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Critical Reviews™ in Immunology

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ISSN Печать: 1040-8401

ISSN Онлайн: 2162-6472

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DNA Motifs Suppressing TLR9 Responses

Том 26, Выпуск 6, 2006, pp. 527-544
DOI: 10.1615/CritRevImmunol.v26.i6.50
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Краткое описание

Immune cells respond to bacterial DNA containing unmethylated CpG motifs via Toll-like receptor 9 (TLR9). Given the apparent role of TLR9 in development of systemic lupus erythematosus (SLE), there is interest in the development of TLR9 inhibitors. TLR9-mediated responses are reported to be inhibited by a confusing variety of different DNA sequences and structures. To aid characterization, we have provisionally categorized TLR9-inhibitory oligodeoxynucleotides (ODN) into 4 classes, on the basis of sequence and probable mode of action. Class I are short G-rich ODN, which show sequence-specific inhibition of all TLR9 responses, and may be direct competitive inhibitors for DNA binding to TLR9. Class II are telomeric repeat motifs that inhibit STAT signaling, and thus are not specific to TLR9 responses. Because Class II ODN are generally made as 24-base phosphorothioate-modified ODN (PS-ODN), they also fall into Class IV, defined as long PS-ODN, which inhibit TLR9 responses in a sequence-nonspecific manner. Class III includes oligo (dG) that forms a 4-stranded structure and inhibits DNA uptake. The Class I G-rich motifs show the most promise as selective and potent TLR9 inhibitors for therapeutic applications.

ЦИТИРОВАНО В
  1. Ito Yusuke, Shigemori Suguru, Sato Takashi, Shimazu Tomoyuki, Hatano Konomi, Otani Hajime, Kitazawa Haruki, Shimosato Takeshi, Class I/II hybrid inhibitory oligodeoxynucleotide exerts Th1 and Th2 double immunosuppression, FEBS Open Bio, 3, 1, 2013. Crossref

  2. de Vries I. Jolanda M., Tel Jurjen, Benitez-Ribas Daniel, Torensma Ruurd, Figdor Carl G., Prophylactic vaccines mimic synthetic CpG oligonucleotides in their ability to modulate immune responses, Molecular Immunology, 48, 6-7, 2011. Crossref

  3. Hua Chunyan, Yang Yonghong, Sun Lin, Dou Huan, Tan Renxiang, Hou Yayi, Chaetoglobosin F, a small molecule compound, possesses immunomodulatory properties on bone marrow-derived dendritic cells via TLR9 signaling pathway, Immunobiology, 218, 3, 2013. Crossref

  4. Yang Yonghong, Dou Huan, Li Xiaoqin, Song Yuxian, Gong Wei, Tan Renxiang, Hou Yayi, FC-98 Regulates TLR9-Mediated of CXCL-10 Expression in Dendritic Cells via MAPK and STAT1 Signaling Pathway, BioMed Research International, 2014, 2014. Crossref

  5. Yang Guang, Wan Min, Zhang Yongsheng, Sun Luguo, Sun Ran, Hu Dali, Zhou Xiaojing, Wang Li, Wu Xiuli, Wang Liying, Yu Yongli, Inhibition of a C-rich oligodeoxynucleotide on activation of immune cells in vitro and enhancement of antibody response in mice, Immunology, 131, 4, 2010. Crossref

  6. Peng Songming, Derrien Thomas L., Cui Jinhui, Xu Chuanying, Luo Dan, From cells to DNA materials, Materials Today, 15, 5, 2012. Crossref

  7. Peter Mirjam, Bode Konrad, Lipford Grayson B., Eberle Florian, Heeg Klaus, Dalpke Alexander H., Characterization of suppressive oligodeoxynucleotides that inhibit Toll-like receptor-9-mediated activation of innate immunity, Immunology, 123, 1, 2008. Crossref

  8. Trieu Angela, Bokil Nilesh, Dunn Jasmyn A, Roberts Tara L, Xu Damo, Liew Foo Y, Hume David A, Stacey Katryn J, Sweet Matthew J, TLR9‐independent effects of inhibitory oligonucleotides on macrophage responses to S. typhimurium , Immunology & Cell Biology, 87, 3, 2009. Crossref

  9. Sun Ran, Sun Luguo, Bao Musheng, Zhang Yongsheng, Wang Li, Wu Xiuli, Hu Dali, Liu Yongjun, Yu Yongli, Wang Liying, A human microsatellite DNA-mimicking oligodeoxynucleotide with CCT repeats negatively regulates TLR7/9-mediated innate immune responses via selected TLR pathways, Clinical Immunology, 134, 3, 2010. Crossref

  10. Weng Lin-Hsiu, Wang Ching-Jen, Ko Jih-Yang, Sun Yi-Chih, Wang Feng-Sheng, Control of Dkk-1 ameliorates chondrocyte apoptosis, cartilage destruction, and subchondral bone deterioration in osteoarthritic knees, Arthritis & Rheumatism, 62, 5, 2010. Crossref

  11. Wikström F. Hasslung, Fossum C., Fuxler L., Kruse R., Lövgren T., Cytokine induction by immunostimulatory DNA in porcine PBMC is impaired by a hairpin forming sequence motif from the genome of Porcine Circovirus type 2 (PCV2), Veterinary Immunology and Immunopathology, 139, 2-4, 2011. Crossref

  12. Zhang Yong-Sheng, Wu Xiu-Li, Wang Ying, Sun Ran, Yu Yong-Li, Wang Li-Ying, Structure–activity relationship of a guanine-free oligodeoxynucleotide as immunopotent inhibitor, International Immunopharmacology, 13, 4, 2012. Crossref

  13. Matesic Damir, Lenert Aleksander, Lenert Petar, Modulating Toll-like Receptor 7 and 9 Responses as Therapy for Allergy and Autoimmunity, Current Allergy and Asthma Reports, 12, 1, 2012. Crossref

  14. Bates Paula J., Laber Damian A., Miller Donald M., Thomas Shelia D., Trent John O., Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer, Experimental and Molecular Pathology, 86, 3, 2009. Crossref

  15. Avalos Ana M., Ploegh Hidde L., Competition by inhibitory oligonucleotides prevents binding of CpG to C-terminal TLR9, European Journal of Immunology, 41, 10, 2011. Crossref

  16. Byadgi Omkar, Chang Chin-I, Lee Jai-Wei, Huang Chih-Chun Jean, Cheng Ta-Chih, Immunostimulatory effects of non-CpG oligodeoxynucleotides on cobia (Rachycentron canadum), Aquaculture International, 24, 2, 2016. Crossref

  17. Bayik Defne, Gursel Ihsan, Klinman Dennis M., Structure, mechanism and therapeutic utility of immunosuppressive oligonucleotides, Pharmacological Research, 105, 2016. Crossref

  18. Kobayashi Koichi, Koyama Kazuya, Suzukawa Maho, Igarashi Sayaka, Hebisawa Akira, Nagase Takahide, Ohta Ken, Epithelial-mesenchymal transition promotes reactivity of human lung adenocarcinoma A549 cells to CpG ODN, Allergology International, 65, 2016. Crossref

  19. Lenert Petar S., Classification, Mechanisms of Action, and Therapeutic Applications of Inhibitory Oligonucleotides for Toll-Like Receptors (TLR) 7 and 9, Mediators of Inflammation, 2010, 2010. Crossref

  20. Tuomela Johanna M., Sandholm Jouko A., Kaakinen Mika, Hayden Katherine L., Haapasaari Kirsi-Maria, Jukkola-Vuorinen Arja, Kauppila Joonas H., Lehenkari Petri P., Harris Kevin W., Graves David E., Selander Katri S., Telomeric G-quadruplex-forming DNA fragments induce TLR9-mediated and LL-37-regulated invasion in breast cancer cells in vitro, Breast Cancer Research and Treatment, 155, 2, 2016. Crossref

  21. Xu Y, Liu J, Hua L, Xiao Y, Tian Y, Guo S, Zhang X, He C, Wang L, Yu Y, An immune regulatory CCT repeat containing oligodeoxynucleotide capable of causing hair loss in male mice, Human & Experimental Toxicology, 35, 11, 2016. Crossref

  22. Kostyuk Svetlana V., Porokhovnik Lev N., Ershova Elizaveta S., Malinovskaya Elena M., Konkova Marina S., Kameneva Larisa V., Dolgikh Olga A., Veiko Vladimir P., Pisarev Vladimir M., Martynov Andrew V., Sergeeva Vasilina A., Kaliyanov Andrew A., Filev Anton D., Chudakova Julia M., Abramova Margarita S., Kutsev Serguey I., Izhevskaya Vera L., Veiko Nataliya N., Changes ofKEAP1/NRF2andIKB/NF-κB Expression Levels Induced by Cell-Free DNA in Different Cell Types, Oxidative Medicine and Cellular Longevity, 2018, 2018. Crossref

  23. Kaminski John J., Schattgen Stefan A., Tzeng Te-Chen, Bode Christian, Klinman Dennis M., Fitzgerald Katherine A., Synthetic Oligodeoxynucleotides Containing Suppressive TTAGGG Motifs Inhibit AIM2 Inflammasome Activation, The Journal of Immunology, 191, 7, 2013. Crossref

  24. Schiller Martin, Parcina Marijo, Heyder Petra, Foermer Sandra, Ostrop Jenny, Leo Albrecht, Heeg Klaus, Herrmann Martin, Lorenz Hanns-Martin, Bekeredjian-Ding Isabelle, Induction of Type I IFN Is a Physiological Immune Reaction to Apoptotic Cell-Derived Membrane Microparticles, The Journal of Immunology, 189, 4, 2012. Crossref

  25. An Beiying, Zhu Shan, Li Tete, Wu Jing, Zang Guoxia, Lv Xinping, Qiao Yuan, Huang Jing, Shao Yan, Cui Jiuwei, Liu Yong-Jun, Chen Jingtao, A Dual TLR7/TLR9 Inhibitor HJ901 Inhibits ABC-DLBCL Expressing the MyD88 L265P Mutation, Frontiers in Cell and Developmental Biology, 8, 2020. Crossref

  26. Gooshe Maziar, Abdolghaffari Amir Hossein, Gambuzza Maria Elsa, Rezaei Nima, The role of Toll-like receptors in multiple sclerosis and possible targeting for therapeutic purposes, Reviews in the Neurosciences, 2014. Crossref

  27. Lenert P, Nucleic acid sensing receptors in systemic lupus erythematosus: development of novel DNA- and/or RNA-like analogues for treating lupus, Clinical and Experimental Immunology, 161, 2, 2010. Crossref

  28. Henault Jill, Martinez Jennifer, Riggs Jeffrey M., Tian Jane, Mehta Payal, Clarke Lorraine, Sasai Miwa, Latz Eicke, Brinkmann Melanie M., Iwasaki Akiko, Coyle Anthony J., Kolbeck Roland, Green Douglas R., Sanjuan Miguel A., Noncanonical Autophagy Is Required for Type I Interferon Secretion in Response to DNA-Immune Complexes, Immunity, 37, 6, 2012. Crossref

  29. Valentin Roxane, Wong Christophe, Alharbi Arwaf S, Pradeloux Solène, Morros Makala P, Lennox Kim A, Ellyard Julia I, Garcin Aurélie J, Ullah Tomalika R, Kusuma Gina D, Pépin Geneviève, Li Hong-Mei, Pearson Jaclyn S, Ferrand Jonathan, Lim Rebecca, Veedu Rakesh N, Morand Eric F, Vinuesa Carola G, Behlke Mark A, Gantier Michael P, Sequence-dependent inhibition of cGAS and TLR9 DNA sensing by 2′-O-methyl gapmer oligonucleotides, Nucleic Acids Research, 49, 11, 2021. Crossref

  30. Roberts Tara L., Dunn Jasmyn A., Sweet Matthew J., Hume David A., Stacey Katryn J., The immunostimulatory activity of phosphorothioate CpG oligonucleotides is affected by distal sequence changes, Molecular Immunology, 48, 8, 2011. Crossref

  31. Wang Jing, Gan Mingzhe, DNA Nanoflowers’ Amelioration of Lupus Symptoms in Mice via Blockade of TLR7/9’s Signal, International Journal of Molecular Sciences, 23, 24, 2022. Crossref

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