Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Immunology
Импакт фактор: 1.352 5-летний Импакт фактор: 3.347 SJR: 0.657 SNIP: 0.55 CiteScore™: 2.19

ISSN Печать: 1040-8401
ISSN Онлайн: 2162-6472

Выпуски:
Том 39, 2019 Том 38, 2018 Том 37, 2017 Том 36, 2016 Том 35, 2015 Том 34, 2014 Том 33, 2013 Том 32, 2012 Том 31, 2011 Том 30, 2010 Том 29, 2009 Том 28, 2008 Том 27, 2007 Том 26, 2006 Том 25, 2005 Том 24, 2004 Том 23, 2003 Том 22, 2002 Том 21, 2001 Том 20, 2000 Том 19, 1999 Том 18, 1998 Том 17, 1997 Том 16, 1996 Том 15, 1995 Том 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v21.i1-3.40
18 pages

T-Cell Receptor-Derived Peptides in Immunoregulation and Therapy of Retrovirally Induced Immunosuppression

John J. Marchalonis
Department of Immunobiology, University of Arizona College of Medicine P.O. Box 24-5049 Tucson, AZ 85724
Ian F. Robey
Arizona Cancer Center; Microbiology and Immunology, College of Medicine, University of Arizona, Tucson, AZ 85724
Allen B. Edmundson
Oklahoma Medical Research Foundation, Oklahoma City, OK 73104
R. Tomas Sepulveda
Microbiology and Immunology, College of Medicine, and College of Public Health, University of Arizona, Tucson, AZ 85724
Ronald R. Watson
2College of Public Health, University of Arizona, Tucson, AZ 85724

Краткое описание

Retrovirally infected humans and mice showed progressive acquired immunodeficiency accompanied by the production of elevated levels of autoantibodies directed against T-cell receptor variable-domain epitopes. Epitope mapping analyses indicated that a major determinant recognized was defined by a 16-mer peptide containing the entire CDR1 segment and part of the FR2 region of human Vb8, and that both species showed reactivity to the same sequence. Either prophylactic or therapeutic administration of this peptide to retrovirusinfected C57/BL/6 mice normalized the balance of TH1- and TH2-type helper activity and restored the resistance to infection by the opportunistic parasite Cryptosporidium. Administration of the peptide did not generate significantly increased levels of autoantibody, but had a profound effect on T-cell activity as well as other aspects of inflammation, including NK-cell activity. A 16-mer derived from the Jb sequence showed similar functional effects on T cells from retrovirus-infected mice. Direct binding of the Vb CDR1 peptide to recombinant TCR Va/Vb constructs, as well as to IgM natural autoantibodies, suggests that the cell surface receptor for the peptide is the a/b TCR on T cells and surface IgM in B cells. The Vb CDR1 peptide stimulated division of murine splenocytes in vitro, stimulated the production of the TH1 cytokine IL-2, and synergized with the T-cell mitogen concanavalin A in proliferation and IL-2 production. These studies indicate that administration of peptides derived from T-cell receptor variable domains to animals immunosuppressed as a result of retroviral infection has a profound immunomodulatory effect enhancing overall T-cell functional capacity, particularly with respect to the cytokine production characteristic of TH1-type cells. Our studies are interpreted in the context of other recent investigations of immunomodulatory peptides.


Articles with similar content:

Macrophages Stimulated by Polysaccharide Purified from Agaricus brasiliensis S.Wasser et al. (Agaricomycetideae) Enhance mRNA Expression of Th1 Cytokine Including IL-12 and 18
International Journal of Medicinal Mushrooms, Vol.5, 2003, issue 4
Nobuhide Fujitake, Sachiko Kawakami, Masashi Mizuno
Lymphocytes, Lymphokines, and Silicosis
Journal of Environmental Pathology, Toxicology and Oncology, Vol.20, 2001, issue Suppl.1
Chris E. Holmes, David R. Hemenway, Linda M. Pfeiffer, Gerald S. Davis
Diverse Functional Activity of CD83+ Monocyte-Derived Dendritic Cells and the Implications for Cancer Vaccines
Critical Reviews™ in Immunology, Vol.21, 2001, issue 1-3
Brian J. Czerniecki, Isabelle Bedrosian, Peter A. Cohen, Mark B. Faries, James G. Roros, Shuwen Xu
Features and Functions of gd T Lymphocytes: Focus on Chemokines and Their Receptors
Critical Reviews™ in Immunology, Vol.23, 2003, issue 5-6
Dieter Kabelitz, Daniela Wesch
Biological and Clinical Significance of Human NKRP1A/LLT1 Receptor/Ligand Interactions
Critical Reviews™ in Immunology, Vol.38, 2018, issue 6
Jacek Malejczyk, Agata Bialoszewska