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Critical Reviews™ in Immunology
Импакт фактор: 1.352 5-летний Импакт фактор: 3.347 SJR: 0.657 SNIP: 0.55 CiteScore™: 2.19

ISSN Печать: 1040-8401
ISSN Онлайн: 2162-6472

Выпуски:
Том 39, 2019 Том 38, 2018 Том 37, 2017 Том 36, 2016 Том 35, 2015 Том 34, 2014 Том 33, 2013 Том 32, 2012 Том 31, 2011 Том 30, 2010 Том 29, 2009 Том 28, 2008 Том 27, 2007 Том 26, 2006 Том 25, 2005 Том 24, 2004 Том 23, 2003 Том 22, 2002 Том 21, 2001 Том 20, 2000 Том 19, 1999 Том 18, 1998 Том 17, 1997 Том 16, 1996 Том 15, 1995 Том 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v15.i2.30
pages 155-165

The Repertoire of T-Cell Receptors in Systemic Sclerosis

Vladimir V. Yurovsky
University of Maryland School of Medicine, Baltimore, MD 21201

Краткое описание

Certain T cell subsets are increased in systemic sclerosis patients, particularly Vδ1+ γδ T cells in the blood and lungs and CD8+ αβ T cells in the lungs. The repertoires of T cell antigen receptor (TCR) Vδl, Vα, and Vβ gene families were examined by two methods of analysis. First, the relative abundance of Vα and Vβ gene transcripts was determined in the blood and bronchoalveolar fluid of the patients. Second, the diversity of the junctional regions in TCR Vδl transcripts and in different Vα and Vβ gene families was analyzed. Limited Vδ-Cδ junctional region lengths were observed in the patients compared with controls. This was confirmed by sequence analysis of Vδ1-Cδ junctional regions after subcloning amplified products in a bacterial vector. Evidence for selection of the Vδl+ T cells in the tissues of patients came from the findings that the same Vδ1-Cδ junctional sequences persisted in an individual patient over time and that identical junctional sequences were isolated from multiple sites. A restricted diversity of the junctional region lengths was also detected in a number of Vα and Vβ gene families, particularly within bronchoalveolar CD8+ T cell subset. These data suggest that the oligoclonal expansion of the corresponding αβ and γδ T cells is antigen-driven and may be important in the pathogenesis of systemic sclerosis.


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