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Critical Reviews™ in Immunology

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ISSN Онлайн: 2162-6472

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TAOK3, a Regulator of LCK–SHP-1 Crosstalk during TCR Signaling

Том 39, Выпуск 1, 2019, pp. 59-81
DOI: 10.1615/CritRevImmunol.2019030480
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Краткое описание

Signaling from the T cell receptor for antigen turns on the physiological response of a T cell. The canonical TCR signaling pathway relies on early activation of the Src kinase LCK. This step initiates a cascade of events that lead not only to the phenotypic changes that characterize effector T cells but also to the activation of negative regulatory mechanisms that stop early TCR signaling. These mechanisms ensure qualitative and quantitative fine-tuning of T cell activation. The tyrosine phosphatase SHP-1 is a key player in the downregulation of LCK activation. In this review, we focus on the crosstalk between LCK and SHP-1 and, based on recent data, we introduce the putative kinase TAOK3 as an important regulator of this crosstalk. Given the widespread expression of TAOK3 and SHP-1, we propose that the function of TAOK3 extends beyond T cells and may be fundamental in the regulation of early signaling from receptors that utilize Src kinases.

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ЦИТИРОВАНО В
  1. Hu Chun, Feng Pan, Yang Qian, Xiao Lin, Clinical and Neurobiological Aspects of TAO Kinase Family in Neurodevelopmental Disorders, Frontiers in Molecular Neuroscience, 14, 2021. Crossref

  2. Iden Marissa, Tsaih Shirng-Wern, Huang Yi-Wen, Liu Pengyuan, Xiao Meizhu, Flister Michael J., Rader Janet S., Multi-omics mapping of human papillomavirus integration sites illuminates novel cervical cancer target genes, British Journal of Cancer, 125, 10, 2021. Crossref

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