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Critical Reviews™ in Immunology
Импакт фактор: 1.352 5-летний Импакт фактор: 3.347 SJR: 1.022 SNIP: 0.55 CiteScore™: 2.19

ISSN Печать: 1040-8401
ISSN Онлайн: 2162-6472

Выпуски:
Том 39, 2019 Том 38, 2018 Том 37, 2017 Том 36, 2016 Том 35, 2015 Том 34, 2014 Том 33, 2013 Том 32, 2012 Том 31, 2011 Том 30, 2010 Том 29, 2009 Том 28, 2008 Том 27, 2007 Том 26, 2006 Том 25, 2005 Том 24, 2004 Том 23, 2003 Том 22, 2002 Том 21, 2001 Том 20, 2000 Том 19, 1999 Том 18, 1998 Том 17, 1997 Том 16, 1996 Том 15, 1995 Том 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v24.i1.30
20 pages

TCR Trafficking in Resting and Stimulated T Cells

Carsten Geisler
Institute of Medical Microbiology and Immunology, University of Copenhagen, Denmark

Краткое описание

Dynamic regulation of TCR expression levels plays important roles in modulating T-cell responses during T-cell development and in mature T cells. TCR expression levels are determined by the rate constants for synthesis, endocytosis, recycling, and degradation. This review examines the rate constants, the molecular mechanisms, and the proposed physiological roles of TCR trafficking in resting and stimulated T cells. In resting T cells, the TCR slowly and constitutively cycles between the plasma membrane and the intracellular compartment. Constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif in the TCR subunit CD3g and might play a role in quality control of the TCR. TCR triggering induces an enhancement in the endocytic rate constant leading to TCR down-regulation. At least two pathways exist for endocytosis of triggered TCR. One is dependent on protein tyrosine kinase activity leading to ubiquitination of the TCR, whereas the other is dependent on protein kinase C (PKC)-mediated activation of the diL motif. In addition, nontriggered TCR are endocytosed (co-modulated) by the PKC/CD3g-dependent pathway. TCR down-regulation might attenuate signaling and/or might ensure an internal store of TCR that can be rerouted to the immunological synapse during the encounter with an antigen-presenting cell.


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