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ISSN Печать: 1040-8401
ISSN Онлайн: 2162-6472
Indexed in
Myeloid Hypoxia-Inducible Factors in Inflammatory Diseases
Краткое описание
Hypoxia inducible factors (HIF1 and HIF2) have emerged as central regulators of the activity of myeloid cells at inflammatory sites where O2 is frequently limited. Novel insights in the field have revealed that the expression of HIFs by myeloid cells is not exclusively induced by hypoxia but also in response to central inflammatory mediators independently of O2 shortage. This has substantially elevated the biological significance of HIFs in the context of inflammatory diseases. As a consequence, the loss of HIF1 or HIF2 in myeloid cells specifically compro-mises some of the processes driven by myeloid cells, such as bactericidal activity and myeloid invasion, as well as inflammation-associated detrimental consequences.
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Rosenow Anja, Noben Jean-Paul, Bouwman Freek G., Mariman Edwin C.M., Renes Johan, Hypoxia-mimetic effects in the secretome of human preadipocytes and adipocytes, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 1834, 12, 2013. Crossref
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Cellier Mathieu, Cell-Type Specific Determinants of NRAMP1 Expression in Professional Phagocytes, Biology, 2, 1, 2013. Crossref
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Hodgkinson Jordan, Grayfer Leon, Belosevic Miodrag, Biology of Bony Fish Macrophages, Biology, 4, 4, 2015. Crossref
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Liu Haiyun, Huang Lei, Bradley Jillian, Liu Kebin, Bardhan Kankana, Ron David, Mellor Andrew L., Munn David H., McGaha Tracy L., GCN2-Dependent Metabolic Stress Is Essential for Endotoxemic Cytokine Induction and Pathology, Molecular and Cellular Biology, 34, 3, 2014. Crossref