Выходит 6 номеров в год
ISSN Печать: 1040-8401
ISSN Онлайн: 2162-6472
IF:
1.3
5-Year IF:
2.6
Eigenfactor:
0.00079
JCI:
0.24
SJR:
0.429
SNIP:
0.287
CiteScore™::
2.7
H-Index:
81
Indexed in
Rapid Clearance of Bacteria and Their Toxins: Development of Therapeutic Proteins
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Краткое описание
The emergence of pathogens and toxins with resistance against conventional drugs, vaccines, and host defense peptides and proteins warrants novel countermeasures that can efficiently capture and rapidly clear them. This article examines the utility of chimeric proteins with capture and clearance domains as a novel countermeasure against pathogens and their toxins. The capture and clearance domains are chosen from the large repertoire of host defense peptides and proteins. Although individual capture and clearance domains are rendered ineffective by pathogenic resistance mechanisms, chimeric scaffolds can be designed to retain their antimicrobial activity, even in the face of pathogenic resistance. Here, initial studies on the design of chimeric proteins targeted against (1) intact bacteria such as Xylella fastidiosa (plant pathogens), Salmonella spp. (food-borne pathogens), and Staphylococcus aureus (blood-borne pathogens); and (2) lethal toxins from Bacillus anthracis are described.
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Ibáñez Ana, Agüero Cecilia, Escobar Mathew, Dandekar Abhaya, Transgenic Fruit and Nut Tree Crops Review, in Transgenic Horticultural Crops, 2011. Crossref
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Rendón-Ramírez Adela, Shukla Manish, Oda Masataka, Chakraborty Sandeep, Minda Renu, Dandekar Abhaya M., Ásgeirsson Bjarni, Goñi Félix M., Rao Basuthkar J., Uversky Vladimir N., A Computational Module Assembled from Different Protease Family Motifs Identifies PI PLC from Bacillus cereus as a Putative Prolyl Peptidase with a Serine Protease Scaffold, PLoS ONE, 8, 8, 2013. Crossref
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Chakraborty Sandeep, Uversky Vladimir N., An Automated Flow for Directed Evolution Based on Detection of Promiscuous Scaffolds Using Spatial and Electrostatic Properties of Catalytic Residues, PLoS ONE, 7, 7, 2012. Crossref
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Dandekar Abhaya M., Gouran Hossein, Ibáñez Ana María, Uratsu Sandra L., Agüero Cecilia B., McFarland Sarah, Borhani Yasmin, Feldstein Paul A., Bruening George, Nascimento Rafael, Goulart Luiz R., Pardington Paige E., Chaudhary Anu, Norvell Meghan, Civerolo Edwin, Gupta Goutam, An engineered innate immune defense protects grapevines from Pierce disease, Proceedings of the National Academy of Sciences, 109, 10, 2012. Crossref
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Basu Supratim, Sineva Elena, Nguyen Liza, Sikdar Narattam, Park Jong Won, Sinev Mikhail, Kunta Madhurababu, Gupta Goutam, Host-derived chimeric peptides clear the causative bacteria and augment host innate immunity during infection: A case study of HLB in citrus and fire blight in apple, Frontiers in Plant Science, 13, 2022. Crossref