Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Immunology
Импакт фактор: 1.352 5-летний Импакт фактор: 3.347 SJR: 0.657 SNIP: 0.55 CiteScore™: 2.19

ISSN Печать: 1040-8401
ISSN Онлайн: 2162-6472

Выпуски:
Том 39, 2019 Том 38, 2018 Том 37, 2017 Том 36, 2016 Том 35, 2015 Том 34, 2014 Том 33, 2013 Том 32, 2012 Том 31, 2011 Том 30, 2010 Том 29, 2009 Том 28, 2008 Том 27, 2007 Том 26, 2006 Том 25, 2005 Том 24, 2004 Том 23, 2003 Том 22, 2002 Том 21, 2001 Том 20, 2000 Том 19, 1999 Том 18, 1998 Том 17, 1997 Том 16, 1996 Том 15, 1995 Том 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.2019029559
pages 479-489

Biological and Clinical Significance of Human NKRP1A/LLT1 Receptor/Ligand Interactions

Agata Bialoszewska
Department of Histology and Embryology, Medical University of Warsaw, Warsaw, Poland
Jacek Malejczyk
Department of Histology and Embryology, Medical University of Warsaw, Warsaw, Poland

Краткое описание

Killer cell lectin-like receptors (KLRs) are C-type lectin-like glycoproteins encoded by genes clustered in the natural killer gene complex (NKC) located on the short arm of human chromosome 12. In addition to the NKG2 subfamily, the NKC includes a less characterized group of genes coding for NKRP1 receptors and their ligands of the C-type lectin (CLEC) subfamily. Among this group, the best recognized is the NKRP1A/LLT1 pair encoded respectively by the KLRB1 and CLEC2D genes. Both molecules are type II transmembrane-signaling glycoproteins with an extracellular C-type lectin domain. NKRP1A is predominantly expressed on NK cells, where it acts as an inhibitory receptor. However, it stimulates T cells, which results in release of IL-17 and inflammatory cytokines. Triggering LLT1 on NK cells stimulates IFN-γ production. Similarly, it stimulates activation of B cells. LLT1 is also expressed by osteoblasts and chondrocytes and inhibits bone degradation. Expression of LLT1 by tumor cells may facilitate their escape from NK cell surveillance. On the other hand, NKRP1A may be involved in activation of T and B lymphocytes in the course of inflammatory reactions and pathogenesis of autoimmune disorders. Thus, the NKRP1A/LLT1 receptor/ligand system appears to be a new therapeutic target that may be useful in the treatment of cancer as well as some autoinflammatory disorders.


Articles with similar content:

The Yin-Yang of KIR3DL1/S1: Molecular Mechanisms and Cellular Function
Critical Reviews™ in Immunology, Vol.33, 2013, issue 3
Geraldine M. O'Connor, Daniel W. McVicar
Genetically Engineered Natural Killer Cells as a Means for Adoptive Tumor Immunotherapy
Critical Reviews™ in Immunology, Vol.36, 2016, issue 4
Susanne Michen , Achim Temme
Interaction between the Human NK Receptors and Their Ligands
Critical Reviews™ in Immunology, Vol.20, 2000, issue 3
Mar Vales-Gomez, Hugh Reyburn, Jack L. Strominger
Role of SLAM Family Receptors and Specific Adapter SAP in Innate-Like Lymphocytes
Critical Reviews™ in Immunology, Vol.34, 2014, issue 4
Jordi Sintes, Xavier Romero, Pablo Engel
Inhibitory Receptor-Mediated Regulation of Natural Killer Cells
Critical Reviews™ in Immunology, Vol.34, 2014, issue 6
Beena Jeevan-Raj , Camille Grandclement, Werner Held, Elisenda Alari-Pahissa