Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Immunology
Импакт фактор: 1.404 5-летний Импакт фактор: 3.347 SJR: 0.706 SNIP: 0.55 CiteScore™: 2.19

ISSN Печать: 1040-8401
ISSN Онлайн: 2162-6472

Выпуски:
Том 40, 2020 Том 39, 2019 Том 38, 2018 Том 37, 2017 Том 36, 2016 Том 35, 2015 Том 34, 2014 Том 33, 2013 Том 32, 2012 Том 31, 2011 Том 30, 2010 Том 29, 2009 Том 28, 2008 Том 27, 2007 Том 26, 2006 Том 25, 2005 Том 24, 2004 Том 23, 2003 Том 22, 2002 Том 21, 2001 Том 20, 2000 Том 19, 1999 Том 18, 1998 Том 17, 1997 Том 16, 1996 Том 15, 1995 Том 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v18.i5.30
pages 449-484

DNA Vaccines

Wayne C. Lai
Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235
Michael Bennett
Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235

Краткое описание

DNA vaccination against infectious diseases has created a new field of applied molecular immunology. cDNAs for 'protective' protein epitopes can be inserted into vectors containing strong mammalian promoters for high expression. Here we discuss the mechanisms of DNA vaccination and the successful and sometimes unsuccessful applications of DNA vaccination to protect animals against many different viral, bacterial mycoplasmal, protozoal, and worm infections or infestations. DNA immunization has been used to prevent or inhibit tumor development and to inhibit IgE responses by diverting the immune response from Th2 to Th1 helper cell dominance. Advantages and disadvantages of a variety of routes of administration and methods of immunization discussed include the use of the 'gene gun', the delivery of genes by aerosols, and deliberate induction of injury to muscles prior to injection of DNA to enhance gene expression. Vaccination performed using DNA without knowing beforehand the protective epitopes, using 'expression library immunization', is discussed. While this field is bound to expand rapidly for future clinical applications, we try to point out potential pitfalls as well as advantages of this relatively new technology.


Articles with similar content:

Glycosylated Cationic Liposomes for Cell-Selective Gene Delivery
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.19, 2002, issue 2
Junzo Nakamura, Mitsuru Hashida, Koyo Nishida, Fumiyoshi Yamashita
Direct Current Helium Plasma for In vivo Delivery of Plasmid DNA Encoding Erythropoietin to Murine Skin
Plasma Medicine, Vol.7, 2017, issue 3
Richard J. Connolly, Mark J. Jaroszeski, Andrew Hoff, Reginald Atkins, Taryn Harvey-Chapman
Targeted Gene Delivery: A Two-Pronged Approach
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.17, 2000, issue 4
Austin Bailey, Sean M. Sullivan, Khursheed Anwer
Mucosal Immunization: A Review of Strategies and Challenges
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.31, 2014, issue 4
Mohan N. Rathi, Hinal Patel, Chetan Yewale, Ambikanandan Misra
Novel Strategies Using DNA for the Induction of Mucosal Immunity
Critical Reviews™ in Immunology, Vol.19, 1999, issue 4
Heather L. Davis, Michael J. McCluskie