Выходит 6 номеров в год
ISSN Печать: 1040-8401
ISSN Онлайн: 2162-6472
IF:
1.3
5-Year IF:
2.6
Eigenfactor:
0.00079
JCI:
0.24
SJR:
0.429
SNIP:
0.287
CiteScore™::
2.7
H-Index:
81
Indexed in
The Ambivalent Nature of T-Cell Infiltration in the Central Nervous System of Patients with Multiple Sclerosis
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Краткое описание
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) of presumed autoimmune origin. On the basis of the pathophysiology of MS, inflammatory reactions in the CNS are considered detrimental. Recent evidence suggests that the injured CNS can also benefit from immune activity. In this review, we will first provide an overview of the mechanisms by which immune cells contribute to CNS injury in MS. We will further review evidence supporting a neuroprotective role of CNS inflammation with special focus on the protective properties of autoimmune reactions. Finally, we discuss the proposed mechanisms by which autoreactive T cells exert protection in the CNS and how this protection is regulated.
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Tian Li, Rauvala Heikki, Gahmberg Carl G., Neuronal regulation of immune responses in the central nervous system, Trends in Immunology, 30, 2, 2009. Crossref
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Bogie Jeroen FJ, Stinissen Piet, Hellings Niels, Hendriks Jerome JA, Myelin-phagocytosing macrophages modulate autoreactive T cell proliferation, Journal of Neuroinflammation, 8, 1, 2011. Crossref
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Izquierdo-Altarejos Paula, Martínez-García Mar, Felipo Vicente, Extracellular Vesicles From Hyperammonemic Rats Induce Neuroinflammation in Cerebellum of Normal Rats: Role of Increased TNFα Content, Frontiers in Immunology, 13, 2022. Crossref