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Critical Reviews™ in Immunology
Импакт фактор: 1.352 5-летний Импакт фактор: 3.347 SJR: 0.657 SNIP: 0.55 CiteScore™: 2.19

ISSN Печать: 1040-8401
ISSN Онлайн: 2162-6472

Выпуски:
Том 39, 2019 Том 38, 2018 Том 37, 2017 Том 36, 2016 Том 35, 2015 Том 34, 2014 Том 33, 2013 Том 32, 2012 Том 31, 2011 Том 30, 2010 Том 29, 2009 Том 28, 2008 Том 27, 2007 Том 26, 2006 Том 25, 2005 Том 24, 2004 Том 23, 2003 Том 22, 2002 Том 21, 2001 Том 20, 2000 Том 19, 1999 Том 18, 1998 Том 17, 1997 Том 16, 1996 Том 15, 1995 Том 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v31.i5.20
pages 379-446

LPS-induced Cytokine Production in Human Monocytes and Macrophages

Manuela Rossol
Department of Internal Medicine, Rheumatology, University of Leipzig, Liebigstr. 21, 04103 Leipzig, Germany
Holger Heine
Section Innate Immunity, Research Center Borstel - Leibnitz Center of Medicine and Life Science, Parkallee 22, 23845 Borstel, Germany
Undine Meusch
Department of Internal Medicine, Rheumatology, University of Leipzig, Liebigstr. 21, 04103 Leipzig, Germany
Dagmar Quandt
Department of Internal Medicine, Rheumatology, University of Leipzig, Liebigstr. 21, 04103 Leipzig, Germany
Carina Klein
Institute of Biology II, Immunobiology, University of Leipzig, Talstr. 33, 04103 Leipzig, Germany
Matthew J. Sweet
The University of Queensland, Institute for Molecular Bioscience and Australian Infectious Diseases Research Centre, Qld, 4072, Australia
Sunna Hauschildt
Institute of Biology II, Immunobiology, University of Leipzig, Talstr. 33, 04103 Leipzig, Germany

Краткое описание

Lipopolysaccharide (LPS) from Gram-negative bacteria is one of the most potent innate immune-activating stimuli known. Here we review the current understanding of LPS effects on human monocyte and macrophage function. We provide an overview of LPS signal transduction with attention given to receptor cooperativity and species differences in LPS responses, as well as the role of tyrosine phosphorylation and lysine acetylation in signalling. We also review LPS-regulated transcription, with emphasis on chromatin remodeling and primary versus secondary transcriptional control mechanisms. Finally, we review the regulation and function of LPS-inducible cytokines produced by human monocytes and macrophages including TNFα, the IL-1 family, IL-6, IL-8, the IL-10 family, the IL-12 family, IL-15 and TGFβ.

Ключевые слова: monocytes, LPS, macrophages, TNF, IL-1, TLR4, cytokines

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