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Critical Reviews™ in Immunology
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ISSN Печать: 1040-8401
ISSN Онлайн: 2162-6472

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Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v23.i12.60
20 pages

Signal Transduction via MHC Class I Molecules in Endothelial and Smooth Muscle Cells

Elaine F. Reed
UCLA Immunogenetics Center, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095

Краткое описание

MHC class I molecules have long been recognized for their ability to stimulate intracellular signals in T and B lymphocytes. More recently, it has become clear that MHC class I molecules can also initiate intracellular signals in endothelial and smooth muscle cells, which synergize with growth factor receptors to elicit cell proliferation. This review describes our current knowledge of class I–mediated signaling pathways in human endothelial and smooth muscle cells. The role of the class I signaling pathway in modulating cell growth and the clinical significance of this pathway in chronic allograft rejection are discussed.

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