Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Immunology
Импакт фактор: 1.352 5-летний Импакт фактор: 3.347 SJR: 0.657 SNIP: 0.55 CiteScore™: 2.19

ISSN Печать: 1040-8401
ISSN Онлайн: 2162-6472

Выпуски:
Том 39, 2019 Том 38, 2018 Том 37, 2017 Том 36, 2016 Том 35, 2015 Том 34, 2014 Том 33, 2013 Том 32, 2012 Том 31, 2011 Том 30, 2010 Том 29, 2009 Том 28, 2008 Том 27, 2007 Том 26, 2006 Том 25, 2005 Том 24, 2004 Том 23, 2003 Том 22, 2002 Том 21, 2001 Том 20, 2000 Том 19, 1999 Том 18, 1998 Том 17, 1997 Том 16, 1996 Том 15, 1995 Том 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v15.i1.20
pages 31-75

Evolution and Developmental Regulation of the Major Histocompatibility Complex

Luisa Salter-Cid
Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL 33101
Martin F. Flajnik
Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL 33101

Краткое описание

The ontogeny and evolution of the major histocompatibility complex (MHC) are blossoming fields that grant insight into the origins of the adaptive immune system and into the strategies adopted by particular groups of vertebrates for expression of MHC during development. This review surveys general topics concerning MHC evolution, with special emphasis on the significance of linkage of gene families within the MHC; a model is proposed in which the MHC class III region is the "primordial immune complex" with its members giving rise to classical MHC molecules. The developmental expression of MHC, both of the classical and non-classical genes, is described in detail with a concentration on differential expression by extraembryonic tissues in mammals and by tissues in "transition" during metamorphosis in amphibians.


Articles with similar content:

Function of Histone Deacetylase Inhibitors in Inflammation
Critical Reviews™ in Immunology, Vol.31, 2011, issue 3
Paul P. Tak, Kris A. Reedquist, Aleksander M. Grabiec
Interrelationships between Nuclear Structure and Ligand-Activated Intracellular Receptors
Critical Reviews™ in Eukaryotic Gene Expression, Vol.6, 1996, issue 2-3
Thomas S. Ruh, Mary F. Ruh, Robert Dunn, II
Gene Regulation Associated with Apoptosis
Critical Reviews™ in Eukaryotic Gene Expression, Vol.7, 1997, issue 1-2
Barbara A. Osborne, Birgit M. Jehn
Deacetylation of Chromatin and Gene Expression Regulation: A New Target for Epigenetic Therapy
Critical Reviews™ in Oncogenesis, Vol.20, 2015, issue 1-2
Heidi Olzscha, Nicholas B. La Thangue, Semira Sheikh
Regulation of RUNX1 Transcriptional Function by GATA-1
Critical Reviews™ in Eukaryotic Gene Expression, Vol.17, 2007, issue 4
Kamaleldin E. Elagib, Adam N. Goldfarb