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Critical Reviews™ in Immunology

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ISSN Печать: 1040-8401

ISSN Онлайн: 2162-6472

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Regulation of aicda Expression and AID Activity: Relevance to Somatic Hypermutation and Class Switch DNA Recombination

Том 27, Выпуск 4, 2007, pp. 367-397
DOI: 10.1615/CritRevImmunol.v27.i4.60
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Краткое описание

Expression and activity of activation-induced cytidine deaminase (AID) encoded by the aicda gene are essential for immunoglobulin (Ig) gene somatic hypermutation (SHM) and class switch DNA recombination (CSR). SHM and CSR unfold, in general, in germinal centers and/are central to the maturation of effective antibody responses. AID expression is induced by activated B-cell CD40 signaling, which is critical for the germinal center reaction, and is further enhanced by other stimuli, including interleukin-4 (IL-4) secreted from CD4+ T cells or Toll-like receptor (TLR)-activating bacterial and/or viral molecules. Integration of different intracellular signal transduction pathways, as activated by these stimuli, leads to a dynamic aicda-regulating program, which involves both positively acting trans-factors, such as Pax5, HoxC4, E47, and Irf8, and negative modulators, such as Blimp1 and Id2, to restrict aicda expression primarily to germinal center B cells. The phosphatidylinositol 3-kinase (PI 3-K), which functions downstream of activated B-cell receptor (BCR) signaling, likely plays an important role in triggering the downregulation of aicda expression in postgerminal center B cells and throughout plasmacytoid differentiation. In B cells undergoing SHM and CSR, AID activity, and, possibly, AID targeting to the Ig locus are regulated at a posttranslational level, including AID dimerization/oligomerization, nuclear/cytoplasmic AID translocation, and phosphorylation of the AID Ser38 residue by protein kinase A (PKA). Here, we discuss the role of B-cell activation signals, transcription regulation programs, and posttranslational modifications in controlling aicda expression and AID activity, thereby delineating an integrated model of modulation of SHM and CSR in the germinal center reaction.

ЦИТИРОВАНО В
  1. Mechtcheriakova Diana, Svoboda Martin, Meshcheryakova Anastasia, Jensen-Jarolim Erika, Activation-induced cytidine deaminase (AID) linking immunity, chronic inflammation, and cancer, Cancer Immunology, Immunotherapy, 61, 9, 2012. Crossref

  2. Incorvaia Elisabetta, Sicouri Lara, Petersen-Mahrt Svend K., Schmitz Kerstin-Maike, Hormones and AID: Balancing immunity and autoimmunity, Autoimmunity, 46, 2, 2013. Crossref

  3. Mahdaviani Seyed Alireza, Hirbod-Mobarakeh Armin, Wang Ning, Aghamohammadi Asghar, Hammarström Lennart, Masjedi Mohammad Reza, Pan-Hammarström Qiang, Rezaei Nima, Novel mutation of the activation-induced cytidine deaminase gene in a Tajik family: special review on hyper-immunoglobulin M syndrome, Expert Review of Clinical Immunology, 8, 6, 2012. Crossref

  4. Kim Jin-Hee, Jeong Eui Man, Jeong Young-Joo, Lee Wang Jae, Kang Jae Seung, Kim In-Gyu, Hwang Young-il, Transglutaminase 2 modulates antigen-specific antibody response by suppressing Blimp-1 and AID expression of B cells in mice, Immunology Letters, 147, 1-2, 2012. Crossref

  5. Shih Shyh-Jen, Fass Joseph, Buffalo Vincent, Lin Dawei, Singh Sheetal P., Diaz Manuel O., Vaughan Andrew T., Multiple clonal MLL fusions in a patient receiving CHOP-based chemotherapy, British Journal of Haematology, 159, 1, 2012. Crossref

  6. Mannoor Kaiissar, Xu Yang, Chen Ching, Natural autoantibodies and associated B cells in immunity and autoimmunity, Autoimmunity, 46, 2, 2013. Crossref

  7. Ross A. Catharine, Chen Qiuyan, Ma Yifan, Vitamin A and Retinoic Acid in the Regulation of B-Cell Development and Antibody Production, in Vitamins and the Immune System, 86, 2011. Crossref

  8. Zan Hong, Casali Paolo, Regulation ofAicdaexpression and AID activity, Autoimmunity, 46, 2, 2013. Crossref

  9. Hata Kikumi, Mizuguchi Junichiro, Arginine methylation regulates antibody responses through modulating cell division and isotype switching in B cells, Microbiology and Immunology, 57, 3, 2013. Crossref

  10. Park Seok-Rae, Zan Hong, Pal Zsuzsanna, Zhang Jinsong, Al-Qahtani Ahmed, Pone Egest J, Xu Zhenming, Mai Thach, Casali Paolo, HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation, Nature Immunology, 10, 5, 2009. Crossref

  11. Ouled-Haddou Hakim, Ghamlouch Hussein, Regnier Aline, Trudel Stephanie, Herent Didier, Lefranc Marie-Paule, Marolleau Jean Pierre, Gubler Brigitte, Characterization of a new V gene replacement in the absence of activation-induced cytidine deaminase and its contribution to human B-cell receptor diversity, Immunology, 141, 2, 2014. Crossref

  12. Miyabe Yoshishige, Miyabe Chie, Nanki Toshihiro, Could retinoids be a potential treatment for rheumatic diseases?, Rheumatology International, 35, 1, 2015. Crossref

  13. Kidane Dawit, Chae Wook Jin, Czochor Jennifer, Eckert Kristin A., Glazer Peter M., Bothwell Alfred L. M., Sweasy Joann B., Interplay between DNA repair and inflammation, and the link to cancer, Critical Reviews in Biochemistry and Molecular Biology, 49, 2, 2014. Crossref

  14. Wright Rebecca L., Vaughan Andrew T.M., A systematic description of MLL fusion gene formation, Critical Reviews in Oncology/Hematology, 91, 3, 2014. Crossref

  15. Begum Nasim A., Nagaoka Hitoshi, Kobayashi Maki, Honjo Tasuku, Molecular Mechanisms of AID Function, in Molecular Biology of B Cells, 2015. Crossref

  16. Xu Zhenming, Fulop Zsolt, Wu Guikai, Pone Egest J, Zhang Jinsong, Mai Thach, Thomas Lisa M, Al-Qahtani Ahmed, White Clayton A, Park Seok-Rae, Steinacker Petra, Li Zenggang, Yates John, Herron Bruce, Otto Markus, Zan Hong, Fu Haian, Casali Paolo, 14-3-3 adaptor proteins recruit AID to 5′-AGCT-3′–rich switch regions for class switch recombination, Nature Structural & Molecular Biology, 17, 9, 2010. Crossref

  17. Heine Guido, Drozdenko Gennadiy, Grün Joachim R., Chang Hyun-Dong, Radbruch Andreas, Worm Margitta, Autocrine IL-10 promotes human B-cell differentiation into IgM- or IgG-secreting plasmablasts, European Journal of Immunology, 44, 6, 2014. Crossref

  18. Zan Hong, Zhang Jinsong, Al-Qahtani Ahmed, Pone Egest J., White Clayton A., Lee Derrik, Yel Leman, Mai Thach, Casali Paolo, Endonuclease G plays a role in immunoglobulin class switch DNA recombination by introducing double-strand breaks in switch regions, Molecular Immunology, 48, 4, 2011. Crossref

  19. Rakoff-Nahoum Seth, Medzhitov Ruslan, Toll-like receptors and cancer, Nature Reviews Cancer, 9, 1, 2009. Crossref

  20. Werner Markus, Hobeika Elias, Jumaa Hassan, Role of PI3K in the generation and survival of B cells, Immunological Reviews, 237, 1, 2010. Crossref

  21. Wright Rebecca L., Slemmons Katherine K., Vaughan Andrew T. M., Estradiol induces gene proximity andMLL–MLLT3fusion in an activation-induced cytidine deaminase-mediated pathway, Leukemia & Lymphoma, 56, 5, 2015. Crossref

  22. Brachs Sebastian, Turqueti-Neves Adriana, Stein Merle, Reimer Dorothea, Brachvogel Bent, Bösl Michael, Winkler Thomas, Voehringer David, Jäck Hans-Martin, Mielenz Dirk, Swiprosin-1/EFhd2 limits germinal center responses and humoral type 2 immunity, European Journal of Immunology, 44, 11, 2014. Crossref

  23. Xu Zhenming, Zan Hong, Pone Egest J., Mai Thach, Casali Paolo, Immunoglobulin class-switch DNA recombination: induction, targeting and beyond, Nature Reviews Immunology, 12, 7, 2012. Crossref

  24. Zan Hong, Casali Paolo, AID- and Ung-dependent generation of staggered double-strand DNA breaks in immunoglobulin class switch DNA recombination: A post-cleavage role for AID, Molecular Immunology, 46, 1, 2008. Crossref

  25. Pone Egest J., Zhang Jinsong, Mai Thach, White Clayton A., Li Guideng, Sakakura John K., Patel Pina J., Al-Qahtani Ahmed, Zan Hong, Xu Zhenming, Casali Paolo, BCR-signalling synergizes with TLR-signalling for induction of AID and immunoglobulin class-switching through the non-canonical NF-κB pathway, Nature Communications, 3, 1, 2012. Crossref

  26. Zaheen Ahmad, Martin Alberto, Activation-Induced Cytidine Deaminase and Aberrant Germinal Center Selection in the Development of Humoral Autoimmunities, The American Journal of Pathology, 178, 2, 2011. Crossref

  27. Ross A. Catharine, Chen Qiuyan, Ma Yifan, Augmentation of antibody responses by retinoic acid and costimulatory molecules, Seminars in Immunology, 21, 1, 2009. Crossref

  28. Potaczek D. P., Kabesch M., Current concepts of IgE regulation and impact of genetic determinants, Clinical & Experimental Allergy, 42, 6, 2012. Crossref

  29. Malavasi Fabio, Deaglio Silvia, Damle Rajendra, Cutrona Giovanna, Ferrarini Manlio, Chiorazzi Nicholas, CD38 and chronic lymphocytic leukemia: a decade later, Blood, 118, 13, 2011. Crossref

  30. Ha Yun Jung, Jeong Ji Hye, Park Yuna, Lee Jong Ran, Increased p190RhoGEF expression in activated B cells correlates with the induction of the plasma cell differentiation, Experimental & Molecular Medicine, 44, 2, 2012. Crossref

  31. Torgbor Charles, Awuah Peter, Deitsch Kirk, Kalantari Parisa, Duca Karen A., Thorley-Lawson David A., Munz Christian, A Multifactorial Role for P. falciparum Malaria in Endemic Burkitt's Lymphoma Pathogenesis, PLoS Pathogens, 10, 5, 2014. Crossref

  32. Mechtcheriakova Diana, Sobanov Yury, Holtappels Gabriele, Bajna Erika, Svoboda Martin, Jaritz Markus, Bachert Claus, Jensen-Jarolim Erika, Kassiotis George, Activation-Induced Cytidine Deaminase (AID)-Associated Multigene Signature to Assess Impact of AID in Etiology of Diseases with Inflammatory Component, PLoS ONE, 6, 10, 2011. Crossref

  33. Svoboda Martin, Meshcheryakova Anastasia, Heinze Georg, Jaritz Markus, Pils Dietmar, Castillo-Tong Dan Cacsire, Hager Gudrun, Thalhammer Theresia, Jensen-Jarolim Erika, Birner Peter, Braicu Ioana, Sehouli Jalid, Lambrechts Sandrina, Vergote Ignace, Mahner Sven, Zimmermann Philip, Zeillinger Robert, Mechtcheriakova Diana, AID/APOBEC-network reconstruction identifies pathways associated with survival in ovarian cancer, BMC Genomics, 17, 1, 2016. Crossref

  34. De Subhajyoti, Shaknovich Rita, Riester Markus, Elemento Olivier, Geng Huimin, Kormaksson Matthias, Jiang Yanwen, Woolcock Bruce, Johnson Nathalie, Polo Jose M., Cerchietti Leandro, Gascoyne Randy D., Melnick Ari, Michor Franziska, Grimes H. Leighton, Aberration in DNA Methylation in B-Cell Lymphomas Has a Complex Origin and Increases with Disease Severity, PLoS Genetics, 9, 1, 2013. Crossref

  35. White Clayton A., Seth Hawkins J., Pone Egest J., Yu Elliot S., Al-Qahtani Ahmed, Mai Thach, Zan Hong, Casali Paolo, AID dysregulation in lupus-prone MRL/Faslpr/lprmice increases class switch DNA recombination and promotes interchromosomalc-Myc/IgHloci translocations: Modulation by HoxC4, Autoimmunity, 44, 8, 2011. Crossref

  36. Wang Kuo, Gao Man, Yang Mingyue, Meng Fanzheng, Li Deli, Lu Ruihua, Wang Yan, Zhuang Huadong, Li Mengyao, Cheng Genhong, Wang Xiaosong, Transcriptome analysis of bronchoalveolar lavage fluid from children with severe Mycoplasma pneumoniae pneumonia reveals novel gene expression and immunodeficiency, Human Genomics, 11, 1, 2017. Crossref

  37. Chen Yingjia, Hu Fanlei, Dong Xuejiao, Zhao Meng, Wang Jing, Sun Xiaolin, Kim Tae Jin, Li Zhanguo, Liu Wanli, SHIP-1 Deficiency in AID+ B Cells Leads to the Impaired Function of B10 Cells with Spontaneous Autoimmunity, The Journal of Immunology, 199, 9, 2017. Crossref

  38. Nagata Keiko, Kumata Keisuke, Nakayama Yuji, Satoh Yukio, Sugihara Hirotsugu, Hara Sayuri, Matsushita Michiko, Kuwamoto Satoshi, Kato Masako, Murakami Ichiro, Hayashi Kazuhiko, Epstein–Barr Virus Lytic Reactivation Activates B Cells Polyclonally and Induces Activation-Induced Cytidine Deaminase Expression: A Mechanism Underlying Autoimmunity and Its Contribution to Graves' Disease, Viral Immunology, 30, 3, 2017. Crossref

  39. Choudhary Meenal, Tamrakar Anubhav, Singh Amit Kumar, Jain Monika, Jaiswal Ankit, Kodgire Prashant, AID Biology: A pathological and clinical perspective, International Reviews of Immunology, 37, 1, 2018. Crossref

  40. Nakayama Yumi, Kosek Jolanta, Capone Lori, Hur Eun Mi, Schafer Peter H., Ringheim Garth E., Aiolos Overexpression in Systemic Lupus Erythematosus B Cell Subtypes and BAFF-Induced Memory B Cell Differentiation Are Reduced by CC-220 Modulation of Cereblon Activity, The Journal of Immunology, 199, 7, 2017. Crossref

  41. Saghazadeh Amene, Rezaei Nima, Pulmonary Manifestations of Predominantly Antibody Deficiencies, in Pulmonary Manifestations of Primary Immunodeficiency Diseases, 2019. Crossref

  42. Chen Chuan, Wang Jie, Zhao Yun, Chen Shaopeng, Hu Zhishang, Chen Long, Hang Haiying, Enhancers Improve the AID-Induced Hypermutation in Episomal Vector for Antibody Affinity Maturation in Mammalian Cell Display, Antibodies, 7, 4, 2018. Crossref

  43. Park Chanho, Kim Tae Jin, Expansion and Sub-Classification of T Cell-Dependent Antibody Responses to Encompass the Role of Innate-Like T Cells in Antibody Responses, Immune Network, 18, 5, 2018. Crossref

  44. Nagata Keiko, Hara Sayuri, Nakayama Yuji, Higaki Katsumi, Sugihara Hirotsugu, Kuwamoto Satoshi, Matsushita Michiko, Kato Masako, Tanio Shunsuke, Ishiguro Kiyosuke, Hayashi Kazuhiko, Epstein–Barr Virus Lytic Reactivation Induces IgG4 Production by Host B Lymphocytes in Graves' Disease Patients and Controls: A Subset of Graves' Disease Is an IgG4-Related Disease-Like Condition, Viral Immunology, 31, 8, 2018. Crossref

  45. Haakenson Jeremy K., Huang Ruiqi, Smider Vaughn V., Diversity in the Cow Ultralong CDR H3 Antibody Repertoire, Frontiers in Immunology, 9, 2018. Crossref

  46. Roy Sumedha, Zhuang Yuan, Paradoxical role of Id proteins in regulating tumorigenic potential of lymphoid cells, Frontiers of Medicine, 12, 4, 2018. Crossref

  47. Lee Hyunjoo, Trott Joshua S., Haque Shabirul, McCormick Steven, Chiorazzi Nicholas, Mongini Patricia K. A., A Cyclooxygenase-2/Prostaglandin E2Pathway Augments Activation-Induced Cytosine Deaminase Expression within Replicating Human B Cells, The Journal of Immunology, 185, 9, 2010. Crossref

  48. Hua Yonglin, Zhang Jing, Jia Zhihao, Li Jian, Xiong Xianrong, Xiong Yan, Immune-related genes response to stimulation of miR-155 overexpression in CIK (ctenopharyngodon idella kidney) cells and zebrafish, Fish & Shellfish Immunology, 94, 2019. Crossref

  49. Indrevær Randi L., Moskaug Jan Ø., Paur Ingvild, Bøhn Siv K., Jørgensen Silje F., Blomhoff Rune, Aukrust Pål, Fevang Børre, Blomhoff Heidi K., IRF4 Is a Critical Gene in Retinoic Acid–Mediated Plasma Cell Formation and Is Deregulated in Common Variable Immunodeficiency–Derived B Cells, The Journal of Immunology, 195, 6, 2015. Crossref

  50. Varlet Emmanuel, Ovejero Sara, Martinez Anne-Marie, Cavalli Giacomo, Moreaux Jerome, Role of Polycomb Complexes in Normal and Malignant Plasma Cells, International Journal of Molecular Sciences, 21, 21, 2020. Crossref

  51. Nagata Keiko, Hayashi Kazuhiko, Epstein–Barr Virus Reactivation-Induced Immunoglobulin Production: Significance on Autoimmunity, Microorganisms, 8, 12, 2020. Crossref

  52. Eldin Patrick, Péron Sophie, Galashevskaya Anastasia, Denis-Lagache Nicolas, Cogné Michel, Slupphaug Geir, Briant Laurence, Impact of HIV-1 Vpr manipulation of the DNA repair enzyme UNG2 on B lymphocyte class switch recombination, Journal of Translational Medicine, 18, 1, 2020. Crossref

  53. Gaudette Brian T., Allman David, Biochemical coordination of plasma cell genesis, Immunological Reviews, 303, 1, 2021. Crossref

  54. Xu Jianqing, Ren Zhihong, Cao Kangli, Li Xianping, Yang Jing, Luo Xuelian, Zhu Lingyan, Wang Xiangwei, Ding Longfei, Liang Junrong, Jin Dong, Yuan Tingting, Li Lianfeng, Xu Jianguo, Boosting Vaccine-Elicited Respiratory Mucosal and Systemic COVID-19 Immunity in Mice With the Oral Lactobacillus plantarum, Frontiers in Nutrition, 8, 2021. Crossref

  55. Hutcheson Rebecca L., Chakravorty Adityarup, Sugden Bill, Burkitt Lymphomas Evolve to Escape Dependencies on Epstein-Barr Virus, Frontiers in Cellular and Infection Microbiology, 10, 2021. Crossref

  56. Petersen‐Mahrt Svend, Conticello Silvestro, Munagala Uday, Activation‐Induced Deaminase, in eLS, 2018. Crossref

  57. Li Guideng, Pone Egest J., Tran Daniel C., Patel Pina J., Dao Lisa, Xu Zhenming, Casali Paolo, Iron Inhibits Activation-induced Cytidine Deaminase Enzymatic Activity and Modulates Immunoglobulin Class Switch DNA Recombination, Journal of Biological Chemistry, 287, 25, 2012. Crossref

  58. Mai Thach, Zan Hong, Zhang Jinsong, Hawkins J. Seth, Xu Zhenming, Casali Paolo, Estrogen Receptors Bind to and Activate the HOXC4/HoxC4 Promoter to Potentiate HoxC4-mediated Activation-induced Cytosine Deaminase Induction, Immunoglobulin Class Switch DNA Recombination, and Somatic Hypermutation, Journal of Biological Chemistry, 285, 48, 2010. Crossref

  59. Lin Yu-Ling, Tsai Nu-Man, Hsieh Cheng-Hao, Ho Shu-Yi, Chang Jung, Wu Hsin-Yi, Hsu Ming-Hua, Chang Chia-Ching, Liao Kuang-Wen, Jackson Tiffany L. B., Mold David E., Huang Ru Chih C., In vivo amelioration of endogenous antitumor autoantibodies via low-dose P 4 N through the LTA4H/activin A/BAFF pathway , Proceedings of the National Academy of Sciences, 113, 48, 2016. Crossref

  60. Bouamar Hakim, Jiang Daifeng, Wang Long, Lin An-Ping, Ortega Manoela, Aguiar Ricardo C. T., MicroRNA 155 Control of p53 Activity Is Context Dependent and Mediated by Aicda and Socs1, Molecular and Cellular Biology, 35, 8, 2015. Crossref

  61. Boothby Mark R., Brookens Shawna K., Raybuck Ariel L., Cho Sung Hoon, Supplying the trip to antibody production—nutrients, signaling, and the programming of cellular metabolism in the mature B lineage, Cellular & Molecular Immunology, 19, 3, 2022. Crossref

  62. Sall Fatimata Bintou, El Amine Rawan, Markozashvili Diana, Tsfasman Tatyana, Oksenhendler Eric, Lipinski Marc, Vassetzky Yegor, Germini Diego, HIV‐1 Tat protein induces aberrant activation of AICDA in human B‐lymphocytes from peripheral blood , Journal of Cellular Physiology, 234, 9, 2019. Crossref

  63. Saborit-Villarroya I, Vaisitti T, Rossi D, D'Arena G, Gaidano G, Malavasi F, Deaglio S, E2A is a transcriptional regulator of CD38 expression in chronic lymphocytic leukemia, Leukemia, 25, 3, 2011. Crossref

  64. Hussain Shehnaz K., Zhu Weiming, Chang Shen-Chih, Breen Elizabeth Crabb, Vendrame Elena, Magpantay Larry, Widney Dan, Conn Daniel, Sehl Mary, Jacobson Lisa P., Bream Jay H., Wolinsky Steven, Rinaldo Charles R., Ambinder Richard F., Detels Roger, Zhang Zuo-Feng, Martínez-Maza Otoniel, Serum Levels of the Chemokine CXCL13, Genetic Variation in CXCL13 and Its Receptor CXCR5, and HIV-Associated Non-Hodgkin B-Cell Lymphoma Risk, Cancer Epidemiology, Biomarkers & Prevention, 22, 2, 2013. Crossref

  65. Lundberg Arian, Li Bailiang, Li Ruijiang, B cell-related gene signature and cancer immunotherapy response, British Journal of Cancer, 126, 6, 2022. Crossref

  66. Zhai Bing, Liu Xiaoling, Xu Yaqi, Zhu Gaizhi, Zhou Shan, He Youdi, Wang Xiaoqian, Su Wenting, Han Gencheng, Wang Renxi, Single-cell atlas of splenocytes reveals a critical role of a novel plasma cell‒specific marker Hspa13 in antibody class-switching recombination and somatic hypermutation, Molecular Immunology, 141, 2022. Crossref

  67. Park Seok-Rae, Kim Pyeung-Hyeun, Lee Kyu-Seon, Lee Sang-Hoon, Seo Goo-Young, Yoo Yung-Choon, Lee Junglim, Casali Paolo, APRIL stimulates NF-κB-mediated HoxC4 induction for AID expression in mouse B cells, Cytokine, 61, 2, 2013. Crossref

  68. Zhang Ping, Qin Mengting, Wang Yang, Chen Xiaodong, Miao Yinsha, Yuan Meng, Zhou Wen, Li Dandan, Wang Dan, Wang Mengying, Ai Li, Ma Yunfeng, Dong Yanying, Ji Yanhong, Inflammation accelerates BCR-ABL1+ B-ALL development through upregulation of AID, Blood Advances, 6, 13, 2022. Crossref

  69. Franiak-Pietryga Ida, Miyauchi Sayuri, Kim Sangwoo Shawn, Sanders Philip Dominick, Sumner Whitney, Zhang Lin, Mundt A.J., Califano Joseph A., Sharabi Andrew B., Activated B Cells and Plasma Cells Are Resistant to Radiation Therapy, International Journal of Radiation Oncology*Biology*Physics, 112, 2, 2022. Crossref

  70. Paranjape Amita M., Desai Sagar S., Nishana Mayilaadumveettil, Roy Urbi, Nilavar Namrata M., Mondal Amrita, Kumari Rupa, Radha Gudapureddy, Katapadi Vijeth Kumar, Choudhary Bibha, Raghavan Sathees C., Burma Sandeep, Nonamer dependent RAG cleavage at CpGs can explain mechanism of chromosomal translocations associated to lymphoid cancers, PLOS Genetics, 18, 10, 2022. Crossref

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