Выходит 6 номеров в год
ISSN Печать: 1040-8401
ISSN Онлайн: 2162-6472
IF:
1.3
5-Year IF:
2.6
Eigenfactor:
0.00079
JCI:
0.24
SJR:
0.429
SNIP:
0.287
CiteScore™::
2.7
H-Index:
81
Indexed in
The Role of Invariant NKT Cells in Allogeneic Hematopoietic Stem Cell Transplantation
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Краткое описание
Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative procedure for a number of hematological malignancies including leukemia and lymphoma. However, the anti-leukemia (graft-versus-leukemia, GVL) effect mediated by T cells transferred to the host with the allograft is often negated by the graft-versus-host (GVH) reaction imparted by the same cells. Acute graft-versus-host disease (aGVHD), an allogeneic reaction triggered in response to minor and major histocompatibility antigen disparities between donor and recipient, remains the main source of morbidity and mortality in T-cell−replete allogeneic HSCT. Here we review the biological properties, the pre-clinical work, and the recent clinical observations suggesting that invariant natural killer (iNK) T cells, a CD1d-restricted subset of immunoregulatory T cells, are important regulators of GVH and GVL reactions. Further, we outline strategies for manipulating iNKT cells to translate their therapeutic promise into clinical benefit in the context of allogeneic HSCT.
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TRUJILLO-OCAMPO ABEL, CHO HYUN-WOO, HERRMANN AMANDA C., RUIZ-VAZQUEZ WILFREDO, THORNTON ANDREW B., HE HONG, LI DAN, QAZILBASH MARIAM A., MA QING, PORCELLI STEVEN A., SHPALL ELIZABETH J., MOLLDREM JEFFREY, IM JIN S., Rapid ex vivo expansion of highly enriched human invariant natural killer T cells via single antigenic stimulation for cell therapy to prevent graft-versus-host disease, Cytotherapy, 20, 8, 2018. Crossref
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Papoutselis Menelaos, Spanoudakis Emmanouil, Navigating the Role of CD1d/Invariant Natural Killer T-cell/Glycolipid Immune Axis in Multiple Myeloma Evolution: Therapeutic Implications, Clinical Lymphoma Myeloma and Leukemia, 20, 6, 2020. Crossref
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Novel Cell Therapies and Manipulations: Ready for Prime-Time?, in Hematopoietic Cell Transplants, 2017. Crossref
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