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Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Forum on Immunopathological Diseases and Therapeutics
SJR: 0.164 SNIP: 0.041 CiteScore™: 0.18

ISSN Печать: 2151-8017
ISSN Онлайн: 2151-8025

Archives: Volume 1, 2010 to Volume 7, 2016

Forum on Immunopathological Diseases and Therapeutics

DOI: 10.1615/ForumImmunDisTher.v2.i2.60
pages 145-159

Development and Application of Tissue Microarrays for Biomarker Studies

Erin Maresh
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Vei H. Mah
Department of Human Genetics, University of California at Los Angeles, Los Angeles, CA 90095; Department of Medicine, Division of Hematology-Oncology, UCLA David Geffen School of Medicine, Los Angeles, CA
Mohammad Alavi
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Angela Presson
Department of Biostatistics, UCLA School of Public Health, Los Angeles, CA, USA
Lora Bagryanova
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Nam K. Yoon
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
George Chang
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Yahya Elshimali
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Linda Shevlin
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Lily Zhang
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Longsheng Hong
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Samson Schatz
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Ai Li
Department of Biostatistics, UCLA School of Public Health, Los Angeles, CA, USA
Maoyong Fu
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Madhuri Wadehra
Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA; Center to Eliminate Cancer Health Disparities, Charles Drew University, Los Angeles, CA
David Chia
Department of Pathology, UCLA David Geffen School of Medicine at UCLA, Los Angeles, CA
Steve Horvath
Department of Biostatistics, UCLA School of Public Health; and Jonsson Comprehensive Cancer Center, Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Lee Goodglick
Jonsson Comprehensive Cancer Center, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA

Краткое описание

Traditional methods for analyzing large numbers of tissue samples require significant amounts of time, plentiful costly reagents, and highly skilled technicians. The development of tissue microarrays has provided an alternative method, allowing for high-throughput screening and analysis of hundreds of samples on a single slide. This has powerful implications for the identification and characterization of biomarkers involved in cancer progression and outcome. In this review, we describe methods of designing and constructing a tissue microarray, as well as techniques for quantifying and analyzing biomarker expression using a tissue microarray.

Ключевые слова: TMA, cancer, biomarker, prognostic marker, immunohistochemistry

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