Доступ предоставлен для: Guest
Critical Reviews™ in Immunology

Выходит 6 номеров в год

ISSN Печать: 1040-8401

ISSN Онлайн: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

The Role of Protein Kinase A and A-Kinase Anchoring Proteins in Modulating T-Cell Activation: Progress and Future Directions

Том 26, Выпуск 2, 2006, pp. 113-132
DOI: 10.1615/CritRevImmunol.v26.i2.20
Get accessGet access

Краткое описание

Protein kinase A (PKA) is a broad-specificity serine/threonine protein kinase whose spatial and temporal regulation is maintained through interactions with A-kinase anchoring proteins (AKAPs). Subcellular localization of AKAPs through unique targeting domains provides a mechanism by which PKA can respond to localized microdomains of cyclic AMP (cAMP) and phosphorylate nearby substrates.1 For nearly 40 years, cAMP has been known to be a potent modulator of the immune system. cAMP levels are regulated by G-protein−coupled receptors, adenylyl cyclases (AC), and phosphodiesterases (PDEs). This review discusses recent progress made in the discovery of PKA substrates in T lymphocytes and in the identification of AKAPs in T lymphocytes. Because PKA is activated by cAMP, generation and maintenance of cAMP in T cells is also discussed. These findings are framed in the context of understanding the complexity of cAMP and, thus, PKA signaling and are intended to provide the reader with an overview of current literature, as well as an awareness of questions and concerns to consider.

ЦИТИРОВАНО В
  1. Ghanemi Abdelaziz, Targeting G protein coupled receptor-related pathways as emerging molecular therapies, Saudi Pharmaceutical Journal, 23, 2, 2015. Crossref

  2. Kang Sang Sun, Shin Sung Hwa, Phosphorylation of human chromosome maintenance 1 mediates association with 14-3-3 proteins, Animal Cells and Systems, 17, 3, 2013. Crossref

  3. Fraser Christopher C., G Protein–Coupled Receptor Connectivity to NF-κB in Inflammation and Cancer, International Reviews of Immunology, 27, 5, 2008. Crossref

  4. Fiedler Sarah E., Schillace Robynn V., Daniels Crystal J., Andrews Sarah F., Carr Daniel W., Myeloid translocation gene 16b is a dual A-kinase anchoring protein that interacts selectively with plexins in a phospho-regulated manner, FEBS Letters, 584, 5, 2010. Crossref

  5. Cytryńska Małgorzata, Zdybicka-Barabas Agnieszka, Jakubowicz Teresa, Protein kinase A activity and protein phosphorylation in the haemocytes of immune-challenged Galleria mellonella larvae, Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 148, 1, 2007. Crossref

  6. Salinthone Sonemany, Schillace Robynn V., Tsang Catherine, Regan John W., Bourdette Dennis N., Carr Daniel W., Lipoic acid stimulates cAMP production via G protein-coupled receptor-dependent and -independent mechanisms, The Journal of Nutritional Biochemistry, 22, 7, 2011. Crossref

  7. Patrussi Laura, Mariggio' Stefania, Paccani Silvia Rossi, Capitani Nagaja, Zizza Pasquale, Corda Daniela, Baldari Cosima T., Glycerophosphoinositol-4-phosphate enhances SDF-1α-stimulated T-cell chemotaxis through PTK-dependent activation of Vav, Cellular Signalling, 19, 11, 2007. Crossref

  8. Schillace Robynn V., Miller Casey L., Pisenti Neal, Grotzke Jeff E., Swarbrick Gwendolyn M., Lewinsohn David M., Carr Daniel W., Unutmaz Derya, A-Kinase Anchoring in Dendritic Cells Is Required for Antigen Presentation, PLoS ONE, 4, 3, 2009. Crossref

  9. Wehbi Vanessa L., Taskén Kjetil, Molecular Mechanisms for cAMP-Mediated Immunoregulation in T cells – Role of Anchored Protein Kinase A Signaling Units, Frontiers in Immunology, 7, 2016. Crossref

  10. Vang Amanda G., Ben-Sasson Shlomo Z., Dong Hongli, Kream Barbara, DeNinno Michael P., Claffey Michelle M., Housley William, Clark Robert B., Epstein Paul M., Brocke Stefan, Unutmaz Derya, PDE8 Regulates Rapid Teff Cell Adhesion and Proliferation Independent of ICER, PLoS ONE, 5, 8, 2010. Crossref

  11. Bielekova Bibiana, Richert Nancy, Howard Thomas, Packer Amy N, Blevins Gregg, Ohayon Joan, McFarland Henry F, Stürzebecher Claus-Steffen, Martin Roland, Treatment with the phosphodiesterase type-4 inhibitor rolipram fails to inhibit blood—brain barrier disruption in multiple sclerosis, Multiple Sclerosis Journal, 15, 10, 2009. Crossref

  12. Fiedler Sarah E., Yadav Vijayshree, Kerns Amelia R., Tsang Catherine, Markwardt Sheila, Kim Edward, Spain Rebecca, Bourdette Dennis, Salinthone Sonemany, Lipoic Acid Stimulates cAMP Production in Healthy Control and Secondary Progressive MS Subjects, Molecular Neurobiology, 55, 7, 2018. Crossref

  13. Pérez-Lorenzo M J, Galindo M, García-González A J, Criado G, Increased expression of A-kinase anchoring proteins in T cells from systemic lupus erythematosus patients, Journal of Translational Medicine, 8, S1, 2010. Crossref

  14. Vang Amanda G., Housley William, Dong Hongli, Basole Chaitali, Ben-Sasson Shlomo Z., Kream Barbara E., Epstein Paul M., Clark Robert B., Brocke Stefan, Regulatory T-cells and cAMP suppress effector T-cells independently of PKA–CREM/ICER: a potential role for Epac, Biochemical Journal, 456, 3, 2013. Crossref

  15. Morovic-Vergles Jadranka, Culo Melanie Ivana, Gamulin Stjepan, Culo Filip, Cyclic adenosine 5′-monophosphate in synovial fluid of rheumatoid arthritis and osteoarthritis patients, Rheumatology International, 29, 2, 2008. Crossref

  16. Ross Jeremy A., Cheng Hanyin, Nagy Zsuzsanna S., Frost Jeffrey A., Kirken Robert A., Protein Phosphatase 2A Regulates Interleukin-2 Receptor Complex Formation and JAK3/STAT5 Activation, Journal of Biological Chemistry, 285, 6, 2010. Crossref

  17. Mosenden Randi, Taskén Kjetil, Cyclic AMP-mediated immune regulation — Overview of mechanisms of action in T cells, Cellular Signalling, 23, 6, 2011. Crossref

  18. Sarkar Kaushik, Debsarma Biswajit, Das Rajesh Kumar, 2D QSAR of 3-(Piperidin-1-yl)-5,6,7,8-Tetrahydropyrido[3,4-b] Pyrazine Derivatives With GPCR-6 Inhibitory Activity, International Journal of Quantitative Structure-Property Relationships, 7, 1, 2022. Crossref

  19. Ainatzoglou Alexandra, Stamoula Eleni, Dardalas Ioannis, Siafis Spyridon, Papazisis Georgios, The Effects of PDE Inhibitors on Multiple Sclerosis: a Review of in vitro and in vivo Models, Current Pharmaceutical Design, 27, 20, 2021. Crossref

Статьи, принятые к публикации

Identification of a novel five-gene prognostic model for laryngeal cancer associated with mitophagy using integrated bioinformatics analysis and experimental verification Dong Song, Lun Dong, Mei Wang, Xiaoping Gao Function of steroid receptor coactivators (SRCs) in T cells and cancers: Implications for cancer immunotherapy Wencan Zhang, Xu Cao, Hongmin Wu, Xiancai Zhong, Yun Shi, Zuoming Sun Electroacupuncture Alleviates Ischemic Stroke by Activating the mTOR/SREBP1 Pathway Jiawang Lang, Jianchang Luo, Luodan Wang, Wenbin Xu, Jie Jia, Zhipeng Zhao, Boxu Lang KIAA1429 induces the m6A modification of LINC01106 to enhance the malignancy of lung adenocarcinoma cell via JAK/STAT3 pathway Di Xu, Ziming Wang, Fajiu Li Effect of p-estrogen receptor at serine on its function and breast growth Yuan Liang, Junhui Qin, Tiancheng Ma, Tong Yang, Zhenyu Ke, Ruian Wang Mechanistic Insights into Tanshinone IIA in the Amelioration of Post-Thyroidectomy Hypoparathyroidism Xiaoyu Qian, Lin Li, Liang Chen, Chao Shen, Jian Tang MiRNA let-7d-5p alleviates inflammatory responses by targeting Map3k1 and inactivating ERK/p38 MAPK signaling in microglia Fan Fang, Cheng Chen Role of Natural Killer Cells as Cell-Based Immunotherapy in Oral Tumor Eradication and Differentiation Both In Vivo and In Vitro Kawaljit Kaur, Anahid Jewett The Current and Future States of Natural Killer Cell-Based Immunotherapy in Hepatocellular Carcinoma Tu Nguyen, Po-Chun Chen, Janet Pham, Kawaljit Kaur, Steven Raman, Anahid Jewett, Jason Chiang Phillygenin alleviated arthritis through the inhibition of NLRP3 inflammasome and Ferroptosis by AMPK Jianghui Wang, Shufang Ni, Kai Zheng, Yan Zhao, peihong zhang, Hong Chang The value of systemic immune-inflammation index and T cell subsets in the severity and prognosis of sepsis Hao Zhou Efficacy and Nuances of Precision Molecular Engineering for Hodgkin's Disease to a Gene Therapeutic Approach Muhammad Imran Qadir, Bilal Ahmed, Nadir Hussain Serum interleukin 6 and ferritin levels are the independent risk factors for pneumonia in elderly patients Hao Yuan, Jing Tian, Lu Wen Exploration of diagnostic markers associated with inflammation in chronic kidney disease (CKD) based on WGCNA and machine learning Qianjia Wu, Yang Yang, Chongze Lin Clinical significance of serum CTRP3 level in the prediction of cardiac dysfunction and intestinal mucosal barrier dysfunction in patients with severe acute pancreatitis Qiang Shao, Lin Sun The protective effect and mechanism of mild hypothermia on pig lung injury after cardiopulmonary resuscitation Jinlin Ren, Fangfang Zhu, Dongdong Sang, Mulin Cong, Shujuan Jiang Exploring mechanism of Zilongjin in treating lung adenocarcinoma based on network pharmacology combined with experimental verification Kang Zhang, Xiaoqun Chen Gastric Cancer Immune Subtypes and Prognostic Modeling: Insights from Aging-Related Genes Analysis Jian Shen, Minzhe Li Effects of different doses of dexmedetomidine on the prevention of postoperative sleep disturbance and serum neurotransmitter level in patients under general anesthesia Huifei Lu, Fei He, Ying Huang, Zhongliang Wei Identification of key ubiquitination-related genes and their associated with immune infiltration in osteoarthritis based on mRNA-miRNA network Dalu Yuan, Hailiang Shen, Lina Bai, Menglin Li, Qiujie Ye Diagnostic and Prognostic value of peripheral neutrophil CD64 index in elderly patients with community-acquired pneumonia Yan Li, Jing Zhang, Suhang Wang, Jie Cao Identification of Metabolism-Related Prognostic Biomarkers and Immune Features of Head and Neck Squamous Cell Carcinoma Rongjin Zhou, Junguo Wang Downregulation of miR-503-5p promotes the development of pancreatic cancer via targeting cyclin E2 Fei Li, Ying-pei Ling, Pan Wang, Shi-cheng Gu, Hao Jiang, Jie Zhu
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции Цены и условия подписки Begell House Контакты Language English 中文 Русский Português German French Spain