Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Immunology
Импакт фактор: 1.404 5-летний Импакт фактор: 3.347 SJR: 0.706 SNIP: 0.55 CiteScore™: 2.19

ISSN Печать: 1040-8401
ISSN Онлайн: 2162-6472

Выпуски:
Том 40, 2020 Том 39, 2019 Том 38, 2018 Том 37, 2017 Том 36, 2016 Том 35, 2015 Том 34, 2014 Том 33, 2013 Том 32, 2012 Том 31, 2011 Том 30, 2010 Том 29, 2009 Том 28, 2008 Том 27, 2007 Том 26, 2006 Том 25, 2005 Том 24, 2004 Том 23, 2003 Том 22, 2002 Том 21, 2001 Том 20, 2000 Том 19, 1999 Том 18, 1998 Том 17, 1997 Том 16, 1996 Том 15, 1995 Том 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v24.i3.30
12 pages

The Role of Dectin-1 in Antifungal Immunity

Jurgen Herre
Sir William Dunn School of Pathology, University of Oxford, UK
Janet A. Willment
Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
Siamon Gordon
Sir William Dunn School of Pathology, University of Oxford, UK
Gordon D. Brown
Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa

Краткое описание

β-Glucans are structural components of fungal cell walls, which have a stimulatory effect on the immune system. Although a number of receptors for these carbohydrates have been proposed, the recently identified C-type lectin-like receptor, Dectin-1, appears to play a central role. Dectin-1 is expressed on phagocytic cells, including macrophages and neutrophils, and mediates both the internalization and cellular responses to β-glucan, through unique mechanisms. Dectin-1 can recognize and respond to live fungal pathogens and is being increasingly appreciated as having a key role in the innate responses to these pathogens. In addition to its exogenous ligands, Dectin-1 can recognize an unidentified endogenous ligand on T cells and may act as a co-stimulatory molecule, although its function in these responses is less clear. This review will highlight the current knowledge of Dectin-1 and its potential role in antifungal immunity, as well as deficiencies in our understanding.


Articles with similar content:

Innate Immunity Induced by Fungal β-Glucans via Dectin-1 Signaling Pathway
International Journal of Medicinal Mushrooms, Vol.16, 2014, issue 1
Ha Won Kim, Dong Hee Lee
The Role of Plasmacytoid Dendritic Cell-Derived IFNα in Antiviral Immunity
Critical Reviews™ in Immunology, Vol.28, 2008, issue 1
Angela Dolganiuc, Gyongyi Szabo
The Goldilocks Conundrum: NLR Inflammasome Modulation of Gastrointestinal Inflammation during Inflammatory Bowel Disease
Critical Reviews™ in Immunology, Vol.36, 2016, issue 4
Veronica M. Ringel-Scaia, Irving C. Allen, Dylan K. McDaniel
Toll-Like Receptor Family in Domestic Animal Species
Critical Reviews™ in Immunology, Vol.28, 2008, issue 6
Federica Riva, Lauretta Turin
Tyrosine Phosphorylation in Immune Cells: Direct and Indirect Effects on Toll-Like Receptor-Induced Proinflammatory Cytokine Production
Critical Reviews™ in Immunology, Vol.29, 2009, issue 4
Pauline Johnson, Jennifer L. Cross