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Critical Reviews™ in Immunology
Импакт фактор: 1.352 5-летний Импакт фактор: 3.347 SJR: 1.022 SNIP: 0.55 CiteScore™: 2.19

ISSN Печать: 1040-8401
ISSN Онлайн: 2162-6472

Выпуски:
Том 39, 2019 Том 38, 2018 Том 37, 2017 Том 36, 2016 Том 35, 2015 Том 34, 2014 Том 33, 2013 Том 32, 2012 Том 31, 2011 Том 30, 2010 Том 29, 2009 Том 28, 2008 Том 27, 2007 Том 26, 2006 Том 25, 2005 Том 24, 2004 Том 23, 2003 Том 22, 2002 Том 21, 2001 Том 20, 2000 Том 19, 1999 Том 18, 1998 Том 17, 1997 Том 16, 1996 Том 15, 1995 Том 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v15.i2.40
pages 167-200

Lymphocyte Adhesion to Endothelium

Umberto Dianzani
Laboratorio di Immunologia, Dipartimento di Scienze Mediche, Universita di Torino, sede di Novara, Novara, Italy
Fabio Malavasi
lstituto di Biologia e Genetica, Universita di Ancona, Ancona, Italy

Краткое описание

The different homing and recirculation behaviors of lymphocytes depend on expression of specific adhesion receptors by lymphocytes and endothelial cells. Expression of these receptors is finely regulated according to cell type, functional state, and anatomical location, and builds up a complex network of interactions that simultaneously involve several of these receptors working as "traffic signals" or "postcodes" for lymphocyte migration and homing. There are five main families of adhesion molecules: immunoglobulin superfamily, integrins, selectins, cadherins, and mucin-like molecules. Together with these "classified" receptors, other molecules, such as CD44 and CD38, have been shown to be involved in lymphocyte migration and homing. Leukocytes have evolved a intracellular system that allows them to maintain these receptors in an inactive state during transit in the bloodstream and extracellular fluids and activate them only when proper specific stimuli are delivered. This activity has been called "inside-out" signaling. Most receptor/ligand systems regulating lymphocyte migration are not selectively dedicated to this function. They are involved in lymphocyte interaction with several cell types and play a key role in both the afferent and efferent branches of immune responses by mediating lymphocyte interaction with APC and target cells. They not only "passively" anchor lymphocytes to these cells but also exert an active "outside-in" signaling function that modulates the cell response to activation stimuli. In this review, we briefly describe the major features of these molecules, survey what is known about their role in lymphocyte/endothelium interactions both in vitro and in vivo, and discuss their possible therapeutical application.

Ключевые слова: integrin, selectin, addressin, cadherin, CD38, CD44.

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