inhibitor Protein in Pathophysiology of Prostate Cancer
Forum on Immunopathological Diseases and Therapeutics, Vol.2, 2011, issue 1
Evan T. Keller
Iron Chelation: Inhibition of Key Signaling Pathways in the Induction of the Epithelial Mesenchymal Transition in Pancreatic Cancer and Other Tumors
Critical Reviews™ in Oncogenesis, Vol.18, 2013, issue 5
Alexander Richardson, Des R. Richardson, Zaklina Kovacevic
Inhibition of Epithelial-to-Mesenchymal Transition (EMT) in Cancer by Nitric Oxide: Pivotal Roles of Nitrosylation of NF-κB, YY1 and Snail
Forum on Immunopathological Diseases and Therapeutics, Vol.3, 2012, issue 2
Stavroula Baritaki, Benjamin Bonavida
Molecular Parameters of Head and Neck Cancer Metastasis
Critical Reviews™ in Eukaryotic Gene Expression, Vol.21, 2011, issue 2
Sanjay L. Bhave, Theodoras N. Teknos, Quintin Pan