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Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Immunology
Импакт фактор: 1.352 5-летний Импакт фактор: 3.347 SJR: 1.022 SNIP: 0.55 CiteScore™: 2.19

ISSN Печать: 1040-8401
ISSN Онлайн: 2162-6472

Выпуски:
Том 39, 2019 Том 38, 2018 Том 37, 2017 Том 36, 2016 Том 35, 2015 Том 34, 2014 Том 33, 2013 Том 32, 2012 Том 31, 2011 Том 30, 2010 Том 29, 2009 Том 28, 2008 Том 27, 2007 Том 26, 2006 Том 25, 2005 Том 24, 2004 Том 23, 2003 Том 22, 2002 Том 21, 2001 Том 20, 2000 Том 19, 1999 Том 18, 1998 Том 17, 1997 Том 16, 1996 Том 15, 1995 Том 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v28.i6.30
pages 513-538

Toll-Like Receptor Family in Domestic Animal Species

Lauretta Turin
Dipartimento di Patologia Animale, Igiene e Sanita' Pubblica Veterinaria, Universita' degli Studi di Milano, Italy
Federica Riva
Dipartimento di Patologia Animale, Igiene e Sanita' Pubblica Veterinaria, Universita' degli Studi di Milano, Italy

Краткое описание

Toll-like receptors (TLRs) arc a family of evolutionarily conserved, integral membrane glycoproteins that play a key role in innate immunity through the early sensing of pathogens and the initiation of appropriate responses. Each TLR receptor recognizes conserved motifs in macromolecular components from viruses and bacteria; the expression of the TLRs in cells and tissues therefore provide specific responses to pathogenic challenges. TLR activation addresses and reinforces both arms of the immune response (innate and adaptive), leading to prompt and specific activities toward pathogens. Although best studied in mouse and human genomes, orthologous TLRs have been identified in other vertebrates, including fish. Because of their early function of controlling immunity in animal species, TLR genes can be considered traits conferring disease resistance and should be considered suitable targets in the development of innovative immunotherapeutic. In the present review, the current knowledge on TLR receptors in domestic animal species is summarized and discussed from the point of view of the host-pathogen interaction.


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