Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Immunology
Импакт фактор: 1.404 5-летний Импакт фактор: 3.347 SJR: 0.706 SNIP: 0.55 CiteScore™: 2.19

ISSN Печать: 1040-8401
ISSN Онлайн: 2162-6472

Выпуски:
Том 40, 2020 Том 39, 2019 Том 38, 2018 Том 37, 2017 Том 36, 2016 Том 35, 2015 Том 34, 2014 Том 33, 2013 Том 32, 2012 Том 31, 2011 Том 30, 2010 Том 29, 2009 Том 28, 2008 Том 27, 2007 Том 26, 2006 Том 25, 2005 Том 24, 2004 Том 23, 2003 Том 22, 2002 Том 21, 2001 Том 20, 2000 Том 19, 1999 Том 18, 1998 Том 17, 1997 Том 16, 1996 Том 15, 1995 Том 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v27.i1.20
pages 15-32

Mast Cell Homeostasis: A Fundamental Aspect of Allergic Disease

John J. Ryan
Department of Biology, Virginia Commonwealth University, Richmond, VA
Mohit Kashyap
Department of Biology, Virginia Commonwealth University, Richmond, VA
Daniel Bailey
Department of Biology, Virginia Commonwealth University, Richmond, VA
Sarah Kennedy
Department of Biology, Virginia Commonwealth University, Richmond, VA
Kelly Speiran
Department of Biology, Virginia Commonwealth University, Richmond, VA
Jennifer Brenzovich
Department of Biology, Virginia Commonwealth University, Richmond, VA
Brian Barnstein
Department of Biology, Virginia Commonwealth University, Richmond, VA
Carole Oskeritzian
Department of Biochemistry, Virginia Commonwealth University, Richmond, VA
Gregorio Gomez
Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA

Краткое описание

Mast cells are well known for their role in allergic disease and have recently been implicated in inflammatory disorders, including autoimmune arthritis, multiple sclerosis, and atherosclerosis. Although aberrant mast cell activation is the focus of many studies, much less is known about normal mast cell homeostasis. Because loss of the normal constraints on mast cell activation, proliferation, and survival may be central to disease etiology, understanding these issues warrants attention. This review summarizes the knowledge of mast cell homeostasis controlled by IgE and the regulatory cytokines IL-4, IL-10, and TGF-β1. Because each of these proteins plays an important role in immune responses tied to mast cell-associated disease, this group represents a potential set of factors altered in atopic or autoimmune patients. It is interesting to note, for example, that polymorphisms within each of these factors or their receptors are linked to allergic disease. By first understanding how cytokines and IgE regulate mast cell function and survival, we may then predict how these factors may function in disease onset and progression.


Articles with similar content:

Signal Transduction via MHC Class I Molecules in Endothelial and Smooth Muscle Cells
Critical Reviews™ in Immunology, Vol.23, 2003, issue 1-2
Elaine F. Reed
How Can the Innate Immune System Influence Autoimmunity in Type 1 Diabetes and Other Autoimmune Disorders?
Critical Reviews™ in Immunology, Vol.25, 2005, issue 3
L. Wen, F. S. Wong
Interaction between the Human NK Receptors and Their Ligands
Critical Reviews™ in Immunology, Vol.20, 2000, issue 3
Mar Vales-Gomez, Hugh Reyburn, Jack L. Strominger
Role of Activin A in the Induction of Foxp3+ and Foxp3− CD4+ Regulatory T Cells
Critical Reviews™ in Immunology, Vol.31, 2011, issue 1
Christoph Schramm, Samuel Huber
Neutrophil Apoptosis and Hypoxia
International Journal of Physiology and Pathophysiology, Vol.1, 2010, issue 4
Andrey Polyakov, Larissa Dyugovskaya