Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Immunology
Импакт фактор: 1.352 5-летний Импакт фактор: 3.347 SJR: 0.657 SNIP: 0.55 CiteScore™: 2.19

ISSN Печать: 1040-8401
ISSN Онлайн: 2162-6472

Выпуски:
Том 39, 2019 Том 38, 2018 Том 37, 2017 Том 36, 2016 Том 35, 2015 Том 34, 2014 Том 33, 2013 Том 32, 2012 Том 31, 2011 Том 30, 2010 Том 29, 2009 Том 28, 2008 Том 27, 2007 Том 26, 2006 Том 25, 2005 Том 24, 2004 Том 23, 2003 Том 22, 2002 Том 21, 2001 Том 20, 2000 Том 19, 1999 Том 18, 1998 Том 17, 1997 Том 16, 1996 Том 15, 1995 Том 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.2016015691
pages 433-449

Mechanisms of Cytotoxic Lymphocyte-Mediated Apoptosis and Relationship with the Tumor Suppressor p53

Jerome Thiery
INSERM, U1186, Villejuif, France; Gustave Roussy Cancer Campus, Villejuif, France; and University Paris-Saclay, Faculty of Medicine, Le Kremlin Bicetre, France
Thouraya Ben Safta
INSERM, U1186, Villejuif, France; Gustave Roussy Cancer Campus, Villejuif, France; and University Paris-Saclay, Faculty of Medicine, Le Kremlin Bicetre, France
Linda Ziani
INSERM, U1186, Villejuif, France; Gustave Roussy Cancer Campus, Villejuif, France; and University Paris-Saclay, Faculty of Medicine, Le Kremlin Bicetre, France
Salem Chouaib
Thumbay Research Institute for Precision Medicine, Gulf Medical University, Ajman 4184, United Arab Emirates; INSERM UMR 1186, Integrative Tumor Immunology and Genetic Oncology, Gustave Roussy, EPHE, Faculty de Médecine University Paris-Sud, University Paris-Saclay, Villejuif F-94805, France

Краткое описание

Cytotoxic T lymphocytes and natural killer cells are key effector cells in the immune response against intracellular infection and transformed cells. These killer cells induce multiple programs of cell death to achieve their function of eliminating their targets. In this review, we summarize our current understanding of the signaling pathways involved in target cells apoptosis triggered by the cytotoxic effector cells. We also discuss the role of an important player in the field of apoptosis, the well-known p53 tumor suppressor, in the modulation of cytotoxic lymphocyte-mediated cell death.


Articles with similar content:

Inhibitory Receptor-Mediated Regulation of Natural Killer Cells
Critical Reviews™ in Immunology, Vol.34, 2014, issue 6
Beena Jeevan-Raj , Camille Grandclement, Werner Held, Elisenda Alari-Pahissa
Proteases and Cell-Mediated Cytotoxicity
Critical Reviews™ in Immunology, Vol.18, 1998, issue 3
R. Chris Bleackley, Alison J. Darmon
Modulation of Innate Immune Responses by Hantaviruses
Critical Reviews™ in Immunology, Vol.30, 2010, issue 6
Andreas Rang
Regulation of Regulatory T Cells: Role of Dendritic Cells and Toll-Like Receptors
Critical Reviews™ in Immunology, Vol.26, 2006, issue 4
Dieter Kabelitz, Daniela Wesch, Hans-Heinrich Oberg
Toll-like Receptor Modulation in Head and Neck Cancer
Critical Reviews™ in Immunology, Vol.28, 2008, issue 3
Barbara Wollenberg, Sandra Wulff, Ralph Pries