Выходит 6 номеров в год
ISSN Печать: 1040-8401
ISSN Онлайн: 2162-6472
Indexed in
Posttranslational Regulation of Cell-Surface Colony-Stimulating Factor-1
Краткое описание
Colony-stimulating factor-1 (CSF-1) plays a central role in the survival, proliferation, differentiation, and function of monocytes and macrophages. CSF-1 is synthesized as both a soluble and a membrane-spanning growth factor. The membrane-spanning isoform is biologically active, but it can also be proteolytically cleaved to generate a soluble growth factor. A recent study revealed that the TNF-α-converting enzyme is involved in this activity, and, moreover, that membrane-spanning CSF-1 undergoes internalization. These findings may have important implications for the posttranslational regulation and the functions of cell-surface CSF-1.
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Kos O., Hughson R.L., Hart D.A., Clément G., Frings-Meuthen P., Linnarsson D., Paloski W.H., Rittweger J., Wuyts F., Zange J., Gorczynski R.M., Elevated serum soluble CD200 and CD200R as surrogate markers of bone loss under bed rest conditions, Bone, 60, 2014. Crossref
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Horiuchi Keisuke, Morioka Hideo, Takaishi Hironari, Akiyama Haruhiko, Blobel Carl P., Toyama Yoshiaki, Ectodomain Shedding of FLT3 Ligand Is Mediated by TNF-α Converting Enzyme, The Journal of Immunology, 182, 12, 2009. Crossref
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Hakozaki Akihiro, Yoda Masaki, Tohmonda Takahide, Furukawa Mitsuru, Hikata Tomohiro, Uchikawa Shinichi, Takaishi Hironari, Matsumoto Morio, Chiba Kazuhiro, Horiuchi Keisuke, Toyama Yoshiaki, Receptor Activator of NF-κB (RANK) Ligand Induces Ectodomain Shedding of RANK in Murine RAW264.7 Macrophages, The Journal of Immunology, 184, 5, 2010. Crossref
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Grubišić Vladimir, McClain Jonathon L., Fried David E., Grants Iveta, Rajasekhar Pradeep, Csizmadia Eva, Ajijola Olujimi A., Watson Ralph E., Poole Daniel P., Robson Simon C., Christofi Fievos L., Gulbransen Brian D., Enteric Glia Modulate Macrophage Phenotype and Visceral Sensitivity following Inflammation, Cell Reports, 32, 10, 2020. Crossref