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Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Immunology
Импакт фактор: 1.352 5-летний Импакт фактор: 3.347 SJR: 1.022 SNIP: 0.55 CiteScore™: 2.19

ISSN Печать: 1040-8401
ISSN Онлайн: 2162-6472

Выпуски:
Том 39, 2019 Том 38, 2018 Том 37, 2017 Том 36, 2016 Том 35, 2015 Том 34, 2014 Том 33, 2013 Том 32, 2012 Том 31, 2011 Том 30, 2010 Том 29, 2009 Том 28, 2008 Том 27, 2007 Том 26, 2006 Том 25, 2005 Том 24, 2004 Том 23, 2003 Том 22, 2002 Том 21, 2001 Том 20, 2000 Том 19, 1999 Том 18, 1998 Том 17, 1997 Том 16, 1996 Том 15, 1995 Том 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v27.i3.40
pages 233-245

Rapid Clearance of Bacteria and Their Toxins: Development of Therapeutic Proteins

Meghan Kunkel
Biosciences Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
Momchilo Vuyisich
Biosciences Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
Gnana Gnanakaran
Theory Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
George E. Bruening
Plant Pathology, UC Davis, Davis, CA 95616, USA
Abhaya M. Dandekar
Plant Sciences, UC Davis, Davis, CA 95616, USA
Edwin Civerolo
San Joaquin Valley Agricultural Sciences Center, USDA-ARS, Parlier, Parlier, CA 93648, USA
John J. Marchalonis
Department of Immunobiology, University of Arizona College of Medicine P.O. Box 24-5049 Tucson, AZ 85724
Goutam Gupta
Biosciences Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA

Краткое описание

The emergence of pathogens and toxins with resistance against conventional drugs, vaccines, and host defense peptides and proteins warrants novel countermeasures that can efficiently capture and rapidly clear them. This article examines the utility of chimeric proteins with capture and clearance domains as a novel countermeasure against pathogens and their toxins. The capture and clearance domains are chosen from the large repertoire of host defense peptides and proteins. Although individual capture and clearance domains are rendered ineffective by pathogenic resistance mechanisms, chimeric scaffolds can be designed to retain their antimicrobial activity, even in the face of pathogenic resistance. Here, initial studies on the design of chimeric proteins targeted against (1) intact bacteria such as Xylella fastidiosa (plant pathogens), Salmonella spp. (food-borne pathogens), and Staphylococcus aureus (blood-borne pathogens); and (2) lethal toxins from Bacillus anthracis are described.


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