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Critical Reviews™ in Immunology
Импакт фактор: 1.352 5-летний Импакт фактор: 3.347 SJR: 1.022 SNIP: 0.55 CiteScore™: 2.19

ISSN Печать: 1040-8401
ISSN Онлайн: 2162-6472

Выпуски:
Том 39, 2019 Том 38, 2018 Том 37, 2017 Том 36, 2016 Том 35, 2015 Том 34, 2014 Том 33, 2013 Том 32, 2012 Том 31, 2011 Том 30, 2010 Том 29, 2009 Том 28, 2008 Том 27, 2007 Том 26, 2006 Том 25, 2005 Том 24, 2004 Том 23, 2003 Том 22, 2002 Том 21, 2001 Том 20, 2000 Том 19, 1999 Том 18, 1998 Том 17, 1997 Том 16, 1996 Том 15, 1995 Том 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v15.i3-4.20
pages 215-233

Expression and Function of Fc Receptors in the Thymus

Georges Leclercq
Department of Clinical Chemistry, Microbiology and Immunology, University of Ghent, University Hospital, Blok A, De Pintelaan 185, B-9000 Ghent, Belgium
Jean Plum
Department of Clinical Chemistry, Microbiology and Immunology, University of Ghent, University Hospital, Blok A, De Pintelaan 185, B-9000 Ghent, Belgium

Краткое описание

In this review, the expression and function of Fc receptors (FcRs) in the thymus is discussed. In the murine thymus, FcγRII and FcγRIII are expressed on early thymocyte precursors, which can differentiate in both T and NK cells. TCR αβ thymocytes that are differentiating along the CD4-CD8 pathway do not express FcγRs any longer. Mature CD4-CD8 double negative TCR αβ and TCR Vγ3 cells, however, constitutively express FcγRII/III. The generation of gene-deficient mice has shown that neither FcγRs nor FcεRII are indispensable for murine thymus-dependent T cell development, whereas normal development of thymus-independent peripheral T cells is dependent on the presence of the FcRγ chain. In the human thymus, a low number of CD3-CD4-CD8 triple negative cells expresses FcγRIII, but these cells are mainly NK cells. FcεRII is expressed on human thymic epithelial cells. Although the unaltered thymic development of T cells in FcR-deficient mice argues against a fundamental role of FcRs in this process, recent demonstration of FcR ligands of non-immunoglobulin nature in the thymus indicates that the interaction between FcRs and their ligands in the thymus might influence T cell development.

Ключевые слова: CD 16, CD23, CD32, γ, chain, ζ, chain, deficient mice

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