Выходит 6 номеров в год
ISSN Печать: 1040-8401
ISSN Онлайн: 2162-6472
Indexed in
The Regulation of Endotoxin Tolerance and its Impact on Macrophage Activation
Краткое описание
Endotoxin tolerance in macrophages is a key regulatory mechanism to limit the innate immune response to infection or injury. Long considered a state of unresponsiveness to Toll-like receptor activation, tolerance is now recognized as a state of altered responsiveness to infection or injury. Endotoxin tolerance leads to a shift away from a pro-inflammatory response toward a response with key anti-inflammatory and pro-resolution features. Advances in our understanding of Toll-like receptor function have identified a number of molecular mechanisms that promote tolerance, but how these are integrated to achieve gene-specific regulation is an important outstanding question. The potential to harness the mechanisms of endotoxin tolerance to promote the resolution of chronic inflammation warrants the continued investigation of this fundamental feature of innate immunity. This review focuses on the endotoxin tolerant state, our understanding of the underlying molecular mechanisms, and the clinical significance of endotoxin tolerance.
-
Kapellos Theodore S., Taylor Lewis, Lee Heyne, Cowley Sally A., James William S., Iqbal Asif J., Greaves David R., A novel real time imaging platform to quantify macrophage phagocytosis, Biochemical Pharmacology, 116, 2016. Crossref
-
Strnad Pavel, Tacke Frank, Koch Alexander, Trautwein Christian, Liver — guardian, modifier and target of sepsis, Nature Reviews Gastroenterology & Hepatology, 14, 1, 2017. Crossref
-
Liu Yang, Xie Xin, Xia Li-Ping, Lv Hong, Lou Fan, Ren Yan, He Zhi-Yi, Luo Xiao-Guang, Peripheral immune tolerance alleviates the intracranial lipopolysaccharide injection-induced neuroinflammation and protects the dopaminergic neurons from neuroinflammation-related neurotoxicity, Journal of Neuroinflammation, 14, 1, 2017. Crossref
-
Mitchell Jennifer P., Carmody Ruaidhrí J., NF-κB and the Transcriptional Control of Inflammation, in Transcriptional Gene Regulation in Health and Disease, 335, 2018. Crossref
-
Pinheiro da Silva Fabiano, Machado Marcel Cerqueira César, Septic Shock and the Aging Process: A Molecular Comparison, Frontiers in Immunology, 8, 2017. Crossref
-
Munford Robert S., Endotoxemia-menace, marker, or mistake?, Journal of Leukocyte Biology, 100, 4, 2016. Crossref
-
Kim Sena, Joe Yeonsoo, Park Se-Ung, Jeong Sun Oh, Kim Jin-Kyung, Park Seong Hoon, Pae Hyun-Ock, Surh Young-Joon, Shin Jaekyoon, Chung Hun Taeg, Induction of endoplasmic reticulum stress under endotoxin tolerance increases inflammatory responses and decreasesPseudomonas aeruginosapneumonia, Journal of Leukocyte Biology, 104, 5, 2018. Crossref
-
Rajab Nadia, Rutar Matthew, Laslett Andrew L., Wells Christine A., Designer macrophages: Pitfalls and opportunities for modelling macrophage phenotypes from pluripotent stem cells, Differentiation, 104, 2018. Crossref
-
Peng Xinze, Madany Abdullah M., Jang Jessica C., Valdez Joseph M., Rivas Zuivanna, Burr Abigail C., Grinberg Yelena Y., Nordgren Tara M., Nair Meera G., Cocker David, Carson Monica J., Lo David D., Continuous Inhalation Exposure to Fungal Allergen Particulates Induces Lung Inflammation While Reducing Innate Immune Molecule Expression in the Brainstem, ASN Neuro, 10, 2018. Crossref
-
Butcher Suzanne K., O’Carroll Christine E., Wells Christine A., Carmody Ruaidhrí J., Toll-Like Receptors Drive Specific Patterns of Tolerance and Training on Restimulation of Macrophages, Frontiers in Immunology, 9, 2018. Crossref
-
Varma Rangati, Puri Niti, Dampening of mast cell secondary responses to allergen involves specific signalling and epigenetic changes, Cellular Immunology, 344, 2019. Crossref
-
Iqbal Asif J., Fisher Edward A., Greaves David R., Inflammation-a Critical Appreciation of the Role of Myeloid Cells, in Myeloid Cells in Health and Disease, 2017. Crossref
-
Ling Yunli, Wang Jing, Yu Shuo, Li Wenjie, Lu Hong, The Protective Effect of Low Dose of Lipopolysaccharide Pretreatment on Endotoxin-Induced Uveitis in Rats Is Associated with Downregulation of CSF-1 and Upregulation of LRR-1, Journal of Immunology Research, 2020, 2020. Crossref
-
Liu Xin, Wu Jiaqi, Wang Ning, Xia Lin, Fan Shijun, Lu Yongling, Chen Xiaoli, Shang Shenglan, Yang Yongjun, Huang Qianying, Chen Qian, Zhou Hong, Zheng Jiang, Artesunate reverses LPS tolerance by promoting ULK1-mediated autophagy through interference with the CaMKII-IP3R-CaMKKβ pathway, International Immunopharmacology, 87, 2020. Crossref
-
Yi Zhujun, Wu Yilin, Zhang Wenfeng, Wang Tao, Gong Jianping, Cheng Yao, Miao Chunmu, Activator-Mediated Pyruvate Kinase M2 Activation Contributes to Endotoxin Tolerance by Promoting Mitochondrial Biogenesis, Frontiers in Immunology, 11, 2021. Crossref
-
Munford Robert S., Weiss Jerrold P., Lu Mingfang, Biochemical transformation of bacterial lipopolysaccharides by acyloxyacyl hydrolase reduces host injury and promotes recovery, Journal of Biological Chemistry, 295, 51, 2020. Crossref
-
Martinez-Pomares Luisa, Gordon Siamon, Macrophages and Autoimmunity, in The Autoimmune Diseases, 2020. Crossref
-
Du Yaoyao, Rong Lan, Cong Yuanhua, Shen Lan, Zhang Ning, Wang Bing, Macrophage polarization: an effective approach to targeted therapy of inflammatory bowel disease, Expert Opinion on Therapeutic Targets, 25, 3, 2021. Crossref
-
Li Peizhi, He Kun, Li Jinzheng, Liu Zuojin, Gong Jianping, The role of Kupffer cells in hepatic diseases, Molecular Immunology, 85, 2017. Crossref
-
Gorelik Alexei, Illes Katalin, Nagar Bhushan, Crystal structure of the mammalian lipopolysaccharide detoxifier, Proceedings of the National Academy of Sciences, 115, 5, 2018. Crossref
-
Iqbal Asif J., Fisher Edward A., Greaves David R., Gordon Siamon, Inflammation—a Critical Appreciation of the Role of Myeloid Cells, Microbiology Spectrum, 4, 5, 2016. Crossref
-
Pussinen Pirkko J., Kopra Elisa, Pietiäinen Milla, Lehto Markku, Zaric Svetislav, Paju Susanna, Salminen Aino, Periodontitis and cardiometabolic disorders: The role of lipopolysaccharide and endotoxemia, Periodontology 2000, 89, 1, 2022. Crossref
-
Dembek Anna, Laggai Stephan, Kessler Sonja M., Czepukojc Beate, Simon Yvette, Kiemer Alexandra K., Hoppstädter Jessica, Hepatic interleukin-6 production is maintained during endotoxin tolerance and facilitates lipid accumulation, Immunobiology, 222, 6, 2017. Crossref
-
Jia Li, Lu Jia, Zhou Ya, Tao Yijing, Xu Hualin, Zheng Wen, Zhao Juanjuan, Liang Guiyou, Xu Lin, Tolerogenic dendritic cells induced the enrichment of CD4+Foxp3+ regulatory T cells via TGF-β in mesenteric lymph nodes of murine LPS-induced tolerance model, Clinical Immunology, 197, 2018. Crossref
-
Zhang Jue, Chang Jackie, Beg Mirza Ahmar, Huang Wenxin, Zhao Yiqiong, Dai Wen, Wu Xiaopeng, Cui Weiguo, Pillai Sneha S., Lakhani Hari Vishal, Sodhi Komal, Shapiro Joseph I., Sahoo Daisy, Zheng Ze, Silverstein Roy L., Chen Yiliang, Na/K-ATPase suppresses LPS-induced pro-inflammatory signaling through Lyn, iScience, 25, 9, 2022. Crossref