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Critical Reviews™ in Immunology

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ISSN Печать: 1040-8401

ISSN Онлайн: 2162-6472

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Activation of Mammalian Toll-like Receptors by Endogenous Agonists

Том 23, Выпуск 1-2, 2003, 30 pages
DOI: 10.1615/CritRevImmunol.v23.i12.20
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Краткое описание

Toll-like receptors activate innate and adaptive immune systems in mammals. This ancient family of receptors has been evolving since before the taxonomic split between the plant and animal kingdoms. The discovery of the mammalian Toll-like receptors was heralded as confirmation of a predicted biological system explicitly designed to detect exogenous molecules from micro-organisms. However, there is accumulating evidence that Toll-like receptors also detect endogenous agonists, such as the degradation products of macromolecules, products of proteolytic cascades, intracellular components of ruptured cells, and products of genes that are activated by inflammation. Here we review endogenous models of Toll-like receptor activation, a subject of extensive debate. Endogenous activation of mammalian Toll-like receptors may provide key insights for the treatment of multiple conditions, from atherosclerosis to transplant rejection.

ЦИТИРОВАНО В
  1. Leemans Jaklien C., Stokman Geurt, Claessen Nike, Rouschop Kasper M., Teske Gwendoline J.D., Kirschning Carsten J., Akira Shizuo, van der Poll Tom, Weening Jan J., Florquin Sandrine, Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney, Journal of Clinical Investigation, 115, 10, 2005. Crossref

  2. Ribes Sandra, Ebert Sandra, Regen Tommy, Czesnik Dirk, Scheffel Jörg, Zeug Andre, Bunkowski Stephanie, Eiffert Helmut, Hanisch Uwe-Karsten, Hammerschmidt Sven, Nau Roland, Fibronectin stimulatesEscherichia coliphagocytosis by microglial cells, Glia, 2009. Crossref

  3. Aravalli Rajagopal N., Peterson Phillip K., Lokensgard James R., Toll-like Receptors in Defense and Damage of the Central Nervous System, Journal of Neuroimmune Pharmacology, 2, 4, 2007. Crossref

  4. Nigrovic Peter A., Lee David M., Synovial mast cells: role in acute and chronic arthritis, Immunological Reviews, 217, 1, 2007. Crossref

  5. Rolls Asya, Shechter Ravid, London Anat, Ziv Yaniv, Ronen Ayal, Levy Rinat, Schwartz Michal, Toll-like receptors modulate adult hippocampal neurogenesis, Nature Cell Biology, 9, 9, 2007. Crossref

  6. Lee Joo Y, Zhao Ling, Hwang Daniel H, Modulation of pattern recognition receptor-mediated inflammation and risk of chronic diseases by dietary fatty acids, Nutrition Reviews, 68, 1, 2010. Crossref

  7. Methe Heiko, Zimmer Edgar, Grimm Cornelia, Nabauer Michael, Koglin Joerg, Evidence for a Role of Toll-Like Receptor 4 in Development of Chronic Allograft Rejection after Cardiac Transplantation, Transplantation, 78, 9, 2004. Crossref

  8. Smith Kelly D, Alpers Charles E, Pathogenic mechanisms in membranoproliferative glomerulonephritis, Current Opinion in Nephrology & Hypertension, 14, 4, 2005. Crossref

  9. Morran Michael P., Omenn Gilbert S., Pietropaolo Massimo, Immunology and genetics of type 1 diabetes, Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine, 75, 4, 2008. Crossref

  10. Eady E. Anne, Viewpoint 3, Experimental Dermatology, 14, 2, 2005. Crossref

  11. Alexander S P H, Mathie A, Peters J A, Toll-like family, British Journal of Pharmacology, 2006. Crossref

  12. Young Steven L., Lyddon Terri D., Jorgenson Rebecca L., Misfeldt Michael L., Expression of Toll-like Receptors in Human Endometrial Epithelial Cells and Cell Lines, American Journal of Reproductive Immunology, 52, 1, 2004. Crossref

  13. Rock Kenneth L., Shen Lianjun, Cross-presentation: underlying mechanisms and role in immune surveillance, Immunological Reviews, 207, 1, 2005. Crossref

  14. Shechter Ravid, Ronen Ayal, Rolls Asya, London Anat, Bakalash Sharon, Young Michael J., Schwartz Michal, Toll-like receptor 4 restricts retinal progenitor cell proliferation, Journal of Cell Biology, 183, 3, 2008. Crossref

  15. Rifkin Ian R., Leadbetter Elizabeth A., Busconi Liliana, Viglianti Gregory, Marshak-Rothstein Ann, Toll-like receptors, endogenous ligands, and systemic autoimmune disease, Immunological Reviews, 204, 1, 2005. Crossref

  16. Morran Michael P, McInerney Marcia F, Pietropaolo Massimo, Innate and adaptive autoimmunity in type 1 diabetes, Pediatric Diabetes, 9, 2, 2008. Crossref

  17. Zhang Zheng, Li Weijie, Sun Dongdong, Zhao Li, Zhang Rongqing, Wang Yabin, Zhou Xuan, Wang Haichang, Cao Feng, Toll-like receptor 4 signaling in dysfunction of cardiac microvascular endothelial cells under hypoxia/reoxygenation, Inflammation Research, 60, 1, 2011. Crossref

  18. Benhamou Ygal, Favre Julie, Musette Philippe, Renet Sylvanie, Thuillez Christian, Richard Vincent, Tamion Fabienne, Toll-like receptors 4 contribute to endothelial injury and inflammation in hemorrhagic shock in mice, Critical Care Medicine, 37, 5, 2009. Crossref

  19. Hammond Caitlin, Shi Yonghong, Mena Jenny, Tomic Jelena, Cervi David, He Liwei, Millar Amanda E., DeBenedette Mark, Schuh Andre C., Baryza Jeremy L., Wender Paul A., Radvanyi Laszlo, Spaner David E., Effect of Serum and Antioxidants on the Immunogenicity of Protein Kinase C-Activated Chronic Lymphocytic Leukemia Cells, Journal of Immunotherapy, 28, 1, 2005. Crossref

  20. Mevorach Dror, The role of death-associated molecular patterns in the pathogenesis of systemic lupus erythematosus, Rheumatic Disease Clinics of North America, 30, 3, 2004. Crossref

  21. Lee Jun K., Hwang Daniel H., Lee Joo Y., Toll-like receptors in the pathogenesis of inflammatory diseases, Journal of Organ Dysfunction, 5, 2, 2009. Crossref

  22. Aboussahoud Wedad, Aflatoonian Reza, Bruce Chris, Elliott Sarah, Ward Jon, Newton Sue, Hombach-Klonisch Sabine, Klonisch Thomas, Fazeli Alireza, Expression and function of Toll-like receptors in human endometrial epithelial cell lines, Journal of Reproductive Immunology, 84, 1, 2010. Crossref

  23. Bonventre Joseph V., Yang Li, Cellular pathophysiology of ischemic acute kidney injury, Journal of Clinical Investigation, 121, 11, 2011. Crossref

  24. Wang Zhong, Zuo Gang, Shi Xiao-Yong, Zhang Jian, Fang Qi, Chen Gang, Progesterone Administration Modulates Cortical TLR4/NF-κB Signaling Pathway after Subarachnoid Hemorrhage in Male Rats, Mediators of Inflammation, 2011, 2011. Crossref

  25. Basith Shaherin, Manavalan Balachandran, Lee Gwang, Kim Sang Geon, Choi Sangdun, Toll-like receptor modulators: a patent review (2006 – 2010), Expert Opinion on Therapeutic Patents, 21, 6, 2011. Crossref

  26. Stassen Frank R., Vega-Córdova Xavier, Vliegen Inge, Bruggeman Cathrien A., Immune activation following cytomegalovirus infection: More important than direct viral effects in cardiovascular disease?, Journal of Clinical Virology, 35, 3, 2006. Crossref

  27. Zhou Meng-liang, Wu Wei, Ding Ya-suo, Zhang Fei-fan, Hang Chun-hua, Wang Han-dong, Cheng Hui-lin, Yin Hong-xia, Shi Ji-xin, Expression of Toll-like receptor 4 in the basilar artery after experimental subarachnoid hemorrhage in rabbits: A preliminary study, Brain Research, 1173, 2007. Crossref

  28. Wang Zhi-Yong, He Jun-Xian, Brassinosteroid signal transduction – choices of signals and receptors, Trends in Plant Science, 9, 2, 2004. Crossref

  29. Teng Weiyu, Wang Lishu, Xue Weishuang, Guan Chao, Activation of TLR4-Mediated NFB Signaling in Hemorrhagic Brain in Rats, Mediators of Inflammation, 2009, 2009. Crossref

  30. Layton A. M., Disorders of the Sebaceous Glands, in Rook's Textbook of Dermatology, 2010. Crossref

  31. Kiener Hans P., Nigrovic Peter A., Lee David M., Mast Cells, in Rheumatoid Arthritis, 2009. Crossref

  32. Dessing Mark C., Bemelman Frederike J., Claessen Nike, ten Berge Ineke J. M., Florquin Sandrine, Leemans Jaklien C., Intragraft Toll-like receptor profiling in acute renal allograft rejection, Nephrology Dialysis Transplantation, 25, 12, 2010. Crossref

  33. Chen Gang, Zhang Shiming, Shi Jixin, Ai Jinglu, Qi Meng, Hang Chunhua, Simvastatin reduces secondary brain injury caused by cortical contusion in rats: Possible involvement of TLR4/NF-κB pathway, Experimental Neurology, 216, 2, 2009. Crossref

  34. Nasu Kaei, Narahara Hisashi, Pattern Recognition via the Toll-Like Receptor System in the Human Female Genital Tract, Mediators of Inflammation, 2010, 2010. Crossref

  35. Finley David S, Pouliot Frederic, Chin Arnold I, Shuch Brian, Pantuck Alan J, Belldegrun Arie S, Dekernion Jean B, Immunological therapy in urological malignancy: Novel combination strategies, International Journal of Urology, 18, 2, 2011. Crossref

  36. Johnson Geoffrey B., Brunn Gregory J., Samstein Benjamin, Platt Jeffrey L., New insight into the pathogenesis of sepsis and the sepsis syndrome, Surgery, 137, 4, 2005. Crossref

  37. Kim Hun Sik, Han Myoung Sook, Chung Kun Wook, Kim Sunshin, Kim Eunshil, Kim Myoung Joo, Jang Eunkyeong, Lee Hyun Ah, Youn Jeehee, Akira Shizuo, Lee Myung-Shik, Toll-like Receptor 2 Senses β-Cell Death and Contributes to the Initiation of Autoimmune Diabetes, Immunity, 27, 2, 2007. Crossref

  38. Brunn Gregory J., Platt Jeffrey L., The etiology of sepsis: turned inside out, Trends in Molecular Medicine, 12, 1, 2006. Crossref

  39. Liu Guangwei, Wu You, Gong Shouliang, Zhao Yong, Toll-like receptors and graft rejection, Transplant Immunology, 16, 1, 2006. Crossref

  40. Gunaratnam Lakshman, Bonventre Joseph V., Pathophysiology of Acute Kidney Injury, in Primer on Kidney Diseases, 2009. Crossref

  41. Li Min, Song Lujun, Gao Xiaodong, Chang Wenju, Qin Xinyu, Toll-like receptor 4 on islet β cells senses expression changes in high-mobility group box 1 and contributes to the initiation of type 1 diabetes, Experimental & Molecular Medicine, 44, 4, 2012. Crossref

  42. Anisimova N. Yu., Dolzhikova Yu. I., Davankov V. A., Pastukhov A. V., Miljaeva S. I., Senatov F. S., Kiselevsky M. V., Prospects for the application of biporous sorbents based on hypercrosslinked styrene polymers for the prevention and treatment of systemic purulent-septic complications, Nanotechnologies in Russia, 7, 5-6, 2012. Crossref

  43. Hotchkiss Richard S., Strasser Andreas, McDunn Jonathan E., Swanson Paul E., Cell Death, New England Journal of Medicine, 361, 16, 2009. Crossref

  44. Sakata Hiromi, Yonekawa Motoki, Kawamura Akio, Blood purification therapy for sepsis, Transfusion and Apheresis Science, 35, 3, 2006. Crossref

  45. Matsui Tomohiro, Tasaki Moe, Yoshioka Takahiro, Motoki Yukari, Tsuneoka Hidehiro, Nojima Junzo, Temperature- and time-dependent changes in TLR2-activated microglial NF-κB activity and concentrations of inflammatory and anti-inflammatory factors, Intensive Care Medicine, 38, 8, 2012. Crossref

  46. Kim Jee In, Kim In Kyeom, Probing Regulatory Proteins for Vascular Contraction by Deoxyribonucleic Acid Microarray, Korean Circulation Journal, 42, 7, 2012. Crossref

  47. Mao Shan-Shan, Hua Rong, Zhao Xiao-Ping, Qin Xia, Sun Zhen-Quan, Zhang Yang, Wu Yu-Qing, Jia Meng-Xing, Cao Jun-Li, Zhang Yong-Mei, Exogenous Administration of PACAP Alleviates Traumatic Brain Injury in Rats through a Mechanism Involving the TLR4/MyD88/NF-κB Pathway, Journal of Neurotrauma, 29, 10, 2012. Crossref

  48. O'Neill Stephen, Ross James A, Wigmore Stephen J, Harrison Ewen M, The role of heat shock protein 90 in modulating ischemia–reperfusion injury in the kidney, Expert Opinion on Investigational Drugs, 21, 10, 2012. Crossref

  49. MARÍN-GARCÍA JOSÉ, Molecular Basis of Lipoprotein Disorders, Atherogenesis, and Thrombosis, in Post-Genomic Cardiology, 2007. Crossref

  50. Pérez-de Puig Isabel, Miró Francesc, Salas-Perdomo Angélica, Bonfill-Teixidor Ester, Ferrer-Ferrer Maura, Márquez-Kisinousky Leonardo, Planas Anna M, IL-10 Deficiency Exacerbates the Brain Inflammatory Response to Permanent Ischemia without Preventing Resolution of the Lesion, Journal of Cerebral Blood Flow & Metabolism, 33, 12, 2013. Crossref

  51. Waikar Sushrut S., Gunaratnam Lakshman, Bonventre Joseph V., Pathophysiology of Acute Kidney Injury, in National Kidney Foundation Primer on Kidney Diseases, 2014. Crossref

  52. Matsui Tomohiro, Motoki Yukari, Yoshida Yusuke, Hypothermia Reduces Toll-Like Receptor 3-Activated Microglial Interferon-βand Nitric Oxide Production, Mediators of Inflammation, 2013, 2013. Crossref

  53. Coniglio Salvatore J., Segall Jeffrey E., Review: Molecular mechanism of microglia stimulated glioblastoma invasion, Matrix Biology, 32, 7-8, 2013. Crossref

  54. Zhou Mian, Wang Christie M., Yang Weng-Lang, Wang Ping, Microglial CD14 activated by iNOS contributes to neuroinflammation in cerebral ischemia, Brain Research, 1506, 2013. Crossref

  55. Dai Xiao-jing, Li Na, Yu Le, Chen Zi-yang, Hua Rong, Qin Xia, Zhang Yong-Mei, Activation of BV2 microglia by lipopolysaccharide triggers an inflammatory reaction in PC12 cell apoptosis through a toll-like receptor 4-dependent pathway, Cell Stress and Chaperones, 20, 2, 2015. Crossref

  56. Lu Hongyan, Liu Xingmiao, Zhang Nan, Zhu Xiaodong, Liang Hao, Sun Li, Cheng Yan, Neuroprotective Effects of Brain-Derived Neurotrophic Factor and Noggin-Modified Bone Mesenchymal Stem Cells in Focal Cerebral Ischemia in Rats, Journal of Stroke and Cerebrovascular Diseases, 25, 2, 2016. Crossref

  57. Axelsson Jakob, Norrman Gustav, Malmström Anders, Weström Björn, Andersson Roland, Initiation of acute pancreatitis by heparan sulphate in the rat, Scandinavian Journal of Gastroenterology, 43, 4, 2008. Crossref

  58. Zandieh Z., Ashrafi M., Jameie B., Amanpour S., Mosaffa N., Salman Yazdi R., Pacey A., Aflatoonian R., Evaluation of immunological interaction between spermatozoa and fallopian tube epithelial cells, Andrologia, 47, 10, 2015. Crossref

  59. Leemans Jaklien C., Butter Loes M., Pulskens Wilco P. C., Teske Gwendoline J. D., Claessen Nike, van der Poll Tom, Florquin Sandrine, Tailleux Ludovic, The Role of Toll-Like Receptor 2 in Inflammation and Fibrosis during Progressive Renal Injury, PLoS ONE, 4, 5, 2009. Crossref

  60. Vasileiou Ioanna, Kostopanagiotou Georgia, Katsargyris Athanasios, Klonaris Chris, Perrea Despina, Theocharis Stamatios, Toll-like receptors: a novel target for therapeutic intervention in intestinal and hepatic ischemia–reperfusion injury?, Expert Opinion on Therapeutic Targets, 14, 8, 2010. Crossref

  61. Liu Xiao-dong, Zhang Fubo, Shan Hu, Wang Shu-bai, Chen Pu-Yan, mRNA expression in different developmental stages of the chicken bursa of Fabricius, Poultry Science, 95, 8, 2016. Crossref

  62. Ni Hongbin, Jin Wei, Zhu Tiansheng, Wang Jing, Yuan Baoyu, Jiang Jian, Liang Weibang, Ma Zhengliang, Curcumin modulates TLR4/NF-κB inflammatory signaling pathway following traumatic spinal cord injury in rats, The Journal of Spinal Cord Medicine, 38, 2, 2015. Crossref

  63. Zhu Wei, Li Jie, Liu Yigang, Xie Kun, Wang Le, Fang Jianmin, Mesencephalic astrocyte-derived neurotrophic factor attenuates inflammatory responses in lipopolysaccharide-induced neural stem cells by regulating NF-κB and phosphorylation of p38-MAPKs pathways, Immunopharmacology and Immunotoxicology, 38, 3, 2016. Crossref

  64. Kawakita Fumihiro, Fujimoto Masashi, Liu Lei, Nakano Fumi, Nakatsuka Yoshinari, Suzuki Hidenori, Effects of Toll-Like Receptor 4 Antagonists Against Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage in Mice, Molecular Neurobiology, 54, 8, 2017. Crossref

  65. Kaul David, Habbel Piet, Derkow Katja, Krüger Christina, Franzoni Eleonora, Wulczyn F. Gregory, Bereswill Stefan, Nitsch Robert, Schott Eckart, Veh Rüdiger, Naumann Thomas, Lehnardt Seija, Alexopoulou Lena, Expression of Toll-Like Receptors in the Developing Brain, PLoS ONE, 7, 5, 2012. Crossref

  66. Kindzelskii Andrei L. , Elner Victor M. , Elner Susan G. , Yang Dongli , Hughes Bret A. , Petty Howard R. , Toll-Like Receptor 4 (TLR4) of Retinal Pigment Epithelial Cells Participates in Transmembrane Signaling in Response to Photoreceptor Outer Segments , Journal of General Physiology, 124, 2, 2004. Crossref

  67. Mohammad Mohammad K., Morran Michael, Slotterbeck Brandon, Leaman Douglas W., Sun Yaping, Grafenstein Hermann von, Hong Soon-Cheol, McInerney Marcia F., Dysregulated Toll-like receptor expression and signaling in bone marrow-derived macrophages at the onset of diabetes in the non-obese diabetic mouse, International Immunology, 18, 7, 2006. Crossref

  68. Pulskens Wilco P., Teske Gwendoline J., Butter Loes M., Roelofs Joris J., van der Poll Tom, Florquin Sandrine, Leemans Jaklien C., Zimmer Jacques, Toll-Like Receptor-4 Coordinates the Innate Immune Response of the Kidney to Renal Ischemia/Reperfusion Injury, PLoS ONE, 3, 10, 2008. Crossref

  69. Sprong Tom, Ley Peter van der, Abdollahi-Roodsaz Shahla, Joosten Leo, Meer Jos van der, Netea Mihai, Deuren Marcel van, Neisseria meningitidislipid A mutant LPSs function as LPS antagonists in humans by inhibiting TLR 4-dependent cytokine production, Innate Immunity, 17, 6, 2011. Crossref

  70. Tang Amy H., Brunn Gregory J., Cascalho Marilia, Platt Jeffrey L., Pivotal Advance: Endogenous pathway to SIRS, sepsis, and related conditions, Journal of Leukocyte Biology, 82, 2, 2007. Crossref

  71. Barsness Katherine A., Arcaroli John, Harken Alden H., Abraham Edward, Banerjee Anirban, Reznikov Leonid, McIntyre Robert C., Hemorrhage-induced acute lung injury is TLR-4 dependent, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 287, 3, 2004. Crossref

  72. Kanagasundaram Nigel Suren, Pathophysiology of ischaemic acute kidney injury, Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 52, 2, 2015. Crossref

  73. He Zili, Zhou Yulong, Lin Li, Wang Qingqing, Khor Sinan, Mao Yuqin, Li Jiawei, Zhen Zengming, Chen Jian, Gao Zhenzhen, Wu Fenzan, Zhang Xie, Zhang Hongyu, Xu Hua-Zi, Wang Zhouguang, Xiao Jian, Dl-3-n-butylphthalide attenuates acute inflammatory activation in rats with spinal cord injury by inhibiting microglial TLR4/NF-κB signalling, Journal of Cellular and Molecular Medicine, 21, 11, 2017. Crossref

  74. Moeckel Gilbert W., Pathologic Perspectives on Acute Tubular Injury Assessment in the Kidney Biopsy, Seminars in Nephrology, 38, 1, 2018. Crossref

  75. van Bergenhenegouwen Jeroen, Plantinga Theo S., Joosten Leo A. B., Netea Mihai G., Folkerts Gert, Kraneveld Aletta D., Garssen Johan, Vos Arjan P., TLR2 & Co: a critical analysis of the complex interactions between TLR2 and coreceptors, Journal of Leukocyte Biology, 94, 5, 2013. Crossref

  76. Pollara Justin, Edwards R. Whitney, Lin Liwen, Bendersky Victoria A., Brennan Todd V., Circulating mitochondria in deceased organ donors are associated with immune activation and early allograft dysfunction, JCI Insight, 3, 15, 2018. Crossref

  77. Cappelletti Monica, Della Bella Silvia, Ferrazzi Enrico, Mavilio Domenico, Divanovic Senad, Inflammation and preterm birth, Journal of Leukocyte Biology, 99, 1, 2016. Crossref

  78. Chang Yi-Chung, Kao Wei-Chen, Wang Wei-Ya, Wang Wan-Yi, Yang Ruey-Bing, Peck Konan, Identification and characterization of oligonucleotides that inhibit Toll‐like receptor 2‐associated immune responses, The FASEB Journal, 23, 9, 2009. Crossref

  79. Farrar Conrad A., Keogh Brian, McCormack William, O'Shaughnessy Aisling, Parker Andrew, Reilly Mary, Sacks Steven H., Inhibition of TLR2 promotes graft function in a murine model of renal transplant ischemia‐reperfusion injury, The FASEB Journal, 26, 2, 2012. Crossref

  80. Zan Jie, Zhang Hao, Lu Min-yi, Beng Hui-min, Zhong Kai-lun, Sun Xiao-ou, Tan Wen, Isosteviol sodium injection improves outcomes by modulating TLRs/NF-κB-dependent inflammatory responses following experimental traumatic brain injury in rats, NeuroReport, 29, 10, 2018. Crossref

  81. Marín-García José, Goldenthal Michael J., Moe Gordon W., Atherosclerosis, Hypertension and Aging, in Aging and the Heart, 2008. Crossref

  82. Keene C. D., Cimino P. J., Breyer R. M., Montine K. S., Montine T. J., E Prostanoid Receptors in Brain Physiology and Disease, in Handbook of Neurochemistry and Molecular Neurobiology, 2008. Crossref

  83. Fort Madeline M., Mozaffarian Afsaneh, Stöver Axel G., Correia Jean da Silva, Johnson David A., Crane R. Thomas, Ulevitch Richard J., Persing David H., Bielefeldt-Ohmann Helle, Probst Peter, Jeffery Eric, Fling Steven P., Hershberg Robert M., A Synthetic TLR4 Antagonist Has Anti-Inflammatory Effects in Two Murine Models of Inflammatory Bowel Disease, The Journal of Immunology, 174, 10, 2005. Crossref

  84. Alpers Charles E., Wietecha Tomasz A., Hudkins Kelly L., Experimental Models of Mixed Cryoglobulinemia, in HCV Infection and Cryoglobulinemia, 2012. Crossref

  85. Nakamura Morihiko, Notsu Kaori, Nakagawa Mai, Heat shock protein 60 negatively regulates the biological functions of ubiquitin-like protein MNSFβ in macrophages, Molecular and Cellular Biochemistry, 456, 1-2, 2019. Crossref

  86. Fu Yuyang, Xie Chun, Chen Jianlin, Zhu Jiankun, Zhou Hui, Thomas James, Zhou Xin J., Mohan Chandra, Innate Stimuli Accentuate End-Organ Damage by Nephrotoxic Antibodies via Fc Receptor and TLR Stimulation and IL-1/TNF-α Production, The Journal of Immunology, 176, 1, 2006. Crossref

  87. Pulskens Wilco P., Rampanelli Elena, Teske Gwendoline J., Butter Loes M., Claessen Nike, Luirink Ilse K., van der Poll Tom, Florquin Sandrine, Leemans Jaklien C., TLR4 Promotes Fibrosis but Attenuates Tubular Damage in Progressive Renal Injury, Journal of the American Society of Nephrology, 21, 8, 2010. Crossref

  88. Van der Meer P, Lipsic E, Henning RH, Boddeus K, van der Velden J, Voors AA, van Veldhuisen DJ, van Gilst WH, Schoemaker RG, Heart Failure after Myocardial Infarction—Benefit beyond Hemoglobin from Erythropoietin, Journal of the American Society of Nephrology, 16, 12, 2005. Crossref

  89. Bonventre Joseph V., Mechanisms of Acute Kidney Injury and Repair, in Management of Acute Kidney Problems, 2010. Crossref

  90. Kono Hajime, Karmarkar Dipti, Iwakura Yoichiro, Rock Kenneth L., Identification of the Cellular Sensor That Stimulates the Inflammatory Response to Sterile Cell Death, The Journal of Immunology, 184, 8, 2010. Crossref

  91. Johnson Geoffrey B., Riggs B. Lawrence, Platt Jeffrey L., A genetic basis for the “Adonis” phenotype of low adiposity and strong bones, The FASEB Journal, 18, 11, 2004. Crossref

  92. Maezawa Izumi, Nivison Mary, Montine Kathleen S., Maeda Nobuyo, Montine Thomas J., Neurotoxicity from innate immune response is greatest with targeted replacement of ε4 allele of apolipoprotein E gene and is mediated by microglial p38MAPK, The FASEB Journal, 20, 6, 2006. Crossref

  93. Gromova E.G., Extracorporeal detoxification in cancer patients, Anesteziologiya i reanimatologiya, 5, 2020. Crossref

  94. Tammaro A, Florquin S, Brok M, Claessen N, Butter L M, Teske G J D, de Boer O J, Vogl T, Leemans J C, Dessing M C, S100A8/A9 promotes parenchymal damage and renal fibrosis in obstructive nephropathy, Clinical and Experimental Immunology, 193, 3, 2018. Crossref

  95. Maezawa Izumi, Maeda Nobuyo, Montine Thomas J, Montine Kathleen S, Apolipoprotein E-specific innate immune response in astrocytes from targeted replacement mice, Journal of Neuroinflammation, 3, 1, 2006. Crossref

  96. Parish Christopher R, Innate Immune Mechanisms: Nonself Recognition, in eLS, 2005. Crossref

  97. Weile C, Josefsen K, Buschard K, Glucose activation of islets of Langerhans up-regulates Toll-like receptor 5: possible mechanism of protection, Clinical and Experimental Immunology, 166, 2, 2011. Crossref

  98. Quah Ben JC, Parish Christopher R, Innate Immune Mechanisms: Nonself Recognition, in eLS, 2015. Crossref

  99. Qingfeng Wang , Yongfeng Tao , Monosialoganglioside (GM1) Attenuates Spinal Cord Injury-Induced Inflammation by Inhibiting TLR4/NF-κB Pathway, Neurochemical Journal, 15, 2, 2021. Crossref

  100. Quah Ben JC, Parish Christopher R, Innate Immune Mechanisms: Nonself Recognition, in eLS, 2010. Crossref

  101. Maezawa Izumi, Zaja-Milatovic Snjezana, Milatovic Dejan, Stephen Christina, Sokal Izabela, Maeda Nobuyo, Montine Thomas J, Montine Kathleen S, Apolipoprotein E isoform-dependent dendritic recovery of hippocampal neurons following activation of innate immunity, Journal of Neuroinflammation, 3, 1, 2006. Crossref

  102. Ullah Faheem, Gamage Rashmi, Sen Monokesh K., Gyengesi Erika, The Effects of Modified Curcumin Preparations on Glial Morphology in Aging and Neuroinflammation, Neurochemical Research, 47, 4, 2022. Crossref

  103. Zhang Ruili, Guo Rong, Liu Qing, Li Guangxing, Sun Bin, Huang Xiaodan, Selenium Deficiency via the TLR4/TRIF/NF-κB Signaling Pathway Leading to Inflammatory Injury in Chicken Spleen, Biological Trace Element Research, 199, 2, 2021. Crossref

  104. Kulkarni Priya, Harsulkar Abhay, Märtson Anne-Grete, Suutre Siim, Märtson Aare, Koks Sulev, Mast Cells Differentiated in Synovial Fluid and Resident in Osteophytes Exalt the Inflammatory Pathology of Osteoarthritis, International Journal of Molecular Sciences, 23, 1, 2022. Crossref

  105. Farinelli L., Aquili A., Mattioli-Belmonte M., Manzotti S., D’Angelo F., Ciccullo C., Gigante A., Synovial mast cells from knee and hip osteoarthritis: histological study and clinical correlations, Journal of Experimental Orthopaedics, 9, 1, 2022. Crossref

  106. Zhu Xudong, Zong Guijuan, Zhu Liu, Jiang Yuchen, Ma Ke, Zhang Hanwen, Zhang Yan, Bai Hui, Yang Qing, Ben Jingjing, Li Xiaoyu, Xu Yong, Chen Qi, Deletion of Class A Scavenger Receptor Deteriorates Obesity-Induced Insulin Resistance in Adipose Tissue, Diabetes, 63, 2, 2014. Crossref

  107. Stoll Lynn L., Denning Gerene M., Weintraub Neal L., Potential Role of Endotoxin as a Proinflammatory Mediator of Atherosclerosis, Arteriosclerosis, Thrombosis, and Vascular Biology, 24, 12, 2004. Crossref

  108. Sommerfeldt Nora, Beckhove Philipp, Ge Yingzi, Schütz Florian, Choi Carmen, Bucur Mariana, Domschke Christoph, Sohn Christof, Schneeweis Andreas, Rom Joachim, Pollmann Dirk, Leucht Dagmar, Vlodavsky Israel, Schirrmacher Volker, Heparanase: A New Metastasis-Associated Antigen Recognized in Breast Cancer Patients by Spontaneously Induced Memory T Lymphocytes, Cancer Research, 66, 15, 2006. Crossref

  109. Johnson Barbara J., Le Thuy T.T., Dobbin Caroline A., Banovic Tatjana, Howard Christopher B., Flores Flor de Maria Leon, Vanags Daina, Naylor Dean J., Hill Geoffrey R., Suhrbier Andreas, Heat Shock Protein 10 Inhibits Lipopolysaccharide-induced Inflammatory Mediator Production, Journal of Biological Chemistry, 280, 6, 2005. Crossref

  110. Bonventre Joseph V., Molecular and Genetic Aspects of Ischemic Acute Kidney Injury, in Molecular and Genetic Basis of Renal Disease, 2008. Crossref

  111. Win-Shwe Tin-Tin, Kunugita Naoki, Yoshida Yasuhiro, Fujimaki Hidekazu, Role of hippocampal TLR4 in neurotoxicity in mice following toluene exposure, Neurotoxicology and Teratology, 33, 5, 2011. Crossref

  112. Zhu Minghua, Barbas Andrew S., Lin Liwen, Scheuermann Uwe, Bishawi Muath, Brennan Todd V., Mitochondria Released by Apoptotic Cell Death Initiate Innate Immune Responses, ImmunoHorizons, 2, 11, 2018. Crossref

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