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Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Forum on Immunopathological Diseases and Therapeutics
SJR: 0.309 SNIP: 0.041 CiteScore™: 0.18

ISSN Печать: 2151-8017
ISSN Онлайн: 2151-8025

Archives: Volume 1, 2010 to Volume 7, 2016

Forum on Immunopathological Diseases and Therapeutics

DOI: 10.1615/ForumImmunDisTher.v2.i2.80
pages 171-178

Clinical Significance of RKIP and Phosphorylated RKIP Expression in Human Cancers

Lee Goodglick
Jonsson Comprehensive Cancer Center, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Benjamin Bonavida
Department of Microbiology, Immunology, & Molecular Genetics, David Geffen School of Medicine, Johnson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, CA 90025-1747

Краткое описание

Recent findings have demonstrated the activity of a new gene product, RKIP, and its role in the regulation of cancer cell survival and response to apoptotic stimuli. RKIP has been implicated in certain cancers to be a suppressor of metastasis and of immune surveillance. However, in some tumors, the level of RKIP expression did not correlate with resistance or metastasis. Because most of these studies were performed with an antibody that detects both nonphosphorylated and inactive phosphorylated RKIP (pRKIP), it was possible that in some cancers, the expression of pRKIP may be implicated in the interpretation of the findings. A specific antiphospho antibody is available and detects pRKIP at serine 153 and can be used to determine the level of pRKIP in comparison to total RKIP. Studies in lung tumor tissue microarrays demonstrated that, although the total RKIP levels were not of prognostic significance, the levels of pRKIP had powerful predictive value for disease-specific survival. These findings are the first to demonstrate the involvement of pRKIP and its significance in cancer. These results also suggest that it might be fruitful and important to analyze both RKIP and pRKIP in all cancers.