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Critical Reviews™ in Immunology

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ISSN Печать: 1040-8401

ISSN Онлайн: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

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Development and Functional Properties of Thymic and Extrathymic T Lymphocytes

Том 28, Выпуск 5, 2008, pp. 441-466
DOI: 10.1615/CritRevImmunol.v28.i5.40
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Краткое описание

Although vertebrate hematopoiesis is known to occur in a variety of locations, the differentiation of T lymphocytes takes place only in the thymus. Conversely, the only known function of the thymus is to produce T lymphocytes. As thymic function progressively diminishes with age in all individuals, and decreased thymic capacity has been linked to an impaired resistance to infections and cancer, increasing thymic function and/or extrathymic T-cell development could thus play an important role in health management in elderly subjects. However, it is currently unclear why the thymus is essential for T-cell development and precisely what is necessary to make a functional T lymphopoietic organ. In this review, we shall discuss the current literature on the similarities and differences between thymic and extrathymic T cells. A major conclusion is that innate T cells can be generated extrathymically, but only the thymus can support the development of classic adaptive T cells. Functional differences between thymic and extrathymic T cells provide a rationale for conservation of the thymus as the sole primary T lymphoid organ. These differences also have implications for the management of thymus involution.

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