Доступ предоставлен для: Guest
Critical Reviews™ in Immunology

Выходит 6 номеров в год

ISSN Печать: 1040-8401

ISSN Онлайн: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

Viral Infection and Cancer: The NF-κB/Snail/RKIP Loop Regulates Target Cell Sensitivity to Apoptosis by Cytotoxic Lymphocytes

Том 30, Выпуск 1, 2010, pp. 31-46
DOI: 10.1615/CritRevImmunol.v30.i1.20
Get accessGet access

Краткое описание

The anti-viral/tumor cytotoxic T cells exert their killing mechanisms by the granzyme-perforin and death ligand-induced necrosis and apoptosis. These death ligands include TNF-α (tumor-necrosis factor-alpha), FasL (Fas ligand), and TRAIL (TNF-related apoptosis-inducing ligand). However, many target cells resist killing by the cytotoxic T cells. Tis review discusses potential novel underlying mechanisms of resistance and implicate an NF-κB (nuclear factor kappa beta)-Snail (SNAI-1)-RKIP (Raf-1 kinase inhibitor protein) circuitry in resistant targets. TRAIL-mediated killing of a tumor cell line is used as an example to illustrate the circuitry. Tumor cells resistant to TRAIL-mediated apoptosis can be sensitized by NF-κB inhibitors. Inhibition of NF-κB results in the induction of RKIP. RKIP overexpression sensitizes the cells to TRAIL. RKIP is induced following inhibition of the RKIP transcription repressor, Snail, downstream of NF-κB. Snail siRNA reverses resistance to TRAIL. Because RKIP negatively regulates NF-κB, we propose that the resistant cell phenotype could be maintained through Snail-mediated RKIP suppression which supports the constitutive NF-κB activation. This review introduces a new paradigm, namely, that the cytotoxic T-cell response to viral infection and/or cancer may be compromised by the target cells expressing the resistant NF-κB-Snail-RKIP phenotype. Alternative therapeutic interventions, such as various inhibitors, NF-κB inhibitors, and siRNAs, are presented.

ЦИТИРОВАНО В
  1. Escara-Wilke June, Yeung Kam, Keller Evan T., Raf kinase inhibitor protein (RKIP) in cancer, Cancer and Metastasis Reviews, 31, 3-4, 2012. Crossref

  2. Li Si Wei, Wang Hua, Liu Mei lian, Zhang Hai Bo, Xiang Yan Qun, Lv Xing, Xia Wei Xiong, Zeng Mu Sheng, Mai Hai Qiang, Hong Ming Huang, Guo Xiang, Positive effect of high RKIP expression on reduced distant metastasis by chemotherapy when combined with radiotherapy in locoregionally advanced nasopharyngeal carcinoma: a prospective study, Medical Oncology, 30, 1, 2013. Crossref

  3. Sancho-Martínez Sandra M., Prieto-García Laura, Prieto Marta, López-Novoa José M., López-Hernández Francisco J., Subcellular targets of cisplatin cytotoxicity: An integrated view, Pharmacology & Therapeutics, 136, 1, 2012. Crossref

  4. Chen Tun-Chieh, Hsu Ya-Ling, Tsai Yu-Chieh, Chang Yu-Wei, Kuo Po-Lin, Chen Yen-Hsu, Gemifloxacin inhibits migration and invasion and induces mesenchymal–epithelial transition in human breast adenocarcinoma cells, Journal of Molecular Medicine, 92, 1, 2014. Crossref

  5. Su Baowei, Cengizeroglu Arzu, Farkasova Katarina, Viola Joana R., Anton Martina, Ellwart Joachim W., Haase Rudolf, Wagner Ernst, Ogris Manfred, Systemic TNFα Gene Therapy Synergizes With Liposomal Doxorubicine in the Treatment of Metastatic Cancer, Molecular Therapy, 21, 2, 2013. Crossref

  6. al-Mulla Fahd, Bitar Milad S., Taqi Zainab, Rath Oliver, Kolch Walter, RAF kinase inhibitory protein (RKIP) modulates cell cycle kinetics and motility, Mol. BioSyst., 7, 3, 2011. Crossref

  7. Gao Chengcheng, Pang Liqun, Ren Chengcheng, Ma Tianheng, Prognostic Value of Raf Kinase Inhibitor Protein in Esophageal Squamous Cell Carcinoma, Pathology & Oncology Research, 18, 2, 2012. Crossref

  8. WAN ZHAOJUN, PAN HUAZHENG, LIU SHIHAI, ZHU JINGJUAN, QI WEIWEI, FU KAI, ZHAO TENG, LIANG JUN, Downregulation of SNAIL sensitizes hepatocellular carcinoma cells to TRAIL-induced apoptosis by regulating the NF-κB pathway, Oncology Reports, 33, 3, 2015. Crossref

  9. Martinho Olga, Granja Sara, Jaraquemada Teresa, Caeiro Cláudia, Miranda-Gonçalves Vera, Honavar Mrinalini, Costa Paulo, Damasceno Margarida, Rosner Marsha R., Lopes José M., Reis Rui M., Jones Chris, Downregulation of RKIP Is Associated with Poor Outcome and Malignant Progression in Gliomas, PLoS ONE, 7, 1, 2012. Crossref

  10. Chen I.-Chieh, Huang Hsin-Hsiu, Chen Pei-Fen, Chiang Hung-Che, Sirtuin 3 Protects against Urban Particulate Matter-Induced Autophagy in Human Bronchial Epithelial Cells, Toxicological Sciences, 152, 1, 2016. Crossref

  11. Shvartsur Anna, Givechian Kevin B., Garban Hermes, Bonavida Benjamin, Overexpression of RKIP and its cross-talk with several regulatory gene products in multiple myeloma, Journal of Experimental & Clinical Cancer Research, 36, 1, 2017. Crossref

  12. Mongre Raj Kumar, Sodhi Simrinder Singh, Ghosh Mrinmoy, Kim Jeong Hyun, Kim Nameun, Sharma Neelesh, Jeong Dong Kee, A New Paradigm to Mitigate Osteosarcoma by Regulation of MicroRNAs and Suppression of the NF-κB Signaling Cascade, Development & Reproduciton, 18, 4, 2014. Crossref

  13. Alkatout Ibrahim, Hübner Friederike, Wenners Antonia, Hedderich Jürgen, Wiedermann Meike, Sánchez Cristina, Röcken Christoph, Mathiak Micaela, Maass Nicolai, Klapper Wolfram, In situ localization of tumor cells associated with the epithelial-mesenchymal transition marker Snail and the prognostic impact of lymphocytes in the tumor microenvironment in invasive ductal breast cancer, Experimental and Molecular Pathology, 102, 2, 2017. Crossref

  14. Al-Mulla Fahd, Bitar Milad S., Feng Jingwei, Park Sungdae, Yeung Kam C., Lee Terence, A New Model for Raf Kinase Inhibitory Protein Induced Chemotherapeutic Resistance, PLoS ONE, 7, 1, 2012. Crossref

  15. Zaravinos Apostolos, Bonavida Benjamin, Chatzaki Ekaterini, Baritaki Stavroula, RKIP: A Key Regulator in Tumor Metastasis Initiation and Resistance to Apoptosis: Therapeutic Targeting and Impact, Cancers, 10, 9, 2018. Crossref

  16. Abd Allah Marwa Said, Rashad Heba Mohammed, Significance of Beclin-1, hypoxia-inducible factor-1α, and nuclear factor-κB/p65 expression in colorectal carcinoma, Egyptian Journal of Pathology, 37, 2, 2017. Crossref

  17. Bonavida Benjamin, Sensitization of Immune-Resistant Tumor Cells to CTL-Mediated Apoptosis via Interference at the Dysregulated NF-κB/Snail/YY1/PI3K/RKIP/PTEN Resistant Loop, in Resistance of Cancer Cells to CTL-Mediated Immunotherapy, 7, 2015. Crossref

  18. Özenver Nadire, Efferth Thomas, Therapeutic targeting of SNAIL, RKIP, and YY1 in tumor metastasis and drug resistance, in Prognostic and Therapeutic Applications of RKIP in Cancer, 2020. Crossref

  19. Wang Yuhao, Bonavida Benjamin, Pleiotropic activities of RKIP in cancer: Role in survival, EMT, chemo-immuno-resistance, and autophagy, in Prognostic and Therapeutic Applications of RKIP in Cancer, 2020. Crossref

  20. Wang Siyun, Ma Haiqing, Yan Yan, Chen Yu, Fu Sirui, Wang Junjiang, Wang Ying, Chen Hao, Liu Jianhua, cMET promotes metastasis and epithelial‐mesenchymal transition in colorectal carcinoma by repressing RKIP, Journal of Cellular Physiology, 236, 5, 2021. Crossref

  21. Hsu Ya-Ling, Chen Chung-Yi, Lin In-Pin, Tsai Eing-Mei, Kuo Po-Lin, Hou Ming-Feng, 4-Shogaol, an Active Constituent of Dietary Ginger, Inhibits Metastasis of MDA-MB-231 Human Breast Adenocarcinoma Cells by Decreasing the Repression of NF-κB/Snail on RKIP, Journal of Agricultural and Food Chemistry, 60, 3, 2012. Crossref

  22. Touboul Roni, Baritaki Stavroula, Zaravinos Apostolos, Bonavida Benjamin, RKIP Pleiotropic Activities in Cancer and Inflammatory Diseases: Role in Immunity, Cancers, 13, 24, 2021. Crossref

  23. Ruan Tao, Sun Yuling, Zhang Jingting, Sun Jing, Liu Wei, Prinz Richard A., Peng Daxin, Liu Xiufan, Xu Xiulong, H5N1 infection impairs the alveolar epithelial barrier through intercellular junction proteins via Itch-mediated proteasomal degradation, Communications Biology, 5, 1, 2022. Crossref

  24. Kikuchi Hidehiko, Kuribayashi Futoshi, Imajoh-Ohmi Shinobu, Down-regulation of Fas-mediated apoptosis by plasma transglutaminase factor XIII that catalyzes fetal-specific cross-link of the Fas molecule, Biochemical and Biophysical Research Communications, 443, 1, 2014. Crossref

  25. Al-Mulla Fahd, Bitar Milad S., Al-Maghrebi May, Behbehani Abdulla I., Al-Ali Waleed, Rath Oliver, Doyle Brendan, Tan Kit Yee, Pitt Andrew, Kolch Walter, Raf Kinase Inhibitor Protein RKIP Enhances Signaling by Glycogen Synthase Kinase-3β, Cancer Research, 71, 4, 2011. Crossref

Статьи, принятые к публикации

Identification of a novel five-gene prognostic model for laryngeal cancer associated with mitophagy using integrated bioinformatics analysis and experimental verification Dong Song, Lun Dong, Mei Wang, Xiaoping Gao Function of steroid receptor coactivators (SRCs) in T cells and cancers: Implications for cancer immunotherapy Wencan Zhang, Xu Cao, Hongmin Wu, Xiancai Zhong, Yun Shi, Zuoming Sun Electroacupuncture Alleviates Ischemic Stroke by Activating the mTOR/SREBP1 Pathway Jiawang Lang, Jianchang Luo, Luodan Wang, Wenbin Xu, Jie Jia, Zhipeng Zhao, Boxu Lang KIAA1429 induces the m6A modification of LINC01106 to enhance the malignancy of lung adenocarcinoma cell via JAK/STAT3 pathway Di Xu, Ziming Wang, Fajiu Li Effect of p-estrogen receptor at serine on its function and breast growth Yuan Liang, Junhui Qin, Tiancheng Ma, Tong Yang, Zhenyu Ke, Ruian Wang Mechanistic Insights into Tanshinone IIA in the Amelioration of Post-Thyroidectomy Hypoparathyroidism Xiaoyu Qian, Lin Li, Liang Chen, Chao Shen, Jian Tang MiRNA let-7d-5p alleviates inflammatory responses by targeting Map3k1 and inactivating ERK/p38 MAPK signaling in microglia Fan Fang, Cheng Chen Role of Natural Killer Cells as Cell-Based Immunotherapy in Oral Tumor Eradication and Differentiation Both In Vivo and In Vitro Kawaljit Kaur, Anahid Jewett The Current and Future States of Natural Killer Cell-Based Immunotherapy in Hepatocellular Carcinoma Tu Nguyen, Po-Chun Chen, Janet Pham, Kawaljit Kaur, Steven Raman, Anahid Jewett, Jason Chiang Phillygenin alleviated arthritis through the inhibition of NLRP3 inflammasome and Ferroptosis by AMPK Jianghui Wang, Shufang Ni, Kai Zheng, Yan Zhao, peihong zhang, Hong Chang The value of systemic immune-inflammation index and T cell subsets in the severity and prognosis of sepsis Hao Zhou Efficacy and Nuances of Precision Molecular Engineering for Hodgkin's Disease to a Gene Therapeutic Approach Muhammad Imran Qadir, Bilal Ahmed, Nadir Hussain Serum interleukin 6 and ferritin levels are the independent risk factors for pneumonia in elderly patients Hao Yuan, Jing Tian, Lu Wen Exploration of diagnostic markers associated with inflammation in chronic kidney disease (CKD) based on WGCNA and machine learning Qianjia Wu, Yang Yang, Chongze Lin Clinical significance of serum CTRP3 level in the prediction of cardiac dysfunction and intestinal mucosal barrier dysfunction in patients with severe acute pancreatitis Qiang Shao, Lin Sun The protective effect and mechanism of mild hypothermia on pig lung injury after cardiopulmonary resuscitation Jinlin Ren, Fangfang Zhu, Dongdong Sang, Mulin Cong, Shujuan Jiang Exploring mechanism of Zilongjin in treating lung adenocarcinoma based on network pharmacology combined with experimental verification Kang Zhang, Xiaoqun Chen Gastric Cancer Immune Subtypes and Prognostic Modeling: Insights from Aging-Related Genes Analysis Jian Shen, Minzhe Li Effects of different doses of dexmedetomidine on the prevention of postoperative sleep disturbance and serum neurotransmitter level in patients under general anesthesia Huifei Lu, Fei He, Ying Huang, Zhongliang Wei Identification of key ubiquitination-related genes and their associated with immune infiltration in osteoarthritis based on mRNA-miRNA network Dalu Yuan, Hailiang Shen, Lina Bai, Menglin Li, Qiujie Ye Diagnostic and Prognostic value of peripheral neutrophil CD64 index in elderly patients with community-acquired pneumonia Yan Li, Jing Zhang, Suhang Wang, Jie Cao Identification of Metabolism-Related Prognostic Biomarkers and Immune Features of Head and Neck Squamous Cell Carcinoma Rongjin Zhou, Junguo Wang Downregulation of miR-503-5p promotes the development of pancreatic cancer via targeting cyclin E2 Fei Li, Ying-pei Ling, Pan Wang, Shi-cheng Gu, Hao Jiang, Jie Zhu
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции Цены и условия подписки Begell House Контакты Language English 中文 Русский Português German French Spain