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Critical Reviews™ in Immunology
Импакт фактор: 1.352 5-летний Импакт фактор: 3.347 SJR: 0.657 SNIP: 0.55 CiteScore™: 2.19

ISSN Печать: 1040-8401
ISSN Онлайн: 2162-6472

Выпуски:
Том 39, 2019 Том 38, 2018 Том 37, 2017 Том 36, 2016 Том 35, 2015 Том 34, 2014 Том 33, 2013 Том 32, 2012 Том 31, 2011 Том 30, 2010 Том 29, 2009 Том 28, 2008 Том 27, 2007 Том 26, 2006 Том 25, 2005 Том 24, 2004 Том 23, 2003 Том 22, 2002 Том 21, 2001 Том 20, 2000 Том 19, 1999 Том 18, 1998 Том 17, 1997 Том 16, 1996 Том 15, 1995 Том 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v23.i56.60
16 pages

Compartmentalization g/d T Cells and Their Putative Role in Mucosal Immunity

Wolfgang Holtmeier
Medizinische Klinik II, Division of Gastroenterology, Johann Wolfgang Goethe-Universitat, 60590 Frankfurt am Main, Germany

Краткое описание

g/d T cells are an enigmatic group of cells and their functions still remain unknown. The epithelialassociated g/d T cells, which are abundant at mucosal surfaces, are ideally situated to contribute to the initial stages of the immune response. Recent evidence suggests that they recognize stress-induced self-antigens which would enable a homogenous population of g/d T cells to monitor multiple insults to the epithelium. This could explain the observed oligoclonality and homogenous distribution of cells carrying identical TCR within mucosal surfaces. However, the analysis of the TCR d repertoire from different mucosal surfaces indicated that g/d T cells are highly compartmentalized. Thus, g/d T cells are not one homogenous group of cells which recognize the same (stressinduced) self-antigens, but consist of different subsets that are likely to have distinct functions. It is possible that g/d T cells interact with antigens that are specific for that organ or recognize foreign antigens which are limited to that site. In addition it was shown that g/d T cells can have opposite functions and be proinflammatory or promote epithelial healing. This review focuses on the distribution and repertoire of mucosal g/d T cells and discusses what is currently known about the functions of these cells. Furthermore, their potential role in inflammatory bowel disease is examined.


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