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ISSN Печать: 1040-8401
ISSN Онлайн: 2162-6472
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Induction of Dendritic Cells (DC) by Flt3 Ligand (FL) Promotes the Generation of Tumor-Specific Immune Responses In Vivo
Краткое описание
Daily treatment of mice with human Flt3 ligand (FL) induces the production of large numbers of ÌÍÑ-class II+, CDllc+, DEC205+ dendritic cells (DC) in both lymphoid and nonlymphoid tissues. Because DC play a pivotal role in the induction of immune responses, we evaluated the effects of FL in the augmentation of anti-tumor immune responses in vivo. Treatment with daily subcutaneous injections of FL not only caused complete regression of tumors in a significant proportion of mice challenged with a syngeneic methylcholanthrene-induced fibrosarcoma, but also caused a significant decrease in the tumor growth rate in the remaining mice. The effects of FL were both dose and schedule dependent, induced regression of tumors established as much as 7 days prior to beginning cytokine treatment, and was mediated by both T-cell-mediated and non-T-cell-mediated mechanisms. Histopathologic evaluation of tumors during and after systemic treatment with FL revealed a dense infiltration of mononuclear and myeloid precursor cells into both the tumor and tissue surrounding the tumor that generally correlated with the degree of regression and resolved after rejection of the tumor. Collectively, the data suggest that FL may be an important cytokine in the generation of effective anti-tumor immune responses in vivo and the treatment of cancer in situ.
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Disis Mary L, Schiffman Kathy, Salazar Lupe G, Almand Bond, Knutson Keith L, , 21, 2003. Crossref
-
Shurin Michael R., Yurkovetsky Zoya R., Tourkova Irina L., Balkir Levent, Shurin Galina V., Inhibition of CD40 expression and CD40-mediated dendritic cell function by tumor-derived IL-10, International Journal of Cancer, 101, 1, 2002. Crossref
-
Chen Wangxue, Rains Natalie, Young David, Stubbs Richard S, Dendritic cell‐based cancer immunotherapy: Potential for treatment of colorectal cancer?, Journal of Gastroenterology and Hepatology, 15, 7, 2000. Crossref
-
Byrne Scott N, Halliday Gary M, Dendritic cells: Making progress with tumour regression?, Immunology and Cell Biology, 80, 6, 2002. Crossref
-
Talmadge James E., Biotherapeutics, in Biotechnology and Safety Assessment, 2003. Crossref
-
Tourkova Irina L., Yamabe Kazuo, Chatta Gurkamal, Shurin Galina V., Shurin Michael R., NK Cells Mediate Flt3 Ligand-Induced Protection of Dendritic Cell Precursors In Vivo from the Inhibition by Prostate Carcinoma in the Murine Bone Marrow Metastasis Model, Journal of Immunotherapy, 26, 6, 2003. Crossref
-
Jones Lori A, Salgaller Michael L, Therapeutic potential of dendritic-based vaccines, Expert Opinion on Investigational Drugs, 8, 7, 1999. Crossref
-
Le Poole I. Caroline, ElMasri Wafic M., Denman Cecele J., Kroll Tara M., Bommiasamy Hemamalini, Lyons Eiben Gretchen, Kast W. Martin, Langerhans cells and dendritic cells are cytotoxic towards HPV16 E6 and E7 expressing target cells, Cancer Immunology, Immunotherapy, 57, 6, 2008. Crossref
-
Kreitman Robert J, IBC’s International Conference on Novel Therapeutic Proteins for Oncology (Drug Discovery and Development), Expert Opinion on Investigational Drugs, 7, 4, 1998. Crossref
-
Shurin Galina V, Chatta Gurkamal S, Tourkova Irina L, Zorina Tatiana D, Esche Clemens, Shurin Michael R, Regulation of dendritic cell expansion in aged athymic nude mice by FLT3 ligand, Experimental Gerontology, 39, 3, 2004. Crossref
-
Baek Kyoung Min, Ko Sung-Youl, Lee Mira, Lee Joong-Seok, Kim Jae-Ouk, Ko Hyun-Jeong, Lee Jae-Woo, Lee Sang-Hoon, Cho Sang-Nae, Kang Chang-Yuil, Comparative analysis of effects of cytokine gene adjuvants on DNA vaccination against Mycobacterium tuberculosis heat shock protein 65, Vaccine, 21, 25-26, 2003. Crossref
-
Dallal Ramsey M, Lotze Michael T, The dendritic cell and human cancer vaccines, Current Opinion in Immunology, 12, 5, 2000. Crossref
-
Smyth Mark J., Thia Kevin Y. T., Street Shayna E.A., Cretney Erika, Trapani Joseph A., Taniguchi Masaru, Kawano Tetsu, Pelikan Sonja B., Crowe Nadine Y., Godfrey Dale I., Differential Tumor Surveillance by Natural Killer (Nk) and Nkt Cells, Journal of Experimental Medicine, 191, 4, 2000. Crossref
-
Venanzi F.M., Barucca A., Havas K., Capitani M., Provinciali M., Scotti S., Concetti A., Co-expression of Flt-3 ligand gene ablates tumor immunity elicited by HER-2/neu DNA vaccine in transgenic mice, Vaccine, 28, 22, 2010. Crossref
-
Aloysius M.M., Takhar A., Robins A., Eremin O., Dendritic cell biology, dysfunction and immunotherapy in gastrointestinal cancers, The Surgeon, 4, 4, 2006. Crossref
-
Pisarev Vladimir M, Parajuli Prahlad, Mosley R.Lee, Sublet Jennifer, Kelsey Linda, Sarin Prem S, Zimmerman Daniel H, Winship M.Douglas, Talmadge James E, Flt3 ligand enhances the immunogenicity of a gag-based HIV-1 vaccine, International Journal of Immunopharmacology, 22, 11, 2000. Crossref
-
Morse Michael A., Immunotherapy for Resected Pulmonary Metastases, Thoracic Surgery Clinics, 26, 1, 2016. Crossref
-
Kwon Taeg Kyu, Park Jong-Wook, Intramuscular co-injection of naked DNA encoding HBV core antigen and Flt3 ligand suppresses anti-HBc antibody response, Immunology Letters, 81, 3, 2002. Crossref
-
Xing Feiyue, Wang Jiongkun, Fang Zhiyuan, Hu Mingqian, Yu Yu, Chen Guoliang, Liu Jing, Nano-characterization of Jagged-1-educated dendritic cells, Open Life Sciences, 6, 6, 2011. Crossref
-
Evans Thomas G, Hasan Muhammad, Galibert Laurent, Caron Dania, The use of Flt3 ligand as an adjuvant for hepatitis B vaccination of healthy adults, Vaccine, 21, 3-4, 2002. Crossref
-
Brown Janice M, Weissman Irving L, Shizuru Judith A, Immunity to infections following hematopoietic cell transplantation, Current Opinion in Immunology, 13, 4, 2001. Crossref
-
Rini Brian, Recent clinical development of dendritic cell-based immunotherapy for prostate cancer, Expert Opinion on Biological Therapy, 4, 11, 2004. Crossref
-
Kim Eugene M., Sivanandham Muthukumaran, Stavropoulos Christos I., Wallack Marc K., Adjuvant Effect of a Flt3 Ligand (FL) Gene-Transduced Xenogeneic Cell Line in a Murine Colon Cancer Model, Journal of Surgical Research, 108, 1, 2002. Crossref
-
Panoskaltsis Nicki, Belanger Todd J, Liesveld Jane L, Abboud Camille N, Optimal cytokine stimulation for the enhanced generation of leukemic dendritic cells in short-term culture, Leukemia Research, 26, 2, 2002. Crossref
-
Lee Mosley R, Parajuli Prahlad, Pisarev Vladimir, Chavez Jennifer, Meeks Amy, Steffel Amy, Leutzinger Cheryl, Talmadge James E, Flt3 ligand augmentation of T cell mitogenesis and expansion of type 1 effector/memory T cells, International Immunopharmacology, 2, 7, 2002. Crossref
-
D'Amico Angela , Wu Li , The Early Progenitors of Mouse Dendritic Cells and Plasmacytoid Predendritic Cells Are within the Bone Marrow Hemopoietic Precursors Expressing Flt3 , Journal of Experimental Medicine, 198, 2, 2003. Crossref
-
Ali Sumia, Curtin James F., Zirger Jeffrey M., Xiong Weidong, King Gwendalyn D., Barcia Carlos, Liu Chunyan, Puntel Mariana, Goverdhana Shyam, Lowenstein Pedro R., Castro Maria G., Inflammatory and Anti-glioma Effects of an Adenovirus Expressing Human Soluble Fms-like Tyrosine Kinase 3 Ligand (hsFlt3L): Treatment with hsFlt3L Inhibits Intracranial Glioma Progression, Molecular Therapy, 10, 6, 2004. Crossref
-
Favre-Felix Nathalie, Martin Monique, Maraskovsky Eugene, Fromentin Annie, Moutet Monique, Solary Eric, Martin Fran�ois, Bonnotte Bernard, Flt3 ligand lessens the growth of tumors obtained after colon cancer cell injection in rats but does not restore tumor-suppressed dendritic cell function, International Journal of Cancer, 86, 6, 2000. Crossref
-
Cui Yan, Kelleher Erin, Straley Erin, Fuchs Ephraim, Gorski Kevin, Levitsky Hyam, Borrello Ivan, Civin Curt I, Schoenberger Stephen P, Cheng Linzhao, Pardoll Drew M, Whartenby Katharine A, Immunotherapy of established tumors using bone marrow transplantation with antigen gene–modified hematopoietic stem cells, Nature Medicine, 9, 7, 2003. Crossref
-
Weigel Brenda J., Nath Narender, Taylor Patricia A., Panoskaltsis-Mortari Angela, Chen Wei, Krieg Arthur M., Brasel Kenneth, Blazar Bruce R., Comparative analysis of murine marrow–derived dendritic cells generated by Flt3L or GM-CSF/IL-4 and matured with immune stimulatory agents on the in vivo induction of antileukemia responses, Blood, 100, 12, 2002. Crossref
-
Xing Feiyue, Wang Jiongkun, Hu Mingqian, Yu Yu, Chen Guoliang, Liu Jing, Comparison of immature and mature bone marrow-derived dendritic cells by atomic force microscopy, Nanoscale Research Letters, 6, 1, 2011. Crossref
-
Pawlowska Anna B., Hashino Satoshi, McKenna Hilary, Weigel Brenda J., Taylor Patricia A., Blazar Bruce R., In vitro tumor-pulsed or in vivo Flt3 ligand–generated dendritic cells provide protection against acute myelogenous leukemia in nontransplanted or syngeneic bone marrow–transplanted mice, Blood, 97, 5, 2001. Crossref
-
O'Keeffe Meredith, Hochrein Hubertus, Vremec David, Pooley Joanne, Evans Robert, Woulfe Susan, Shortman Ken, Effects of administration of progenipoietin 1, Flt-3 ligand, granulocyte colony-stimulating factor, and pegylated granulocyte-macrophage colony-stimulating factor on dendritic cell subsets in mice, Blood, 99, 6, 2002. Crossref
-
Disis Mary L., Rinn Kristine, Knutson Keith L., Davis Donna, Caron Dania, dela Rosa Corazon, Schiffman Kathy, Flt3 ligand as a vaccine adjuvant in association with HER-2/neu peptide-based vaccines in patients with HER-2/neu–overexpressing cancers, Blood, 99, 8, 2002. Crossref
-
Alaniz Robert C., Sandall Sharsti, Thomas Elaine K., Wilson Christopher B., Increased Dendritic Cell Numbers Impair Protective Immunity to Intracellular Bacteria Despite Augmenting Antigen-Specific CD8+T Lymphocyte Responses, The Journal of Immunology, 172, 6, 2004. Crossref
-
Wang Jing-Bo, Huang Xue, Li Fu-Rong, Impaired dendritic cell functions in lung cancer: a review of recent advances and future perspectives, Cancer Communications, 39, 1, 2019. Crossref
-
Ho Ling-Jun, Wang Jaang-Jiun, Shaio Men-Fang, Kao Chuan-Liang, Chang Deh-Ming, Han Shou-Wha, Lai Jenn-Haung, Infection of Human Dendritic Cells by Dengue Virus Causes Cell Maturation and Cytokine Production, The Journal of Immunology, 166, 3, 2001. Crossref
-
Moore Anne C., Kong Wing-pui, Chakrabarti Bimal K., Nabel Gary J., Effects of Antigen and Genetic Adjuvants on Immune Responses to Human Immunodeficiency Virus DNA Vaccines in Mice, Journal of Virology, 76, 1, 2002. Crossref
-
Whartenby Katharine A., Calabresi Peter A., McCadden Erin, Nguyen Bao, Kardian David, Wang Tianhong, Mosse Claudio, Pardoll Drew M., Small Donald, Inhibition of FLT3 signaling targets DCs to ameliorate autoimmune disease, Proceedings of the National Academy of Sciences, 102, 46, 2005. Crossref
-
Morse Michael A., Nair Smita, Fernandez-Casal Monica, Deng Yuping, St Peter Michelle, Williams Rhonda, Hobeika Amy, Mosca Paul, Clay Tim, Cumming R. Ian, Fisher Eva, Clavien Pierre, Proia Alan D., Niedzwiecki Donna, Caron Dania, Lyerly H. Kim, Preoperative Mobilization of Circulating Dendritic Cells by Flt3 Ligand Administration to Patients With Metastatic Colon Cancer, Journal of Clinical Oncology, 18, 23, 2000. Crossref
-
Parajuli Prahlad, Mosley R.Lee, Pisarev Vladimir, Chavez Jennifer, Ulrich Amy, Varney Michelle, Singh Rakesh K, Talmadge James E, Flt3 ligand and granulocyte-macrophage colony-stimulating factor preferentially expand and stimulate different dendritic and T-cell subsets, Experimental Hematology, 29, 10, 2001. Crossref
-
Péron Jean-Marie, Esche Clemens, Subbotin Vladimir M., Maliszewski Charles, Lotze Michael T., Shurin Michael R., FLT3-Ligand Administration Inhibits Liver Metastases: Role of NK Cells, The Journal of Immunology, 161, 11, 1998. Crossref
-
Williams Noelle Sevilir, Klem Jennifer, Puzanov Igor J., Sivakumar P. V., Bennett Michael, Kumar Vinay, Differentiation of NK1.1+, Ly49+ NK Cells from flt3+ Multipotent Marrow Progenitor Cells, The Journal of Immunology, 163, 5, 1999. Crossref